Object-Centered Neglect in Patients with Unilateral Neglect: Effects of Left-Right Coordinates of Objects

When patients with right-sided hemispheric lesions neglect information on the left side, with respect to what set of spatial coordinates is left defined? Two potential reference frames were examined in this study, one where left and right are defined with respect to the midline of the viewer and/or environment (viewer/env-centered) and the other where left and right are defined with respect to the midline of the object (object-centered). By rotating the stimulus 90 clockwise or counterclockwise, and instructing patients with neglect to report the colors appearing around the border of a stimulus, an independent measure was obtained for the number of colors reported from the left and right of the viewer/env- and from the object-based reference frame. Whereas significant object-centered neglect was observed only for upper case asymmetrical letters but not for symmetrical letters nor for drawings of familiar animals or objects, significant viewer/env-based neglect was observed with all the stimulus types. We present an account of the coexistence of neglect in more than one frame of reference and the presence of object-centered neglect under a restricted set of conditions.

[1]  E. Bisiach,et al.  Mental Representation in Unilateral Neglect and Related Disorders: The Twentieth Bartlett Memorial Lecture , 1993, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[2]  M. Tarr,et al.  Mental rotation and orientation-dependence in shape recognition , 1989, Cognitive Psychology.

[3]  A Donabedian,et al.  A frame of reference. , 1976, QRB. Quality review bulletin.

[4]  E. Làdavas,et al.  Is the hemispatial deficit produced by right parietal lobe damage associated with retinal or gravitational coordinates? , 1987, Brain : a journal of neurology.

[5]  On the First Ground of the Distinction of Regions in Space , 1991 .

[6]  Leslie G. Ungerleider.  Two cortical visual systems , 1982 .

[7]  Ian Robertson,et al.  Early rightwards orienting of attention on simple reaction time performance in patients with left-sided neglect , 1992, Neuropsychologia.

[8]  G. Humphreys.  Reference frames and shape perception , 1983, Cognitive Psychology.

[9]  Alfonso Caramazza,et al.  Deficit to stimulus-centered, letter shape representations in a case of “unilateral neglect” , 1991, Neuropsychologia.

[10]  J. Mattingley,et al.  Selective attention in humans: normality and pathology , 1995, Current Opinion in Neurobiology.

[11]  J. Stein.  The representation of egocentric space in the posterior parietal cortex. , 1992, The Behavioral and brain sciences.

[12]  Geoffrey E. Hinton.  A Parallel Computation that Assigns Canonical Object-Based Frames of Reference , 1981, IJCAI.

[13]  S. Tipper,et al.  Object-based and environment-based inhibition of return of visual attention. , 1994 .

[14]  Jon Driver,et al.  Preserved figure-ground segregation and symmetry perception in visual neglect , 1992, Nature.

[15]  J. G. Snodgrass,et al.  A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. , 1980, Journal of experimental psychology. Human learning and memory.

[16]  P. Carpenter,et al.  Frames of reference for allocating attention to space: Evidence from the neglect syndrome , 1990, Neuropsychologia.

[17]  M. Mozer,et al.  On the Interaction of Selective Attention and Lexical Knowledge: A Connectionist Account of Neglect Dyslexia , 1990, Journal of Cognitive Neuroscience.

[18]  David E. Meyer,et al.  Interactions between Object and Space Systems Revealed through Neuropsychology , 1993 .

[19]  Marcia Grabowecky,et al.  Preattentive Processes Guide Visual Search: Evidence from Patients with Unilateral Visual Neglect , 1993, Journal of Cognitive Neuroscience.

[20]  M. Kinsbourne.  Mechanisms of Unilateral Neglect , 1987 .

[21]  David C. Plaut,et al.  Visual Object Representation: Interpreting Neurophysiological Data within a Computational Framework , 1990, Journal of Cognitive Neuroscience.

[22]  Martha Flanders,et al.  Psychophysical approaches to motor control , 1995, Current Opinion in Neurobiology.

[23]  M. Corballis.  Recognition of disoriented shapes. , 1988, Psychological review.

[24]  S. Tipper,et al.  Short Report: Object-Centred Inhibition of Return of Visual Attention , 1991, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[25]  M. Mesulam.  A cortical network for directed attention and unilateral neglect , 1981, Annals of neurology.

[26]  J. Driver,et al.  Can Visual Neglect Operate in Object-centred Co-ordinates? An Affirmative Single-case Study , 1991 .

[27]  D. Levine,et al.  Left visual spatial neglect is both environment‐centered and body‐centered , 1987, Neurology.

[28]  D. Marr,et al.  Representation and recognition of the spatial organization of three-dimensional shapes , 1978, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[29]  Morris Moscovitch,et al.  Coding of Spatial Information in the Somatosensory System: Evidence from Patients with Neglect following Parietal Lobe Damage , 1994, Journal of Cognitive Neuroscience.

[30]  J. Feldman.  Four frames suffice: A provisional model of vision and space , 1985, Behavioral and Brain Sciences.

[31]  E. Bisiach,et al.  Disorders of perceived auditory lateralization after lesions of the right hemisphere. , 1984, Brain : a journal of neurology.

[32]  G. Rizzolatti,et al.  Neglect as a neural representation deficit. , 1990, Revue neurologique.

[33]  E. Renzi,et al.  The Occurrence of Visual Neglect in Patients With Unilateral Cerebral Disease , 1976, Cortex.

[34]  N. Kanwisher,et al.  Objects, Attributes, and Visual Attention: Which, What, and Where , 1992 .

[35]  H. Karnath,et al.  Trunk orientation as the determining factor of the 'contralateral' deficit in the neglect syndrome and as the physical anchor of the internal representation of body orientation in space. , 1991, Brain : a journal of neurology.

[36]  Lynn C. Robertson,et al.  Visual Search Performance in the Neglect Syndrome , 1989, Journal of Cognitive Neuroscience.

[37]  P. Jolicoeur.  The time to name disoriented natural objects , 1985, Memory & cognition.

[38]  D. Perani,et al.  The anatomy of unilateral neglect after right-hemisphere stroke lesions. A clinical/CT-scan correlation study in man , 1986, Neuropsychologia.

[39]  Jenni A Ogden,et al.  Anterior-posterior interhemispheric differences in the loci of lesions producing visual hemineglect , 1985, Brain and Cognition.

[40]  Robin Walker,et al.  Spatial and object-based neglect , 1995 .

[41]  M. Mozer,et al.  Perceptual and Conceptual Mechanisms in Neglect Dyslexia: Two Contrasting Case Studies , 1990 .

[42]  A. Greenwald.  LEVELS OF REPRESENTATION , 1988 .

[43]  Carlo Umiltà,et al.  The Deployment of Visual Attention in the Intact Field of Hemineglect Patients , 1990, Cortex.

[44]  M. Tarr,et al.  When does Human Object Recognition use a Viewer-Centered Reference Frame? , 1990 .

[45]  Cheryl L. Grady,et al.  Functional Associations among Human Posterior Extrastriate Brain Regions during Object and Spatial Vision , 1992, Journal of Cognitive Neuroscience.

[46]  Jon Driver,et al.  Object segmentation and visual neglect , 1995, Behavioural Brain Research.

[47]  H. Karnath,et al.  Decrease of contralateral neglect by neck muscle vibration and spatial orientation of trunk midline. , 1993, Brain : a journal of neurology.

[48]  M. Gazzaniga,et al.  Disturbances in Spatial Attention Following Lesion or Disconnection of the Right Parietal Lobe , 1987 .

[49]  G. Pellegrino,et al.  Coordinate Frames for Naming Misoriented Chimerics: A Case Study of Visuo-Spatial Neglect , 1995, Cortex.

[50]  P. Jolicoeur,et al.  The spatial frame of reference in object naming and discrimination of left-right reflections , 1990, Memory & cognition.

[51]  Alfonso Caramazza,et al.  A framework for interpreting distinct patterns of hemispatial neglect , 1995 .

[52]  Leslie G. Ungerleider,et al.  Object vision and spatial vision: two cortical pathways , 1983, Trends in Neurosciences.

[53]  A. Young,et al.  Neglect and visual recognition. , 1992, Brain : a journal of neurology.

[54]  M. Farah,et al.  Viewer-Centered and Object-Centered Representations in the Recognition of Naturalistic Line Drawings , 1991 .

[55]  F. V. Eynde.  The levels of representation , 1986 .

[56]  Alfonso Caramazza,et al.  Levels of representation, co-ordinate frames, and unilateral neglect , 1990 .

[57]  E. Bisiach,et al.  Unilateral Neglect of Representational Space , 1978, Cortex.