APPLICATION OF EMPIRICAL MODE DECOMPOSITION–BASED FEATURES FOR ANALYSIS OF NORMAL AND CAD HEART RATE SIGNALS

Coronary Artery Disease (CAD) is a heart disease caused due to insufficient supply of nutrients and oxygen to the heart muscles. Hence, reduced supply of nutrients and oxygen causes heart attack or stroke and may cause death. Also significant number of people are suffering from CAD around the world so timely diagnosis of CAD can save the life of patients. In this work, we have proposed computer assisted diagnosis of CAD using Heart Rate (HR) signals obtained from Electrocardiogram (ECG) signals. We have used the Empirical Mode Decomposition (EMD) technique to process the HR signals. The features namely: Second-Order Difference Plot (SODP) area, Analytic Signal Representation (ASR) area, Amplitude Modulation (AM) bandwidth, Frequency Modulation (FM) bandwidth and Fourier–Bessel expansion (FBE)- based mean frequency computed from the Intrinsic Mode Functions (IMFs) are extracted to discriminate normal and CAD subjects. Thereafter, Kruskal–Wallis statistical test is performed on these features. The features having p-value less than 0.05 are considered to be significant. Our results show that three features namely: AM bandwidth, FM bandwidth and FBE-based mean frequency are more suitable than ASR area and SODP area features for discrimination of normal and CAD subjects.

[1]  J. Schroeder Signal Processing via Fourier-Bessel Series Expansion , 1993 .

[2]  Kostas Karamanos,et al.  Block Entropy Analysis of Heart Rate Variability Signals , 2006, Int. J. Bifurc. Chaos.

[3]  Pradip Sircar,et al.  Analysis of multicomponent AM-FM signals using FB-DESA method , 2010, Digit. Signal Process..

[4]  Yvonne Tran,et al.  Analysis of eyes open, eye closed EEG signals using second-order difference plot , 2007, Medical & Biological Engineering & Computing.

[5]  Rajeev Sharma,et al.  Classification of Normal and Epileptic Seizure EEG Signals Based on Empirical Mode Decomposition , 2015, Complex System Modelling and Control Through Intelligent Soft Computations.

[6]  Pooja Jain,et al.  Event-Based Method for Instantaneous Fundamental Frequency Estimation from Voiced Speech Based on Eigenvalue Decomposition of the Hankel Matrix , 2014, IEEE/ACM Transactions on Audio, Speech, and Language Processing.

[7]  Willis J. Tompkins,et al.  A Real-Time QRS Detection Algorithm , 1985, IEEE Transactions on Biomedical Engineering.

[8]  Ram Bilas Pachori,et al.  Empirical Mode Decomposition-Based Detection of Bend-Induced Error and Its Correction in a Raman Optical Fiber Distributed Temperature Sensor , 2016, IEEE Sensors Journal.

[9]  Kaliappan Gopalan,et al.  A comparison of speaker identification results using features based on cepstrum and Fourier-Bessel expansion , 1999, IEEE Trans. Speech Audio Process..

[10]  Pradip Sircar,et al.  EEG signal analysis using FB expansion and second-order linear TVAR process , 2008, Signal Process..

[11]  Nathan D. Wong,et al.  Epidemiological studies of CHD and the evolution of preventive cardiology , 2014, Nature Reviews Cardiology.

[12]  U. Rajendra Acharya,et al.  Linear and nonlinear analysis of normal and CAD-affected heart rate signals , 2014, Comput. Methods Programs Biomed..

[13]  T.E. Prieto,et al.  Measures of postural steadiness: differences between healthy young and elderly adults , 1996, IEEE Transactions on Biomedical Engineering.

[14]  C. M. Lim,et al.  Cardiac state diagnosis using higher order spectra of heart rate variability , 2008, Journal of medical engineering & technology.

[15]  J. Fleiss,et al.  RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction. , 1995, Circulation.

[16]  U. Rajendra Acharya,et al.  Automated diagnosis of coronary artery disease using tunable-Q wavelet transform applied on heart rate signals , 2015, Knowl. Based Syst..

[17]  Ram Bilas Pachori,et al.  Classification of Seizure and Nonseizure EEG Signals Using Empirical Mode Decomposition , 2012, IEEE Transactions on Information Technology in Biomedicine.

[18]  N. Huang,et al.  The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis , 1998, Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[19]  Pradip Sircar,et al.  A new technique to reduce cross terms in the Wigner distribution , 2007, Digit. Signal Process..

[20]  R. Warlar,et al.  Integer coefficient bandpass filter for the simultaneous removal of baseline wander, 50 and 100 Hz interference from the ECG , 1991, Medical and Biological Engineering and Computing.

[21]  H. Huikuri,et al.  Circadian Rhythms of Frequency Domain Measures of Heart Rate Variabilit in Healthy Subjects and Patients With Coronary Artery Disease: Effects of Arousal and Upright Posture , 1994, Circulation.

[22]  C. M. Lim,et al.  Analysis of cardiac health using fractal dimension and wavelet transformation , 2005 .

[23]  Ram Bilas Pachori,et al.  Analysis of normal and epileptic seizure EEG signals using empirical mode decomposition , 2011, Comput. Methods Programs Biomed..

[24]  Oguz Findik,et al.  A comparison of feature selection models utilizing binary particle swarm optimization and genetic algorithm in determining coronary artery disease using support vector machine , 2010, Expert Syst. Appl..

[25]  David J. Hewson,et al.  Univariate and Bivariate Empirical Mode Decomposition for Postural Stability Analysis , 2008, EURASIP J. Adv. Signal Process..

[26]  U. Rajendra Acharya,et al.  Application of empirical mode decomposition for analysis of normal and diabetic RR-interval signals , 2015, Expert Syst. Appl..

[27]  Nong Ye,et al.  Recent Developments in Chaotic Time Series Analysis , 2003, Int. J. Bifurc. Chaos.

[28]  Ram Bilas Pachori,et al.  Epileptic seizure classification in EEG signals using second-order difference plot of intrinsic mode functions , 2014, Comput. Methods Programs Biomed..

[29]  Manuchehr Soleimani,et al.  Medical imaging and physiological modelling: linking physics and biology , 2009, Biomedical engineering online.

[30]  U. Rajendra Acharya,et al.  Automated diagnosis of Coronary Artery Disease affected patients using LDA, PCA, ICA and Discrete Wavelet Transform , 2013, Knowl. Based Syst..

[31]  Pradip Sircar,et al.  Parametric representation of speech employing multi-component AFM signal model , 2015, Int. J. Speech Technol..

[32]  R. Acharya U,et al.  Comprehensive analysis of cardiac health using heart rate signals , 2004, Physiological measurement.

[33]  Ram Bilas Pachori,et al.  Discrimination between Ictal and Seizure-Free EEG Signals Using Empirical Mode Decomposition , 2008, J. Electr. Comput. Eng..

[34]  Keun Ho Ryu,et al.  Mining Biosignal Data: Coronary Artery Disease Diagnosis Using Linear and Nonlinear Features of HRV , 2007, PAKDD Workshops.