Fatigue and pruritus at onset identify a more aggressive subset of primary biliary cirrhosis

In recent years, primary biliary cirrhosis is mostly diagnosed in patients who are asymptomatic; however, a proportion of cases still present with typical complaints such as fatigue and/or pruritus. We compared biochemical, histological and immunological features of patients with or without fatigue and/or pruritus at onset to see whether the different clinical presentation may eventually impact on disease progression.

[1]  Y. Maehara,et al.  Genetic polymorphisms of OCT-1 confer susceptibility to severe progression of primary biliary cirrhosis in Japanese patients , 2014, Journal of Gastroenterology.

[2]  A. Burroughs,et al.  The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort. , 2013, Journal of hepatology.

[3]  C. Levy,et al.  Primary biliary cirrhosis: therapeutic advances. , 2013, Clinics in liver disease.

[4]  G. Alexander,et al.  Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid. , 2013, Gastroenterology.

[5]  K. Siminovitch,et al.  Pathway-based analysis of primary biliary cirrhosis genome-wide association studies , 2013, Genes and Immunity.

[6]  P. Gregersen,et al.  Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. , 2012, Human molecular genetics.

[7]  A. Granito,et al.  Antinuclear antibodies as ancillary markers in primary biliary cirrhosis , 2012, Expert review of molecular diagnostics.

[8]  P. Invernizzi.  Human leukocyte antigen in primary biliary cirrhosis: An old story now reviving , 2011, Hepatology.

[9]  R. Coppel,et al.  Primary biliary cirrhosis , 2011, The Lancet.

[10]  T. Arenovich,et al.  Baseline Ductopenia and Treatment Response Predict Long-Term Histological Progression in Primary Biliary Cirrhosis , 2010, The American Journal of Gastroenterology.

[11]  Fabio Macciardi,et al.  Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis , 2010, Nature Genetics.

[12]  R. Poupon.  Primary biliary cirrhosis: a 2010 update. , 2010, Journal of hepatology.

[13]  A. Granito,et al.  Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis , 2009, Autoimmunity.

[14]  F. Lammert,et al.  EASL Clinical Practice Guidelines: management of cholestatic liver diseases. , 2009, Journal of hepatology.

[15]  M. Seldin,et al.  Human leukocyte antigen polymorphisms in italian primary biliary cirrhosis: A multicenter study of 664 patients and 1992 healthy controls , 2008, Hepatology.

[16]  Y. Chrétien,et al.  Biochemical response to ursodeoxycholic acid and long‐term prognosis in primary biliary cirrhosis , 2008, Hepatology.

[17]  A. Granito,et al.  Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value. , 2008, Clinics in liver disease.

[18]  R. Chapman,et al.  Antinuclear antibodies giving the ‘multiple nuclear dots’ or the ‘rim‐like/membranous’ patterns: diagnostic accuracy for primary biliary cirrhosis , 2006, Alimentary pharmacology & therapeutics.

[19]  J. Rodés,et al.  Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic Acid. , 2006, Gastroenterology.

[20]  A. Czaja,et al.  ‘True’ antimitochondrial antibody‐negative primary biliary cirrhosis, low sensitivity of the routine assays, or both? , 2004, Clinical and experimental immunology.

[21]  G. Bianchi,et al.  Characterization and Clinical Impact of Antinuclear Antibodies in Primary Biliary Cirrhosis , 2003, American Journal of Gastroenterology.

[22]  O. Chazouilleres,et al.  Primary biliary cirrhosis–autoimmune hepatitis overlap syndrome: Clinical features and response to therapy , 1998, Hepatology.

[23]  K. Lindor,et al.  Primary biliary cirrhosis , 1998, Springer Netherlands.