Familial L723P mutation can shift the distribution between the alternative APP transmembrane domain cleavage cascades by local unfolding of the ε-cleavage site suggesting a straightforward mechanism of Alzheimer's disease pathogenesis.
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O. Bocharova | A. Arseniev | R. Efremov | P. Volynsky | K. Pavlov | E. Bocharov | A. Urban | K. Nadezhdin