Cancer and Noncancer Mortality in Populations Living Near Uranium and Vanadium Mining and Milling Operations in Montrose County, Colorado, 1950–2000

Abstract Boice, J. D., Jr., Mumma, M. T. and Blot, W. J. Cancer and Noncancer Mortality in Populations Living Near Uranium and Vanadium Mining and Milling Operations in Montrose County, Colorado, 1950–2000. Radiat. Res. 167, 711–726 (2007). Mining and milling of uranium in Montrose County on the Western Slope of Colorado began in the early 1900s and continued until the early 1980s. To evaluate the possible impact of these activities on the health of communities living on the Colorado Plateau, mortality rates between 1950 and 2000 among Montrose County residents were compared to rates among residents in five similar counties in Colorado. Standardized mortality ratios (SMRs) were computed as the ratio of observed numbers of deaths in Montrose County to the expected numbers of deaths based on mortality rates in the general populations of Colorado and the United States. Relative risks (RRs) were computed as the ratio of the SMRs for Montrose County to the SMRs for the five comparison counties. Between 1950 and 2000, a total of 1,877 cancer deaths occurred in the population residing in Montrose County, compared with 1,903 expected based on general population rates for Colorado (SMRCO 0.99). There were 11,837 cancer deaths in the five comparison counties during the same 51-year period compared with 12,135 expected (SMRCO 0.98). There was no difference between the total cancer mortality rates in Montrose County and those in the comparison counties (RR = 1.01; 95% CI 0.96–1.06). Except for lung cancer among males (RR = 1.19; 95% CI 1.06–1.33), no statistically significant excesses were seen for any causes of death of a priori interest: cancers of the breast, kidney, liver, bone, or childhood cancer, leukemia, non-Hodgkin lymphoma, renal disease or nonmalignant respiratory disease. Lung cancer among females was decreased (RR = 0.83; 95% CI 0.67–1.02). The absence of elevated mortality rates of cancer in Montrose County over a period of 51 years suggests that the historical milling and mining operations did not adversely affect the health of Montrose County residents. Although descriptive correlation analyses such as this preclude definitive causal inferences, the increased lung cancer mortality seen among males but not females is most likely due to prior occupational exposure to radon and cigarette smoking among underground miners residing in Montrose County, consistent with previous cohort studies of Colorado miners and of residents of the town of Uravan in Montrose County.

[1]  J. Boice,et al.  Cancer in populations living near nuclear facilities. A survey of mortality nationwide and incidence in two states. , 1991, JAMA.

[2]  A. Auvinen,et al.  Kidney toxicity of ingested uranium from drinking water. , 2006, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[3]  M. Möhner,et al.  Leukemia and exposure to ionizing radiation among German uranium miners. , 2006, American journal of industrial medicine.

[4]  William L. Bigbee,et al.  Cancer Incidence in Municipalities near Two Former Nuclear Materials Processing Facilities in Pennsylvania—An Update , 2009, Health physics.

[5]  J. Ingle,et al.  External radiation exposure and mortality in a cohort of uranium processing workers. , 2000, American journal of epidemiology.

[6]  V. E. Archer,et al.  Radon daughter exposure and respiratory cancer quantitative and temporal aspects , 1971 .

[7]  N. Priest.  Toxicity of depleted uranium , 2001, The Lancet.

[8]  S. Darby,et al.  Radon and cancers other than lung cancer in underground miners: a collaborative analysis of 11 studies. , 1995, Journal of the National Cancer Institute.

[9]  William J Blot,et al.  CANCER INCIDENCE IN MUNICIPALITIES NEAR TWO FORMER NUCLEAR MATERIALS PROCESSING FACILITIES IN PENNSYLVANIA , 2003, Health physics.

[10]  A. Auvinen,et al.  Renal effects of uranium in drinking water. , 2002, Environmental health perspectives.

[11]  Icrp.  Age-dependent doses to members of the public from intake of radionuclides: Part 4 Inhalation dose coefficients , 1995, Annals of the ICRP.

[12]  A. Auvinen,et al.  Bone as a Possible Target of Chemical Toxicity of Natural Uranium in Drinking Water , 2004, Environmental health perspectives.

[13]  D. Laurier,et al.  RADON EXPOSURE AND THE RISK OF LEUKEMIA: A REVIEW OF EPIDEMIOLOGICAL STUDIES , 2001, Health physics.

[14]  E. Feuer,et al.  SEER Cancer Statistics Review, 1975-2003, National Cancer Institute. Bethesda, MD, , 2006 .

[15]  A. Auvinen,et al.  Uranium and other natural radionuclides in drinking water and risk of leukemia: a case–cohort study in Finland , 2002, Cancer Causes & Control.

[16]  R. Doll,et al.  Residential radon and lung cancer--detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiologic studies in Europe. , 2006, Scandinavian journal of work, environment & health.

[17]  A. Auvinen,et al.  Well water radioactivity and risk of cancers of the urinary organs. , 2006, Environmental research.

[18]  C. Kuepper.  Dietary reference intakes , 2000 .

[19]  P. Rössner,et al.  Monitoring genotoxic exposure in uranium mines. , 1993, Environmental health perspectives.

[20]  Division on Earth.  Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2 , 2006 .

[21]  S. E. Dietert,et al.  A histological kidney study of uranium and non-uranium workers. , 1996, Health physics.

[22]  J. Fraumeni,et al.  Uranium mill tailings and cancer mortality in Colorado. , 1972, Journal of the National Cancer Institute.

[23]  L. Pinkerton,et al.  Mortality among a cohort of uranium mill workers: an update. , 2004, Occupational and environmental medicine.

[24]  S. Darby,et al.  Radon exposure and cancers other than lung cancer among uranium miners in West Bohemia , 1993, The Lancet.

[25]  R. Stone,et al.  OCMAP-PLUS: a program for the comprehensive analysis of occupational cohort data. , 1998, Journal of occupational and environmental medicine.

[26]  R. Hoover,et al.  Lung cancer after employment in shipyards during World War II. , 1978, The New England journal of medicine.

[27]  William J Blot,et al.  CANCER MORTALITY IN COUNTIES NEAR TWO FORMER NUCLEAR MATERIALS PROCESSING FACILITIES IN PENNSYLVANIA, 1950–1995 , 2003, Health physics.

[28]  Uk Childhood Cancer Study Investigators,et al.  The United Kingdom Childhood Cancer Study of exposure to domestic sources of ionising radiation: 1: radon gas , 2002, British Journal of Cancer.

[29]  G. Beebe,et al.  Thyroid nodularity and chromosome aberrations among women in areas of high background radiation in China. , 1990, Journal of the National Cancer Institute.

[30]  M. Thun,et al.  Individual- and area-level socioeconomic status variables as predictors of mortality in a cohort of 179,383 persons. , 2004, American journal of epidemiology.

[31]  C. Poole.  Ecologic analysis as outlook and method. , 1994, American journal of public health.

[32]  J. Haseman,et al.  Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[33]  I. Kawachi,et al.  Race/Ethnic and Nativity Disparities in Child Overweight in the United States and England , 2012, The Annals of the American Academy of Political and Social Science.

[34]  B. Golomb,et al.  A Review of the Scientific Literature as it Pertains to Gulf War Illnesses , 1998 .

[35]  L. Stayner,et al.  Mortality among a cohort of garment workers exposed to formaldehyde: an update , 2004, Occupational and Environmental Medicine.

[36]  S. Wacholder,et al.  Case-control study of childhood acute lymphoblastic leukemia and residential radon exposure. , 1998, Journal of the National Cancer Institute.

[37]  J. Boice,et al.  Cancer mortality in a Texas county with prior uranium mining and milling activities, 1950-2001. , 2003, Journal of radiological protection : official journal of the Society for Radiological Protection.

[38]  R. Roscoe.  An update of mortality from all causes among white uranium miners from the Colorado Plateau Study Group. , 1997, American journal of industrial medicine.

[39]  S. Fry.  Studies of U.S. radium dial workers: an epidemiological classic. , 1998, Radiation research.

[40]  A S Whittemore,et al.  Lung cancer mortality among U.S. uranium miners: a reappraisal. , 1983, Journal of the National Cancer Institute.

[41]  Kyle Steenland,et al.  All-cause and cause-specific death rates by educational status for two million people in two American Cancer Society cohorts, 1959-1996. , 2002, American journal of epidemiology.

[42]  R. Sram,et al.  Monitoring genotoxic exposure in uranium miners. , 1993, Environmental health perspectives.

[43]  D. Sandler,et al.  Incidence of Leukemia, Lymphoma, and Multiple Myeloma in Czech Uranium Miners: A Case–Cohort Study , 2006, Environmental health perspectives.

[44]  J. Neuberger,et al.  Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. , 1997, Journal of the National Cancer Institute.

[45]  C. M. West,et al.  Uranium Dust Exposure and Lung Cancer Risk in Four Uranium Processing Operations , 1995, Epidemiology.

[46]  A. Auvinen,et al.  Radon and other natural radionuclides in drinking water and risk of stomach cancer: A case‐cohort study in Finland , 2005, International journal of cancer.

[47]  R. Kathren.  The Health Hazards of Depleted Uranium Munitions Part I , 2001 .

[48]  John C. Bailar,et al.  202. Note: Significance Factors for the Ratio of a Poisson Variable to Its Expectation , 1964 .

[49]  D. Taylor,et al.  Environmental Uranium and Human Health , 1997, Reviews on environmental health.

[50]  Uk Childhood Cancer Study Investigators,et al.  The United Kingdom Childhood Cancer Study of exposure to domestic sources of ionising radiation: 2: gamma radiation , 2002, British Journal of Cancer.