Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease.

[1]  Cuong Nguyen,et al.  Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging. , 2016, Journal of pharmacological and toxicological methods.

[2]  Jeong-Woo Choi,et al.  Phototactic guidance of a tissue-engineered soft-robotic ray , 2016, Science.

[3]  Xuetao Sun,et al.  Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes. , 2016, Methods.

[4]  I. Domian,et al.  Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation. , 2016, Cell reports.

[5]  Candan Tamerler,et al.  Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells. , 2016, ACS applied materials & interfaces.

[6]  Gordana Vunjak-Novakovic,et al.  Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes , 2016, Nature Communications.

[7]  Robert W. Mills,et al.  Bioengineering Human Myocardium on Native Extracellular Matrix. , 2016, Circulation research.

[8]  Eduardo Kausel,et al.  Integrated Analysis of Contractile Kinetics, Force Generation, and Electrical Activity in Single Human Stem Cell-Derived Cardiomyocytes , 2015, Stem cell reports.

[9]  Neil J. Daily,et al.  Improving Cardiac Action Potential Measurements: 2D and 3D Cell Culture. , 2015, Journal of bioengineering & biomedical science.

[10]  C. Ward,et al.  Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle , 2015, Nature Communications.

[11]  C. Hong,et al.  Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes. , 2015, Biomaterials.

[12]  Deepak Srivastava,et al.  Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness , 2015, Proceedings of the National Academy of Sciences.

[13]  Lior Gepstein,et al.  Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters , 2015, Stem cell reports.

[14]  Eva Wagner,et al.  Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. , 2015, Biomaterials.

[15]  Gordon Keller,et al.  Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell‐Derived Progenitors , 2015, Stem cells.

[16]  Sean P. Palecek,et al.  Chemically defined, albumin-free human cardiomyocyte generation , 2015, Nature Methods.

[17]  Robert Passier,et al.  Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology. , 2015, Biomaterials.

[18]  Nancy K. Drew,et al.  Metrics for Assessing Cytoskeletal Orientational Correlations and Consistency , 2015, PLoS Comput. Biol..

[19]  Kevin Kit Parker,et al.  Structural Phenotyping of Stem Cell-Derived Cardiomyocytes , 2015, Stem cell reports.

[20]  M. Radisic,et al.  Design and formulation of functional pluripotent stem cell-derived cardiac microtissues (vol 110, pg E4698, 2013) , 2014 .

[21]  K. Kolaja,et al.  Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. , 2014, Cell reports.

[22]  I. Domian,et al.  Molecular Etching: A Novel Methodology for the Generation of Complex Micropatterned Growth Surfaces for Human Cellular Assays , 2014, Advanced healthcare materials.

[23]  Teruo Okano,et al.  Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration , 2014, Scientific Reports.

[24]  K. Pekkan,et al.  Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects , 2014, Front. Physiol..

[25]  P. Burridge,et al.  Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system , 2014, Science Translational Medicine.

[26]  M. Kyba,et al.  Acquisition of a Quantitative, Stoichiometrically Conserved Ratiometric Marker of Maturation Status in Stem Cell-Derived Cardiac Myocytes , 2014, Stem cell reports.

[27]  K. Red-Horse,et al.  Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as an In Vitro Model for Coxsackievirus B3–Induced Myocarditis and Antiviral Drug Screening Platform , 2014, Circulation research.

[28]  S. Kattman,et al.  The generation of the epicardial lineage from human pluripotent stem cells , 2014, Nature Biotechnology.

[29]  Anthony Atala,et al.  3D bioprinting of tissues and organs , 2014, Nature Biotechnology.

[30]  Kevin Kit Parker,et al.  Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. , 2014, Biomaterials.

[31]  G. Whitesides,et al.  Three‐Dimensional Paper‐Based Model for Cardiac Ischemia , 2014, Advanced healthcare materials.

[32]  Praveen Shukla,et al.  Chemically defined generation of human cardiomyocytes , 2014, Nature Methods.

[33]  Deok‐Ho Kim,et al.  Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink , 2014, Nature Communications.

[34]  Megan L. McCain,et al.  Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. , 2014, American journal of physiology. Heart and circulatory physiology.

[35]  George A. Truskey,et al.  Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies , 2014, Nature Medicine.

[36]  Sangyoon J. Han,et al.  Measuring the contractile forces of human induced pluripotent stem cell-derived cardiomyocytes with arrays of microposts. , 2014, Journal of biomechanical engineering.

[37]  K. Shakesheff,et al.  Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation , 2014, Proceedings of the National Academy of Sciences.

[38]  F. Villarreal,et al.  Dynamic Changes in Myocardial Matrix and Relevance to Disease: Translational Perspectives , 2014, Circulation research.

[39]  Robert W. Mills,et al.  Rapid Cellular Phenotyping of Human Pluripotent Stem Cell-Derived Cardiomyocytes using a Genetically Encoded Fluorescent Voltage Sensor , 2014, Stem cell reports.

[40]  Sean P. Palecek,et al.  Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes. , 2014, Acta biomaterialia.

[41]  Christopher S. Chen,et al.  Necking and failure of constrained 3D microtissues induced by cellular tension , 2013, Proceedings of the National Academy of Sciences.

[42]  Kumaraswamy Nanthakumar,et al.  Design and formulation of functional pluripotent stem cell-derived cardiac microtissues , 2013, Proceedings of the National Academy of Sciences.

[43]  P. Doevendans,et al.  Wnt/β-catenin signaling directs the regional expansion of first and second heart field-derived ventricular cardiomyocytes , 2013, Development.

[44]  Nenad Bursac,et al.  Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. , 2013, Biomaterials.

[45]  A. Boulesteix,et al.  What is the “normal” fetal heart rate? , 2013, PeerJ.

[46]  Donald M Bers,et al.  Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity , 2013, Circulation.

[47]  I. Domian,et al.  Generation of aligned functional myocardial tissue through microcontact printing. , 2013, Journal of visualized experiments : JoVE.

[48]  C. Murray,et al.  Temporal Trends in Ischemic Heart Disease Mortality in 21 World Regions, 1980 to 2010: The Global Burden of Disease 2010 Study , 2013, Circulation.

[49]  A. Darzi,et al.  The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells , 2013, Biomaterials.

[50]  Deborah K. Lieu,et al.  Mechanism-Based Facilitated Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes , 2013, Circulation. Arrhythmia and electrophysiology.

[51]  Erik Willems,et al.  Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery , 2013, Circulation research.

[52]  Vincent L. Butty,et al.  Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment , 2013, Cell.

[53]  Carlos Torroja,et al.  Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy , 2013, Nature Medicine.

[54]  Euan A Ashley,et al.  Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. , 2013, Cell stem cell.

[55]  Ernst J. Wolvetang,et al.  Microbioreactor Arrays for Full Factorial Screening of Exogenous and Paracrine Factors in Human Embryonic Stem Cell Differentiation , 2012, PloS one.

[56]  H. Calkins,et al.  Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs , 2012, Nature.

[57]  Yvonne Will,et al.  Characterization of human-induced pluripotent stem cell-derived cardiomyocytes: bioenergetics and utilization in safety screening. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[58]  Richard T. Lee,et al.  Mammalian Heart Renewal by Preexisting Cardiomyocytes , 2012, Nature.

[59]  Alexander R. Pico,et al.  Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage , 2012, Cell.

[60]  Jürgen Hescheler,et al.  Human Pluripotent Stem Cell-Derived Cardiomyocytes: Response to TTX and Lidocain Reveals Strong Cell to Cell Variability , 2012, PloS one.

[61]  Sean P Sheehy,et al.  Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. , 2012, Biomaterials.

[62]  Christine L Mummery,et al.  Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview. , 2012, Circulation research.

[63]  C. Mummery,et al.  Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease , 2012, Circulation.

[64]  Sean P. Palecek,et al.  Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling , 2012, Proceedings of the National Academy of Sciences.

[65]  J. Jalife,et al.  Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues , 2012, Circulation research.

[66]  Thomas Boudou,et al.  A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. , 2012, Tissue engineering. Part A.

[67]  R. Passier,et al.  NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes , 2011, Nature Methods.

[68]  Ronald A. Li,et al.  Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes , 2011, PloS one.

[69]  W. Zimmermann,et al.  The Cardiogenic Niche as a Fundamental Building Block of Engineered Myocardium , 2011, Cells Tissues Organs.

[70]  Tal Dvir,et al.  Nanowired three dimensional cardiac patches , 2011, Nature nanotechnology.

[71]  Masayuki Yamato,et al.  Stacking of aligned cell sheets for layer-by-layer control of complex tissue structure. , 2011, Biomaterials.

[72]  Yanjie Lu,et al.  Difference of Sodium Currents between Pediatric and Adult Human Atrial Myocytes: Evidence for Developmental Changes of Sodium Channels , 2011, International journal of biological sciences.

[73]  Milica Radisic,et al.  Biphasic electrical field stimulation aids in tissue engineering of multicell-type cardiac organoids. , 2011, Tissue engineering. Part A.

[74]  Xuan Yuan,et al.  A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability , 2011, PloS one.

[75]  Jing Zhang,et al.  Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals , 2011, Cell Research.

[76]  G. Keller,et al.  Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. , 2011, Cell stem cell.

[77]  R. Dolmetsch,et al.  Using iPS cells to investigate cardiac phenotypes in patients with Timothy Syndrome , 2011, Nature.

[78]  Munir Pirmohamed,et al.  Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology , 2011, European journal of heart failure.

[79]  Valerie M. Weaver,et al.  The extracellular matrix at a glance , 2010, Journal of Cell Science.

[80]  H. Smeets,et al.  Electrical signals affect the cardiomyocyte transcriptome independently of contraction. , 2010, Physiological genomics.

[81]  Wei-Zhong Zhu,et al.  Neuregulin/ErbB Signaling Regulates Cardiac Subtype Specification in Differentiating Human Embryonic Stem Cells , 2010, Circulation research.

[82]  V. Regitz-Zagrosek,et al.  Differential Cardiac Remodeling in Preload Versus Afterload , 2010, Circulation.

[83]  Dennis E Discher,et al.  How deeply cells feel: methods for thin gels , 2010, Journal of physics. Condensed matter : an Institute of Physics journal.

[84]  G. Lajoie,et al.  Matrigel: A complex protein mixture required for optimal growth of cell culture , 2010, Proteomics.

[85]  Sean P Sheehy,et al.  Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. , 2010, Biomaterials.

[86]  Milica Radisic,et al.  Influence of substrate stiffness on the phenotype of heart cells , 2010, Biotechnology and bioengineering.

[87]  Milica Radisic,et al.  Challenges in cardiac tissue engineering. , 2010, Tissue engineering. Part B, Reviews.

[88]  Andre Levchenko,et al.  Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs , 2009, Proceedings of the National Academy of Sciences.

[89]  K. Healy,et al.  Characterization of Matrigel interfaces during defined human embryonic stem cell culture , 2009, Biointerphases.

[90]  Richard O. Hynes,et al.  The Extracellular Matrix: Not Just Pretty Fibrils , 2009, Science.

[91]  Kevin Kit Parker,et al.  Generation of Functional Ventricular Heart Muscle from Mouse Ventricular Progenitor Cells , 2009, Science.

[92]  D. Roberts,et al.  Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages , 2009, Nature.

[93]  B. Clarkson,et al.  Fibronectin adsorption studied using neutron reflectometry and complementary techniques , 2009, The European physical journal. E, Soft matter.

[94]  Christopher S. Chen,et al.  Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues , 2009, Proceedings of the National Academy of Sciences.

[95]  D. E. Discher,et al.  Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis , 2009 .

[96]  Justin S. Weinbaum,et al.  Cell-induced alignment augments twitch force in fibrin gel-based engineered myocardium via gap junction modification. , 2009, Tissue engineering. Part A.

[97]  Sean P. Palecek,et al.  Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells , 2009, Circulation research.

[98]  Adam J Engler,et al.  Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating , 2008, Journal of Cell Science.

[99]  Samuel Bernard,et al.  Evidence for Cardiomyocyte Renewal in Humans , 2008, Science.

[100]  Ronald A. Li,et al.  Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state. , 2008, Biochemical and biophysical research communications.

[101]  Eric D. Adler,et al.  Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population , 2008, Nature.

[102]  K. Klose,et al.  B-type natriuretic peptide and wall stress in dilated human heart , 2008, Molecular and Cellular Biochemistry.

[103]  Doris A Taylor,et al.  Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart , 2008, Nature Medicine.

[104]  Milica Radisic,et al.  Interactive effects of surface topography and pulsatile electrical field stimulation on orientation and elongation of fibroblasts and cardiomyocytes. , 2007, Biomaterials.

[105]  G. Whitesides,et al.  Muscular Thin Films for Building Actuators and Powering Devices , 2007, Science.

[106]  Lila R Collins,et al.  Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts , 2007, Nature Biotechnology.

[107]  E. Bettiol,et al.  Developmental Changes in Cardiomyocytes Differentiated from Human Embryonic Stem Cells: A Molecular and Electrophysiological Approach , 2007, Stem cells.

[108]  Wolfgang A Linke,et al.  Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction. , 2007, Cardiovascular research.

[109]  P. Burridge,et al.  Improved Human Embryonic Stem Cell Embryoid Body Homogeneity and Cardiomyocyte Differentiation from a Novel V‐96 Plate Aggregation System Highlights Interline Variability , 2007, Stem cells.

[110]  D. Clapham,et al.  In Brief , 2006, Nature Reviews Drug Discovery.

[111]  Wolfram-Hubertus Zimmermann,et al.  Optimizing Engineered Heart Tissue for Therapeutic Applications as Surrogate Heart Muscle , 2006, Circulation.

[112]  Andreas Hess,et al.  Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts , 2006, Nature Medicine.

[113]  Robert Passier,et al.  Increased Cardiomyocyte Differentiation from Human Embryonic Stem Cells in Serum‐Free Cultures , 2005, Stem cells.

[114]  H. Kleinman,et al.  Complex Extracellular Matrices Promote Tissue‐Specific Stem Cell Differentiation , 2005, Stem cells.

[115]  Milica Radisic,et al.  Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[116]  M C Leake,et al.  Passive Stiffness Changes Caused by Upregulation of Compliant Titin Isoforms in Human Dilated Cardiomyopathy Hearts , 2004, Circulation research.

[117]  Milica Radisic,et al.  Medium perfusion enables engineering of compact and contractile cardiac tissue. , 2004, American journal of physiology. Heart and circulatory physiology.

[118]  Rene Spijker,et al.  Differentiation of Human Embryonic Stem Cells to Cardiomyocytes: Role of Coculture With Visceral Endoderm-Like Cells , 2003, Circulation.

[119]  Thomas Brand,et al.  Heart development: molecular insights into cardiac specification and early morphogenesis. , 2003, Developmental biology.

[120]  G. Fishman,et al.  The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions , 2003, Journal of Cell Science.

[121]  L Gepstein,et al.  Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. , 2001, The Journal of clinical investigation.

[122]  Thomas Eschenhagen,et al.  Three‐dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[123]  J E Saffitz,et al.  Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. , 1994, Circulation research.

[124]  J. Sanger,et al.  Costameres are sites of force transmission to the substratum in adult rat cardiomyocytes , 1992, The Journal of cell biology.

[125]  S. Colan,et al.  Developmental modulation of myocardial mechanics: age- and growth-related alterations in afterload and contractility. , 1992, Journal of the American College of Cardiology.

[126]  L Tung,et al.  Influence of electrical axis of stimulation on excitation of cardiac muscle cells. , 1991, Circulation research.

[127]  S. Seifter,et al.  Morphology, composition, and function of struts between cardiac myocytes of rat and hamster , 1987, Cell and Tissue Research.

[128]  W Grossman,et al.  Wall stress and patterns of hypertrophy in the human left ventricle. , 1975, The Journal of clinical investigation.

[129]  Sebastian A. Leidel,et al.  Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs. , 2016, Cell stem cell.

[130]  Xiaohong Wang,et al.  Pathologic function and therapeutic potential of exosomes in cardiovascular disease. , 2015, Biochimica et biophysica acta.

[131]  I. Georgakoudi,et al.  Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro. , 2014, Acta biomaterialia.

[132]  遠山 周吾.  Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes , 2013 .

[133]  E. Sasaki,et al.  Nongenetic method for purifying stem cell–derived cardiomyocytes , 2010, Nature Methods.

[134]  K. Pritchett-Corning.  Euthanasia of neonatal rats with carbon dioxide. , 2009, Journal of the American Association for Laboratory Animal Science : JAALAS.

[135]  K. Pritchett-Corning,et al.  Euthanasia of neonatal rats with carbon dioxide. , 2009, Journal of the American Association for Laboratory Animal Science : JAALAS.

[136]  D. Seliktar,et al.  Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial. , 2007, Acta biomaterialia.

[137]  Downloaded from http://circres.ahajournals.org / by guest on February 21, 2013Restoration of Resting Sarcomere Length After Uniaxial Static Strain Is Regulated by Protein Kinase C � and Focal , 2022 .