Prefrontal gray matter volume reduction in first episode schizophrenia.

Functional measures have consistently shown prefrontal abnormalities in schizophrenia. However, structural magnetic resonance imaging (MRI) findings of prefrontal volume reduction have been less consistent. In this study, we evaluated prefrontal gray matter volume in first episode (first hospitalized) patients diagnosed with schizophrenia, compared with first episode patients diagnosed with affective psychosis and normal comparison subjects, to determine the presence in and specificity of prefrontal abnormalities to schizophrenia. Prefrontal gray and white matter volumes were measured from first episode patients with schizophrenia (n = 17), and from gender and parental socio-economic status-matched subjects with affective (mainly manic) psychosis (n = 17) and normal comparison subjects (n = 17), age-matched within a narrow age range (18--29 years). Total (left and right) prefrontal gray matter volume was significantly reduced in first episode schizophrenia compared with first episode affective psychosis and comparison subjects. Follow-up analyses indicated significant left prefrontal gray matter volume reduction and trend level reduction on the right. Schizophrenia patients showed 9.2% reduction on the left and 7.7% reduction on the right compared with comparison subjects. White matter volumes did not differ among groups. These data suggest that prefrontal cortical gray matter volume reduction is selectively present at first hospitalization in schizophrenia but not affective psychosis.

[1]  Cynthia G. Wible,et al.  Parcellation of the human prefrontal cortex using MRI , 1997, Psychiatry Research: Neuroimaging.

[2]  R. McCarley,et al.  MRI anatomy of schizophrenia , 1999, Biological Psychiatry.

[3]  R. McCarley,et al.  Large CSF volume not attributable to ventricular volume in schizotypal personality disorder. , 2000, The American journal of psychiatry.

[4]  P. Goldman-Rakic,et al.  Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three‐dimensional, stereologic counting method , 1998, The Journal of comparative neurology.

[5]  K O Lim,et al.  A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. , 1998, Archives of general psychiatry.

[6]  J. Ehrhardt,et al.  Brain morphology in first-episode schizophrenia. , 1995, The American journal of psychiatry.

[7]  J. Fleiss,et al.  The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. , 1976, Archives of general psychiatry.

[8]  S. Rauch,et al.  Neuroimaging and Neurobiological Models of Depression , 1997, Harvard review of psychiatry.

[9]  S. Lewallen,et al.  Role for traditional healers in eye care , 1995, The Lancet.

[10]  P. Mazzoni,et al.  Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. , 1998, The American journal of psychiatry.

[11]  Sohee Park,et al.  Schizophrenics show spatial working memory deficits. , 1992, Archives of general psychiatry.

[12]  D. Mathalon,et al.  A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. , 1994, Archives of neurology.

[13]  N J Yasillo,et al.  Abnormal-pursuit eye movements in schizophrenia. Evidence for a genetic indicator. , 1977, Archives of general psychiatry.

[14]  R. Knight,et al.  Prefrontal cortex regulates inhibition and excitation in distributed neural networks. , 1999, Acta psychologica.

[15]  E. Miller,et al.  The Prefrontal Cortex Complex Neural Properties for Complex Behavior , 1999, Neuron.

[16]  R. Kikinis,et al.  3D Morphometric and Morphologic Information Derived From Clinical Brain MR Images , 1990 .

[17]  W. Eric L. Grimson,et al.  Adaptive Segmentation of MRI Data , 1995, CVRMed.

[18]  R. C. Oldfield The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[19]  D J Mikulis,et al.  Cerebral gray matter volume deficits in first episode psychosis. , 1998, Archives of general psychiatry.

[20]  B. Turetsky,et al.  Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia. , 2000, Archives of general psychiatry.

[21]  R. Langevin,et al.  Deficits in gray matter volume are present in schizophrenia but not bipolar disorder 1 This work was presented at the Meeting of the Society of Biological Psychiatry, Philadelphia, PA, USA, May 1994. 1 , 1997, Schizophrenia Research.

[22]  W T Carpenter,et al.  Structural abnormalities in deficit and nondeficit schizophrenia. , 1993, The American journal of psychiatry.

[23]  Manzar Ashtari,et al.  Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine , 1995, The Lancet.

[24]  August B. Hollingshead,et al.  Two Factor Index of Social Position , 1957 .

[25]  R Kikinis,et al.  Prefrontal cortex and schizophrenia. A quantitative magnetic resonance imaging study. , 1995, Archives of general psychiatry.

[26]  J. Overall,et al.  The Brief Psychiatric Rating Scale , 1962 .

[27]  Godfrey D Pearlson,et al.  Structural brain imaging in schizophrenia: a selective review , 1999, Biological Psychiatry.

[28]  G. Pearlson,et al.  Structural evaluation of the prefrontal cortex in schizophrenia. , 1998, The American journal of psychiatry.

[29]  R. Murray,et al.  Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls , 1994, Psychological Medicine.

[30]  R. Kikinis,et al.  Subgenual cingulate cortex volume in first-episode psychosis. , 1999, The American journal of psychiatry.

[31]  P. Goldman-Rakic,et al.  The reduced neuropil hypothesis: a circuit based model of schizophrenia , 1999, Biological Psychiatry.

[32]  Tyrone D. Cannon,et al.  A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. , 1998, Archives of general psychiatry.

[33]  K O Lim,et al.  A profile of cortical gray matter volume deficits characteristic of schizophrenia. , 1998, Cerebral cortex.

[34]  P. Goldman-Rakic,et al.  Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure , 1999, Biological Psychiatry.

[35]  G. Pearlson,et al.  Decreased regional cortical gray matter volume in schizophrenia. , 1994, The American journal of psychiatry.

[36]  D. Weinberger,et al.  Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. , 1986, Archives of general psychiatry.

[37]  P. C. Murphy,et al.  Cerebral Cortex , 2017, Cerebral Cortex.