Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

[1]  Nathan D. Kingery,et al.  Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes , 2016, The Journal of Neuroscience.

[2]  J. Rogers,et al.  Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function , 2016, PloS one.

[3]  A. Verkhratsky,et al.  Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment , 2016, Glia.

[4]  E. Chang,et al.  Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse , 2016, Neuron.

[5]  D. Lauffenburger,et al.  Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening , 2015, Scientific Reports.

[6]  A. Verkhratsky,et al.  Glial Asthenia and Functional Paralysis , 2015, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[7]  Min Jung Park,et al.  Abstract T MP20: Histone Methylation Patterns in Astrocytes are Influenced by Age Following Ischemia , 2015, Stroke.

[8]  E. Hol,et al.  Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction , 2014, Neurobiology of Aging.

[9]  A. Lavi,et al.  DOC2B and Munc13-1 differentially regulate neuronal network activity. , 2014, Cerebral cortex.

[10]  Qingli Xiao,et al.  Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis , 2014, The Journal of Neuroscience.

[11]  Emily K. Lehrman,et al.  An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. , 2014, Journal of visualized experiments : JoVE.

[12]  G. Ingram,et al.  Complement activation in multiple sclerosis plaques: an immunohistochemical analysis , 2014, Acta Neuropathologica Communications.

[13]  S. Mandel,et al.  DJ‐1 deficiency triggers microglia sensitivity to dopamine toward a pro‐inflammatory phenotype that is attenuated by rasagiline , 2014, Journal of neurochemistry.

[14]  E. Hol,et al.  Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice , 2014, Neurobiology of Aging.

[15]  E. Huang,et al.  A Dramatic Increase of C1q Protein in the CNS during Normal Aging , 2013, The Journal of Neuroscience.

[16]  Nathan D. Kingery,et al.  Scara1 deficiency impairs clearance of soluble Amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression , 2013, Nature Communications.

[17]  D. Frenkel,et al.  Scavenger Receptor A Deficiency Accelerates Cerebrovascular Amyloidosis in an Animal Model , 2013, Journal of Molecular Neuroscience.

[18]  Andrew W. Kraft,et al.  Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  E. Syková,et al.  Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer’s disease , 2012, Journal of anatomy.

[20]  Peyman Golshani,et al.  Associative Fear Learning Enhances Sparse Network Coding in Primary Sensory Cortex , 2012, Neuron.

[21]  Ben A. Barres,et al.  Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner , 2012, Neuron.

[22]  B. Barres,et al.  Genomic Analysis of Reactive Astrogliosis , 2012, The Journal of Neuroscience.

[23]  F. Helmchen,et al.  In vivo labeling of cortical astrocytes with sulforhodamine 101 (SR101). , 2012, Cold Spring Harbor protocols.

[24]  M. Blankenstein,et al.  The effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes , 2012, Experimental Neurology.

[25]  Mark H. Ellisman,et al.  Development of a Method for the Purification and Culture of Rodent Astrocytes , 2011, Neuron.

[26]  D. Peterson,et al.  Phenotypic and gene expression modification with normal brain aging in GFAP‐positive astrocytes and neural stem cells , 2011, Aging cell.

[27]  J. Rothstein,et al.  Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice , 2011, Glia.

[28]  D. Farfara,et al.  γ‐Secretase component presenilin is important for microglia β‐amyloid clearance , 2011, Annals of neurology.

[29]  J. Morris,et al.  Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease , 2010, Science.

[30]  D. Attwell,et al.  Glial and neuronal control of brain blood flow , 2022 .

[31]  R. Veerhuis,et al.  Astrocytic Aβ1‐42 uptake is determined by Aβ‐aggregation state and the presence of amyloid‐associated proteins , 2010, Glia.

[32]  A. Verkhratsky,et al.  Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease , 2011, ASN neuro.

[33]  A. Verkhratsky,et al.  Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease , 2010, Glia.

[34]  A. Tenner,et al.  C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production , 2010, Journal of neurochemistry.

[35]  M. Sofroniew,et al.  Astrocytes: biology and pathology , 2009, Acta Neuropathologica.

[36]  M. Sofroniew Molecular dissection of reactive astrogliosis and glial scar formation , 2009, Trends in Neurosciences.

[37]  F. Heppner,et al.  Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia , 2009, Nature Neuroscience.

[38]  R. Veerhuis,et al.  Binding and uptake of Aβ1‐42 by primary human astrocytes in vitro , 2009, Glia.

[39]  G. Halliday,et al.  Monocyte Chemoattractant Protein‐1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease , 2009, Brain pathology.

[40]  Y. Xing,et al.  A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function , 2008, The Journal of Neuroscience.

[41]  K. Ravichandran,et al.  Engulfment of apoptotic cells: signals for a good meal , 2007, Nature Reviews Immunology.

[42]  P. Magistretti,et al.  Activity‐dependent regulation of energy metabolism by astrocytes: An update , 2007, Glia.

[43]  J. Rothstein,et al.  Variations in Promoter Activity Reveal a Differential Expression and Physiology of Glutamate Transporters by Glia in the Developing and Mature CNS , 2007, The Journal of Neuroscience.

[44]  F. L. D. Silva,et al.  Complement activation in experimental and human temporal lobe epilepsy , 2007, Neurobiology of Disease.

[45]  J. Rothstein,et al.  Mechanisms of Disease: astrocytes in neurodegenerative disease , 2006, Nature Clinical Practice Neurology.

[46]  M. Ohno,et al.  Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation , 2006, The Journal of Neuroscience.

[47]  David M Holtzman,et al.  Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo , 2006, Nature Medicine.

[48]  R. Malenka,et al.  Synaptic scaling mediated by glial TNF-α , 2006, Nature.

[49]  Soojin Lee,et al.  TLR3‐mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: Differential signaling mechanisms of TLR3‐induced IP‐10 and IL‐8 gene expression , 2006, Glia.

[50]  R. von Bernhardi,et al.  Expression of Scavenger Receptors in Glial Cells , 2005, Journal of Biological Chemistry.

[51]  E. Newman,et al.  Potassium buffering in the central nervous system , 2004, Neuroscience.

[52]  F. Helmchen,et al.  Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo , 2004, Nature Methods.

[53]  Jun Zhou,et al.  Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease , 2004, The Journal of Neuroscience.

[54]  T. Wyss-Coray,et al.  Adult mouse astrocytes degrade amyloid-β in vitro and in situ , 2003, Nature Medicine.

[55]  P. Mcgeer,et al.  The possible role of complement activation in Alzheimer disease. , 2002, Trends in molecular medicine.

[56]  J. Loike,et al.  Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system , 2002, Glia.

[57]  B. Reed,et al.  Very early‐onset familial Alzheimer's disease: a novel presenilin 1 mutation , 2002, International journal of geriatric psychiatry.

[58]  M. Kanje,et al.  Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk‐1 receptor , 2000, The European journal of neuroscience.

[59]  K. Jin,et al.  Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[60]  K. Reid,et al.  C1q: structure, function, and receptors. , 2000, Immunopharmacology.

[61]  G. Lundborg,et al.  Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System , 1999, The Journal of Neuroscience.

[62]  Jae-Wook Oh,et al.  Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor , 1999, The Journal of Neuroscience.

[63]  M. Hediger,et al.  Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate , 1996, Neuron.

[64]  C. Cotman,et al.  beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. , 1994, Journal of immunology.

[65]  A. Messing,et al.  GFAP promoter directs astrocyte-specific expression in transgenic mice , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[66]  L. Mucke,et al.  Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[67]  S. Yamazaki,et al.  Proposal of standardized methods and reference for assaying recombinant human tumor necrosis factor. , 1986, Japanese Journal of Medical Science & Biology.

[68]  T. Frenkel Targeting the Role of Astrocytes in the Progression of Alzheimers Disease , 2012 .

[69]  David Kleinfeld,et al.  MPScope 2.0: A Computer System for Two-Photon Laser Scanning Microscopy with Concurrent Plasma-Mediated Ablation and Electrophysiology , 2009 .

[70]  J. Bauer,et al.  Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients , 2004, Acta Neuropathologica.

[71]  H. Braak,et al.  Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Aβ deposits in the human entorhinal cortex , 2000, Acta Neuropathologica.

[72]  H. Braak,et al.  Staging of Alzheimer-related cortical destruction. , 1997, International psychogeriatrics.

[73]  G. Neufeld,et al.  Vascular endothelial growth factor and its receptors. , 1994, Progress in growth factor research.

[74]  P. Eikelenboom,et al.  An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer’s dementia , 1984, Virchows Archiv. B, Cell pathology including molecular pathology.