Impaired postprandial response of the insulin‐like growth factor system in maintenance haemodialysis

Patients on maintenance haemodialysis (HD) have reduced circulating free and bioactive insulin‐like growth factor I (IGF‐I) due to increased IGF‐binding proteins (IGFBPs). This study investigated the postprandial response of the IGF system in HD patients compared with matched healthy subjects.

[1]  J. Frystyk,et al.  Effect of hyperinsulinemia during hemodialysis on the insulin-like growth factor system and inflammatory biomarkers: a randomized open-label crossover study , 2013, BMC Nephrology.

[2]  K. Smidt,et al.  Measurement of free GH and bioactive IGF-I in non-diabetic haemodialysis patients treated with GH for 7 days. , 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[3]  J. Frystyk.  Quantification of the GH/IGF-axis components: lessons from human studies. , 2012, Domestic animal endocrinology.

[4]  C. Yamada,et al.  Optimal cut‐off point for homeostasis model assessment of insulin resistance to discriminate metabolic syndrome in non‐diabetic Japanese subjects , 2012, Journal of diabetes investigation.

[5]  A. Nakashima,et al.  Postprandial metabolic response to a fat- and carbohydrate-rich meal in patients with chronic kidney disease. , 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[6]  K. Kalantar-Zadeh,et al.  Diets and enteral supplements for improving outcomes in chronic kidney disease , 2011, Nature Reviews Nephrology.

[7]  A. Esteghamati,et al.  Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007) , 2010, Nutrition & metabolism.

[8]  J. Frystyk,et al.  Marked reductions in bioactive insulin-like growth factor I (IGF-I) during hemodialysis. , 2010, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[9]  M. Brugts,et al.  Bioactive rather than total IGF-I is involved in acute responses to nutritional interventions in CAPD patients. , 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[10]  T. Maruyama,et al.  Clinical evaluation of plasma insulin and C-peptide levels with 3 different high-flux dialyzers in diabetic patients on hemodialysis , 2008, The International journal of artificial organs.

[11]  C. Wanner,et al.  A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. , 2008, Kidney international.

[12]  P. Flakoll,et al.  Intradialytic oral nutrition improves protein homeostasis in chronic hemodialysis patients with deranged nutritional status. , 2006, Journal of the American Society of Nephrology : JASN.

[13]  P. Stenvinkel,et al.  Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease? , 2006, European Journal of Clinical Nutrition.

[14]  B. Tönshoff,et al.  Growth hormone/insulin-like growth factor system in children with chronic renal failure , 2005, Pediatric Nephrology.

[15]  R. Selgas,et al.  Growth hormone, IGF‐I and its binding proteins (IGFBP‐1 and ‐3) in adult uraemic patients undergoing peritoneal dialysis and haemodialysis , 2004, Clinical endocrinology.

[16]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[17]  C. Lang,et al.  Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis. , 2003, Endocrinology.

[18]  J. Crowley,et al.  Insulin is protein-anabolic in chronic renal failure patients. , 2003, Journal of the American Society of Nephrology : JASN.

[19]  H. Orskov,et al.  A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum. , 2003, American journal of physiology. Endocrinology and metabolism.

[20]  R. Huisman,et al.  Protein intake during hemodialysis maintains a positive whole body protein balance in chronic hemodialysis patients. , 2003, American journal of physiology. Endocrinology and metabolism.

[21]  M. Joly,et al.  Haemodialysis with the biocompatible high permeability AN-69 membrane does not alter plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3. , 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[22]  H. Orskov,et al.  Serum-free insulin-like growth factor I correlates with clearance in patients with chronic renal failure. , 1999, Kidney international.

[23]  D. Le Roith,et al.  Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. , 1997 .

[24]  D. Le Roith.  Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. , 1997, The New England journal of medicine.

[25]  R. Weindruch,et al.  Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. , 1997, The New England journal of medicine.

[26]  Z. Gucev,et al.  Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. , 1996, The international journal of biochemistry & cell biology.

[27]  E. Barrett,et al.  Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. , 1995, The Journal of clinical investigation.

[28]  T A Ikizler,et al.  Amino acid and albumin losses during hemodialysis. , 1994, Kidney international.

[29]  N. Skakkebaek,et al.  The ratio between serum levels of insulin‐like growth factor (IGF)‐I and the IGF binding proteins (IGFBP‐1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients , 1994, Clinical endocrinology.

[30]  C. Conover,et al.  Regulation and Function of Insulin-Like Growth Factor-Binding Protein-1 , 1993, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[31]  A. Cotterill,et al.  The regulation of insulin‐like growth factor binding protein (IGFBP)‐1 during prolonged fasting , 1993, Clinical endocrinology.

[32]  J. H. Shaw,et al.  The effects of infusion of insulinlike growth factor (IGF) I, IGF-II, and insulin on glucose and protein metabolism in fasted lambs. , 1991, The Journal of clinical investigation.

[33]  V. Grill,et al.  The insulin-like growth factor binding protein-1 in low and high insulin responders before and during dexamethasone treatment. , 1991, Metabolism: clinical and experimental.

[34]  D. Clemmons,et al.  Nutritional regulation of IGF-I and IGF binding proteins. , 1991, Annual review of nutrition.

[35]  R. Rizza,et al.  Lack of Growth Hormone Effect on Insulin-Associated Suppression of Insulinlike Growth Factor Binding Protein 1 in Humans , 1990, Diabetes.

[36]  R. DeFronzo,et al.  Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in uraemia. , 1988, Clinical science.

[37]  A S Detsky,et al.  What is subjective global assessment of nutritional status? , 1987, JPEN. Journal of parenteral and enteral nutrition.