MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation
暂无分享,去创建一个
S. Ventura | Valentín Iglesias | C. Batlle | Isabel Calvo | Marcos Gil-Garcia | M. Serrano | Cian J. Lynch
[1] J. Mymryk,et al. Piggybacking on Classical Import and Other Non-Classical Mechanisms of Nuclear Import Appear Highly Prevalent within the Human Proteome , 2020, Biology.
[2] R. Tjian,et al. Impaired cell fate through gain-of-function mutations in a chromatin reader , 2019, Nature.
[3] J. Fassler,et al. Med15: Glutamine-Rich Mediator Subunit with Potential for Plasticity. , 2019, Trends in biochemical sciences.
[4] Jeroen A. A. Demmers,et al. Mediator complex interaction partners organize the transcriptional network that defines neural stem cells , 2019, Nature Communications.
[5] Simon C. Potter,et al. The EMBL-EBI search and sequence analysis tools APIs in 2019 , 2019, Nucleic Acids Res..
[6] V. Villeret,et al. Twenty years of Mediator complex structural studies , 2019, Biochemical Society transactions.
[7] Do Young Hyeon,et al. Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects , 2018, Proceedings of the National Academy of Sciences.
[8] Salvador Ventura,et al. Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility. , 2018, Molecular pharmaceutics.
[9] G. Kristiansen,et al. The knockdown of the Mediator complex subunit MED15 restrains urothelial bladder cancer cells' malignancy , 2018, Oncology letters.
[10] M. Schölling,et al. Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance , 2018, Molecular and Cellular Biology.
[11] R. Kopito,et al. Prion-Like Characteristics of Polyglutamine-Containing Proteins. , 2018, Cold Spring Harbor perspectives in medicine.
[12] Chenxi Duan,et al. Increased mediator complex subunit 15 expression is associated with poor prognosis in hepatocellular carcinoma , 2018, Oncology letters.
[13] J. Soutourina. Transcription regulation by the Mediator complex , 2017, Nature Reviews Molecular Cell Biology.
[14] S. Ventura,et al. Characterization of Soft Amyloid Cores in Human Prion-Like Proteins , 2017, Scientific Reports.
[15] C. Dobson,et al. Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade. , 2017, Annual review of biochemistry.
[16] J. Shorter,et al. RNA-binding proteins with prion-like domains in health and disease. , 2017, The Biochemical journal.
[17] S. Ventura,et al. Prion-like proteins and their computational identification in proteomes , 2017, Expert review of proteomics.
[18] J. Legleiter,et al. Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease. , 2017, Biochemistry.
[19] Maria Rosario Fernández,et al. Amyloid cores in prion domains: Key regulators for prion conformational conversion , 2017, Prion.
[20] Damian Szklarczyk,et al. The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible , 2016, Nucleic Acids Res..
[21] Maria Rosario Fernández,et al. Characterization of Amyloid Cores in Prion Domains , 2016, Scientific Reports.
[22] D. Borchelt,et al. RAN Translation in Huntington Disease , 2015, Neuron.
[23] Lukasz Kurgan,et al. High-throughput prediction of RNA, DNA and protein binding regions mediated by intrinsic disorder , 2015, Nucleic acids research.
[24] S. Perner,et al. Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors , 2015, Diagnostic Pathology.
[25] Frederic Rousseau,et al. Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity , 2015, Molecular cell.
[26] C. Gustafsson,et al. Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast , 2015, Nucleic acids research.
[27] C. Lengerke,et al. Clinical and molecular implications of MED15 in head and neck squamous cell carcinoma. , 2015, The American journal of pathology.
[28] Joost Schymkowitz,et al. What Makes a Protein Sequence a Prion? , 2015, PLoS Comput. Biol..
[29] Y. Ohkuma,et al. Human mediator subunit MED15 promotes transcriptional activation. , 2014, Drug discoveries & therapeutics.
[30] The Uniprot Consortium,et al. UniProt: a hub for protein information , 2014, Nucleic Acids Res..
[31] Alex Lancaster,et al. PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition , 2014, Bioinform..
[32] Christian Ruiz,et al. MED15, encoding a subunit of the mediator complex, is overexpressed at high frequency in castration‐resistant prostate cancer , 2014, International journal of cancer.
[33] J. Herman,et al. Methylation at the Novel CpG Sites in the Promoter of MED 15 / PCQAP Gene as a Biomarker for Head and Neck Cancers , 2017 .
[34] M. Ishigami,et al. Superb resolution and contrast of transmission electron microscopy images of unstained biological samples on graphene-coated grids. , 2013, Biochimica et biophysica acta.
[35] G. Wang,et al. Mediator MED15 modulates transforming growth factor beta (TGFβ)/Smad signaling and breast cancer cell metastasis. , 2013, Journal of molecular cell biology.
[36] N. Gordon,et al. Unique Features of the Anti-parallel, Heterodimeric Coiled-coil Interaction between Methyl-cytosine Binding Domain 2 (MBD2) Homologues and GATA Zinc Finger Domain Containing 2A (GATAD2A/p66α)* , 2012, The Journal of Biological Chemistry.
[37] Y. Chernoff,et al. Prions in Yeast , 2012, Genetics.
[38] Martin H. Schaefer,et al. Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1 , 2012, PLoS genetics.
[39] Asa Ben-Hur,et al. De novo design of synthetic prion domains , 2012, Proceedings of the National Academy of Sciences.
[40] Silvio C. E. Tosatto,et al. ESpritz: accurate and fast prediction of protein disorder , 2012, Bioinform..
[41] Martin H. Schaefer,et al. Evolution and function of CAG/polyglutamine repeats in protein–protein interaction networks , 2012, Nucleic acids research.
[42] C. Fierke,et al. Transient-state Kinetic Analysis of Transcriptional Activator·DNA Complexes Interacting with a Key Coactivator* , 2011, The Journal of Biological Chemistry.
[43] E. Kandel,et al. Essential Role of Coiled Coils for Aggregation and Activity of Q/N-Rich Prions and PolyQ Proteins , 2010, Cell.
[44] Sohail Malik,et al. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation , 2010, Nature Reviews Genetics.
[45] M. Biancalana,et al. Molecular mechanism of Thioflavin-T binding to amyloid fibrils. , 2010, Biochimica et biophysica acta.
[46] O. King,et al. A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins , 2009, Cell.
[47] Brad T. Sherman,et al. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.
[48] D. Parry,et al. Fifty years of coiled-coils and alpha-helical bundles: a close relationship between sequence and structure. , 2008, Journal of structural biology.
[49] B. Wallace,et al. Protein secondary structure analyses from circular dichroism spectroscopy: methods and reference databases. , 2008, Biopolymers.
[50] R. Wickner,et al. Prions of fungi: inherited structures and biological roles , 2007, Nature Reviews Microbiology.
[51] H. Zoghbi,et al. Trinucleotide repeat disorders. , 2007, Annual review of neuroscience.
[52] Amy E. Keating,et al. Paircoil2: improved prediction of coiled coils from sequence , 2006, Bioinform..
[53] Ronald Wetzel,et al. Oligoproline effects on polyglutamine conformation and aggregation. , 2006, Journal of molecular biology.
[54] Jaime Prilusky,et al. FoldIndex copyright: a simple tool to predict whether a given protein sequence is intrinsically unfolded , 2005, Bioinform..
[55] Susan Lindquist,et al. Prions as adaptive conduits of memory and inheritance , 2005, Nature Reviews Genetics.
[56] Kevin Struhl,et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. , 2004, Molecular cell.
[57] Christopher M Dobson,et al. Exploring amyloid formation by a de novo design. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[58] K. Arndt,et al. Coiled Coil Domains: Stability, Specificity, and Biological Implications , 2004, Chembiochem : a European journal of chemical biology.
[59] S. Teklehaimanot,et al. Potential Biomarkers for Head and Neck Squamous Cell Carcinoma , 2003, The Laryngoscope.
[60] Alasdair C Steven,et al. Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[61] A. Komar,et al. Stability, folding, dimerization, and assembly properties of the yeast prion Ure2p. , 2001, Biochemistry.
[62] D. Chang,et al. Proline affects oligomerization of a coiled coil by inducing a kink in a long helix. , 1999, Journal of structural biology.
[63] A. Lupas,et al. Predicting coiled coils from protein sequences , 1991, Science.
[64] Roger D. Kornberg,et al. A novel mediator between activator proteins and the RNA polymerase II transcription apparatus , 1990, Cell.
[65] F. Winston,et al. The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription , 1989, Molecular and cellular biology.
[66] S. Prusiner. Novel proteinaceous infectious particles cause scrapie. , 1982, Science.
[67] R. Hodges,et al. Amino-acid sequence of rabbit skeletal tropomyosin and its coiled-coil structure. , 1972, Proceedings of the National Academy of Sciences of the United States of America.
[68] G. Kristiansen,et al. The Mediator complex subunit MED15, a promoter of tumour progression and metastatic spread in renal cell carcinoma. , 2018, Cancer biomarkers : section A of Disease markers.
[69] J. Hartgerink,et al. Role of hydrophobic clusters in the stability of alpha-helical coiled coils and their conversion to amyloid-like beta-sheets. , 2007, Biomacromolecules.
[70] J. Beckmann,et al. FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded , 2005 .
[71] C. Ross,et al. Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein. , 2003, Human molecular genetics.
[72] B. Roberts,et al. Yeast prions act as genes composed of self-propagating protein amyloids. , 2001, Advances in protein chemistry.