[Adherence to statin treatment and associated factors in female users from the Unified Health System (SUS)].

OBJECTIVE To identify the adherence rate of a statin treatment and possible related factors in female users from the Unified Health System. METHOD Seventy-one women were evaluated (64.2 ± 11.0 years) regarding the socio-economic level, comorbidities, current medications, level of physical activity, self-report of muscular pain, adherence to the medical prescription, body composition and biochemical profile. The data were analyzed as frequencies, Chi-Squared test, and Mann Whitney test (p<0.05). RESULTS 15.5% of women did not adhere to the medical prescription for the statin treatment, whose had less comorbidities (p=0.01), consumed less quantities of medications (p=0.00), and tended to be younger (p=0.06). Those patients also presented higher values of lipid profile (CT: p=0.01; LDL-c: p=0.02). Musculoskeletal complains were not associated to the adherence rate to the medication. CONCLUSION The associated factors to adherence of dyslipidemic women to statin medical prescription were age, quantity of comorbidities and quantity of current medication.

[1]  S. Heymsfield,et al.  Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES , 2009, PloS one.

[2]  C. Neumann,et al.  The Brief Medication Questionnaire and Morisky-Green test to evaluate medication adherence. , 2012, Revista de saude publica.

[3]  P. Thompson,et al.  The effects of statins on skeletal muscle strength and exercise performance , 2010, Current opinion in lipidology.

[4]  M. Woodward,et al.  Predictors of Nonadherence to Statins: A Systematic Review and Meta-Analysis , 2010, The Annals of pharmacotherapy.

[5]  U. Croti,et al.  [Assessment of the pulmonary vascular blood supply in patients with pulmonary atresia, ventricular septal defect and aortopulmonary collateral arteries]. , 2005, Arquivos brasileiros de cardiologia.

[6]  R. Herings,et al.  Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study. , 2006, European heart journal.

[7]  Rǒmulo Araújo Fernandes,et al.  Associação entre doenças crônicas em adultos e redução dos níveis de atividade física , 2011 .

[8]  M. White,et al.  Impact of better adherence to statin agents in the primary prevention of coronary artery disease , 2009, European Journal of Clinical Pharmacology.

[9]  J. Hayden,et al.  Prospective analysis of LDL-C goal achievement and self-reported medication adherence among statin users in primary care. , 2011, Clinical therapeutics.

[10]  S. Barreto,et al.  IV Diretriz Brasileira sobre Dislipidemias e Prevenção da Aterosclerose: Departamento de Aterosclerose da Sociedade Brasileira de Cardiologia , 2007 .

[11]  W. Borden,et al.  Predictors of Statin Adherence , 2011, Current cardiology reports.

[12]  M. Latorre,et al.  Validation and reliability of the Baecke questionnaire for the evaluation of habitual physical activity in adult men , 2003 .

[13]  Jun Liu,et al.  Patient, Physician, and Payment Predictors of Statin Adherence , 2010, Medical care.

[14]  P. Thompson,et al.  An assessment of statin safety by muscle experts. , 2006, The American journal of cardiology.

[15]  R. Verbrugge,et al.  Impact of Medication Adherence on Hospitalization Risk and Healthcare Cost , 2005, Medical care.

[16]  S. Benemei,et al.  Adherence to statin treatment and health outcomes in an Italian cohort of newly treated patients: results from an administrative database analysis. , 2012, Clinical therapeutics.

[17]  S. Griffiths,et al.  Adherence to lipid‐lowering agents among 11,042 patients in clinical practice , 2011, International journal of clinical practice.

[18]  W. Brown.  Safety of statins. , 2008, Current opinion in lipidology.

[19]  L. Rallidis,et al.  Managing the underestimated risk of statin-associated myopathy. , 2012, International journal of cardiology.

[20]  E. Bruckert,et al.  Mild to Moderate Muscular Symptoms with High-Dosage Statin Therapy in Hyperlipidemic Patients —The PRIMO Study , 2005, Cardiovascular Drugs and Therapy.

[21]  L. Hayman,et al.  Correspondence , 1992, Neuroradiology.

[22]  C. Neumann,et al.  Prueba Morisky-Green y Brief Medication Questionnaire para evaluar adherencia a los medicamentos , 2012 .

[23]  S. Grundy,et al.  ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins. , 2002, Circulation.

[24]  R. Hegele,et al.  Narrative Review: Statin-Related Myopathy , 2009, Annals of Internal Medicine.

[25]  L. Green,et al.  Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence , 1986, Medical care.