Predictive Patient Care: Survival Model to Prevent Medication Non-adherence

Adherence in medicine is a measure of how well a patient follows their treatment. Not following the medication plan is actually a major issue as it was underlined in the World Health Organization’s reports (http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf). They indicated that, in developed countries, only about 50% of patients with chronic diseases correctly follow their treatments. This severely compromises the efficiency of long-term therapy and increases the cost of health services.

[1]  M. Dimatteo,et al.  Social support and patient adherence to medical treatment: a meta-analysis. , 2004, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[2]  M. Woodward,et al.  Predictors of Nonadherence to Statins: A Systematic Review and Meta-Analysis , 2010, The Annals of pharmacotherapy.

[3]  T. Brennan,et al.  Observing versus Predicting: Initial Patterns of Filling Predict Long-Term Adherence More Accurately Than High-Dimensional Modeling Techniques. , 2016, Health services research.

[4]  A. Weill,et al.  French national health insurance information system and the permanent beneficiaries sample. , 2010, Revue d'epidemiologie et de sante publique.

[5]  L. Osterberg,et al.  Adherence to medication. , 2005, The New England journal of medicine.

[6]  C. Twelves,et al.  Oral cancer treatment: developments in chemotherapy and beyond , 2002, British Journal of Cancer.

[7]  D. Cox Regression Models and Life-Tables , 1972 .

[8]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .

[9]  M. Dimatteo,et al.  Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. , 2000, Archives of internal medicine.

[10]  F. Alla,et al.  Pioglitazone and risk of bladder cancer among diabetic patients in France: a population-based cohort study , 2012, Diabetologia.

[11]  Alla Sikorskii,et al.  An Intervention to Improve Adherence and Management of Symptoms for Patients Prescribed Oral Chemotherapy Agents: An Exploratory Study , 2013, Cancer nursing.

[12]  R. Fimmers,et al.  Adherence management for patients with cancer taking capecitabine: a prospective two-arm cohort study , 2013, BMJ Open.

[13]  S. Perera,et al.  Using Machine Learning to Examine Medication Adherence Thresholds and Risk of Hospitalization , 2015, Medical care.

[14]  KyungMann Kim,et al.  Contrasting treatment‐specific survival using double‐robust estimators , 2012 .

[15]  L. Fallowfield,et al.  Patients' preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancer. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.