Grains – a major source of sustainable protein for health

Abstract Cereal grains are the main dietary source of energy, carbohydrates, and plant proteins world-wide. Currently, only 41% of grains are used for human consumption, and up to 35% are used for animal feed. Cereals have been overlooked as a source of environmentally sustainable and healthy plant proteins and could play a major role in transitioning towards a more sustainable food system for healthy diets. Cereal plant proteins are of good nutritional quality, but lysine is often the limiting amino acid. When consumed as whole grains, cereals provide health-protecting components such as dietary fiber and phytochemicals. Shifting grain use from feed to traditional foods and conceptually new foods and ingredients could improve protein security and alleviate climate change. Rapid development of new grain-based food ingredients and use of grains in new food contexts, such as dairy replacements and meat analogues, could accelerate the transition. This review discusses recent developments and outlines future perspectives for cereal grain use.

[1]  M. T. Knudsen,et al.  Potential to reduce GHG emissions and land use by substituting animal-based proteins by foods containing oat protein concentrate , 2020 .

[2]  E. Nordlund,et al.  The role of rye bran acidification and in situ dextran formation on structure and texture of high fibre extrudates. , 2020, Food research international.

[3]  O. Pedersen,et al.  Gut microbiota in human metabolic health and disease , 2020, Nature Reviews Microbiology.

[4]  K. Miller.  Review of whole grain and dietary fiber recommendations and intake levels in different countries. , 2020, Nutrition reviews.

[5]  Yifang Chu,et al.  Global review of whole grain definitions and health claims. , 2020, Nutrition reviews.

[6]  P. Jakeman,et al.  Separating the Wheat from the Chaff: Nutritional Value of Plant Proteins and Their Potential Contribution to Human Health , 2020, Nutrients.

[7]  E. Nordlund,et al.  Phytase treatment of a protein-enriched rice bran fraction improves heat-induced gelation properties at alkaline conditions , 2020 .

[8]  N. Sozer,et al.  Impact of Ultrasound Treatment and pH-Shifting on Physicochemical Properties of Protein-Enriched Barley Fraction and Barley Protein Isolate , 2020, Foods.

[9]  Y. Xiong,et al.  Plant protein-based alternatives of reconstructed meat: Science, technology, and challenges , 2020 .

[10]  J. Pihlajamäki,et al.  Dietary Fiber from Oat and Rye Brans Ameliorate Western Diet-Induced Body Weight Gain and Hepatic Inflammation by the Modulation of Short Chain Fatty Acids, Bile Acids, and Tryptophan Metabolism. , 2020, Molecular nutrition & food research.

[11]  Guangjing Chen,et al.  Effects of multi-frequency ultrasound on physicochemical properties, structural characteristics of gluten protein and the quality of noodle. , 2020, Ultrasonics sonochemistry.

[12]  T. Lawson,et al.  From green to gold: agricultural revolution for food security. , 2020, Journal of experimental botany.

[13]  Outi-Maaria Palo-oja,et al.  Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources , 2020, Nutrients.

[14]  P. Shen,et al.  Associations of dietary protein intake with all-cause, cardiovascular disease, and cancer mortality: A systematic review and meta-analysis of cohort studies. , 2020, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[15]  H. Stein,et al.  Most meat products have digestible indispensable amino acid scores that are greater than 100, but processing may increase or reduce protein quality , 2020, British Journal of Nutrition.

[16]  P. Goos,et al.  Study into the effect of microfluidisation processing parameters on the physicochemical properties of wheat (Triticum aestivum L.) bran. , 2020, Food chemistry.

[17]  Albert-László Barabási,et al.  The unmapped chemical complexity of our diet , 2019, Nature Food.

[18]  B. Bohrer.  An investigation of the formulation and nutritional composition of modern meat analogue products , 2019 .

[19]  B. Carciofi,et al.  Food processing for the improvement of plant proteins digestibility , 2019, Critical reviews in food science and nutrition.

[20]  Narasimha D. Rao,et al.  Assessing the sustainability of post-Green Revolution cereals in India , 2019, Proceedings of the National Academy of Sciences.

[21]  C. Wittmann,et al.  Fermentation of plant-based milk alternatives for improved flavour and nutritional value , 2019, Applied Microbiology and Biotechnology.

[22]  S. Drusch,et al.  Towards an increased plant protein intake: Rheological properties, sensory perception and consumer acceptability of lactic acid fermented, oat-based gels , 2019, Food Hydrocolloids.

[23]  D. Duță,et al.  Oat protein concentrate as alternative ingredient for non-dairy yoghurt-type product. , 2019, Journal of the science of food and agriculture.

[24]  R. Portmann,et al.  Protein profile of dairy products: Simultaneous quantification of twenty bovine milk proteins , 2019, International Dairy Journal.

[25]  A. Page,et al.  The gut microbiome regulates host glucose homeostasis via peripheral serotonin , 2019, Proceedings of the National Academy of Sciences.

[26]  K. Poutanen,et al.  Biochemical and Techno-Functional Properties of Protein- and Fibre-Rich Hybrid Ingredients Produced by Dry Fractionation from Rice Bran , 2019, Food and Bioprocess Technology.

[27]  C. Gianfrani,et al.  E40, a novel microbial protease efficiently detoxifying gluten proteins, for the dietary management of gluten intolerance , 2019, Scientific Reports.

[28]  E. Trolle,et al.  Environmental Sustainability Perspectives of the Nordic Diet , 2019, Nutrients.

[29]  P. Bingley,et al.  Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk. , 2019, JAMA.

[30]  L. G. Vu,et al.  Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 , 2019, The Lancet.

[31]  M. Arimond,et al.  A Global Review of Food-Based Dietary Guidelines , 2019, Advances in nutrition.

[32]  M. Gulati,et al.  Dietary components and risk of cardiovascular disease and all-cause mortality: a review of evidence from meta-analyses , 2019, European journal of preventive cardiology.

[33]  A. Rajabzadeh,et al.  Dry fractionation methods for plant protein, starch and fiber enrichment: A review , 2019, Trends in Food Science & Technology.

[34]  S. Loveday.  Food Proteins: Technological, Nutritional, and Sustainability Attributes of Traditional and Emerging Proteins. , 2019, Annual review of food science and technology.

[35]  W. Willett,et al.  Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems , 2019, The Lancet.

[36]  L. T. Te Morenga,et al.  Carbohydrate quality and human health: a series of systematic reviews and meta-analyses , 2019, The Lancet.

[37]  A. Galieni,et al.  Sprouted Grains: A Comprehensive Review , 2019, Nutrients.

[38]  K. Venema,et al.  Gut microbial metabolites in obesity, NAFLD and T2DM , 2019, Nature Reviews Endocrinology.

[39]  J. Delcour,et al.  Impact of Cereal Seed Sprouting on Its Nutritional and Technological Properties: A Critical Review. , 2018, Comprehensive reviews in food science and food safety.

[40]  C. Müller,et al.  Climate change impact and adaptation for wheat protein , 2018, Global change biology.

[41]  T. R. Licht,et al.  A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults , 2018, Nature Communications.

[42]  Liuping Fan,et al.  Digestible indispensable amino acid scores of nine cooked cereal grains , 2018, British Journal of Nutrition.

[43]  Remko M. Boom,et al.  Structuring processes for meat analogues , 2018, Trends in Food Science & Technology.

[44]  Yujuan Zhang,et al.  Wheat grain protein accumulation and polymerization mechanisms driven by nitrogen fertilization. , 2018, The Plant journal : for cell and molecular biology.

[45]  Emmanuel Ayua,et al.  Fermentation and germination improve nutritional value of cereals and legumes through activation of endogenous enzymes , 2018, Food science & nutrition.

[46]  P. Barbillon,et al.  Patterns of plant and animal protein intake are strongly associated with cardiovascular mortality: the Adventist Health Study-2 cohort. , 2018, International journal of epidemiology.

[47]  S. Doucette,et al.  Comparative effects of different whole grains and brans on blood lipid: a network meta-analysis , 2018, European Journal of Nutrition.

[48]  F. Haghighatdoost,et al.  Effects of Whole-Grain Consumption on Selected Biomarkers of Systematic Inflammation: A Systematic Review and Meta-analysis of Randomized Controlled Trials , 2018, Journal of the American College of Nutrition.

[49]  Kun Wu,et al.  Modulating plant growth-metabolism coordination for sustainable agriculture , 2018, Nature.

[50]  M. Paulsson,et al.  Transglutaminases in autoimmune and inherited skin diseases: The phenomena of epitope spreading and functional compensation , 2018, Experimental dermatology.

[51]  G. Kramer,et al.  Comparing the Performance of Bread and Breakfast Cereals, Dairy, and Meat in Nutritionally Balanced and Sustainable Diets , 2018, Frontiers in Nutrition.

[52]  T. Nemecek,et al.  Reducing food’s environmental impacts through producers and consumers , 2018, Science.

[53]  R. Ball,et al.  Metabolic Availability of the Limiting Amino Acids Lysine and Tryptophan in Cooked White African Cornmeal Assessed in Healthy Young Men Using the Indicator Amino Acid Oxidation Technique. , 2018, The Journal of nutrition.

[54]  S. Mahatheeranont,et al.  Some Strategies for Utilization of Rice Bran Functional Lipids and Phytochemicals. , 2018, Journal of oleo science.

[55]  Ahmed S. M. Saleh,et al.  Technologies for enhancement of bioactive components and potential health benefits of cereal and cereal-based foods: Research advances and application challenges , 2018, Critical reviews in food science and nutrition.

[56]  M. Mohammadifar,et al.  Effect of ultrasound treatments on functional properties and structure of millet protein concentrate. , 2018, Ultrasonics sonochemistry.

[57]  M. Nydahl,et al.  Consumers’ health-related perceptions of bread – Implications for labeling and health communication , 2018, Appetite.

[58]  J. Boer,et al.  Prospects for pro-environmental protein consumption in Europe: Cultural, culinary, economic and psychological factors , 2018, Appetite.

[59]  Cheryl Taylor,et al.  Effects of chemical composition and baking on in vitro digestibility of proteins in breads made from selected gluten-containing and gluten-free flours. , 2017, Food chemistry.

[60]  A. Pulvirenti,et al.  Re-challenge Studies in Non-celiac Gluten Sensitivity: A Systematic Review and Meta-Analysis , 2017, Front. Physiol..

[61]  G. Grosso,et al.  Whole Grain Intake and Glycaemic Control in Healthy Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2017, Nutrients.

[62]  R. Landberg,et al.  Whole grain oats, more than just a fiber: Role of unique phytochemicals , 2017, Molecular nutrition & food research.

[63]  Antonios Drakos,et al.  Protein isolation from jet milled rye flours differing in particle size , 2017 .

[64]  R. Landberg,et al.  Phytochemicals in whole grain wheat and their health‐promoting effects , 2017, Molecular nutrition & food research.

[65]  Rikard Landberg,et al.  Microbial and endogenous metabolic conversions of rye phytochemicals , 2017, Molecular nutrition & food research.

[66]  Chenyang Wang,et al.  Effect of irrigation and nitrogen application on grain amino acid composition and protein quality in winter wheat , 2017, PloS one.

[67]  G. Galili,et al.  Fortifying Horticultural Crops with Essential Amino Acids: A Review , 2017, International journal of molecular sciences.

[68]  Jussi Paananen,et al.  Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study , 2017, Scientific Reports.

[69]  E. Nordlund,et al.  Bioprocessing of bran with exopolysaccharide producing microorganisms as a tool to improve expansion and textural properties of extruded cereal foams with high dietary fibre content , 2017 .

[70]  N. Scheers,et al.  Towards Celiac-safe foods: Decreasing the affinity of transglutaminase 2 for gliadin by addition of ascorbyl palmitate and ZnCl2 as detoxifiers , 2017, Scientific Reports.

[71]  T. Dinan,et al.  The Microbiome-Gut-Brain Axis in Health and Disease. , 2017, Gastroenterology Clinics of North America.

[72]  C. Mackay,et al.  Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells , 2017, The Journal of Immunology.

[73]  H. Stein,et al.  Values for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values calculated using the concept for protein digestibility-corrected amino acid scores (PDCAAS) , 2017, British Journal of Nutrition.

[74]  Jolon M. Dyer,et al.  Cooking-Induced Protein Modifications in Meat. , 2017, Comprehensive reviews in food science and food safety.

[75]  D. Mcclements,et al.  Effect of limited enzymatic hydrolysis on structure and emulsifying properties of rice glutelin , 2016 .

[76]  M. Niva,et al.  From beef to beans: Eating motives and the replacement of animal proteins with plant proteins among Finnish consumers , 2016, Appetite.

[77]  Mingyang Song,et al.  Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. , 2016, JAMA internal medicine.

[78]  Swati Sethi,et al.  Plant-based milk alternatives an emerging segment of functional beverages: a review , 2016, Journal of Food Science and Technology.

[79]  Simone Pettigrew,et al.  Pleasure: An under-utilised ‘P’ in social marketing for healthy eating , 2016, Appetite.

[80]  Michael Clark,et al.  The environmental impacts of food production , 2016 .

[81]  G. Mahunu,et al.  Effects of ultrasound and ultrasound assisted alkaline pretreatments on the enzymolysis and structural characteristics of rice protein. , 2016, Ultrasonics sonochemistry.

[82]  E. Arendt,et al.  Foods for Special Dietary Needs: Non-dairy Plant-based Milk Substitutes and Fermented Dairy-type Products , 2016, Critical reviews in food science and nutrition.

[83]  A. Cianferoni.  Wheat allergy: diagnosis and management , 2016, Journal of asthma and allergy.

[84]  Christian Schader,et al.  Impacts of feeding less food-competing feedstuffs to livestock on global food system sustainability , 2015, Journal of The Royal Society Interface.

[85]  Peilin Shi,et al.  Global, regional and national consumption of major food groups in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys worldwide , 2015, BMJ Open.

[86]  R. Levy,et al.  Dietary guidelines to nourish humanity and the planet in the twenty-first century. A blueprint from Brazil , 2015, Public Health Nutrition.

[87]  P. Shewry,et al.  A novel approach to identify genes that determine grain protein deviation in cereals. , 2015, Plant biotechnology journal.

[88]  J. Delcour,et al.  Extractability and chromatographic characterization of wheat (triticum aestivum l.) bran protein. , 2015, Journal of food science.

[89]  Seong-Jun Cho,et al.  Nutritional quality of rice bran protein in comparison to animal and vegetable protein. , 2015, Food chemistry.

[90]  J. Sonnenburg,et al.  Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[91]  Haile Ma,et al.  Effects of a Dual-Frequency Frequency-Sweeping Ultrasound Treatment on the Properties and Structure of the Zein Protein , 2015 .

[92]  N. Scheers,et al.  Sourdough Fermentation of Wheat Flour does not Prevent the Interaction of Transglutaminase 2 with α2-Gliadin or Gluten , 2015, Nutrients.

[93]  J. Curiel,et al.  Effect of bioprocessing and particle size on the nutritional properties of wheat bran fractions , 2014 .

[94]  H. Stein,et al.  Digestible indispensable amino acid score and digestible amino acids in eight cereal grains , 2014, British Journal of Nutrition.

[95]  R. Liu,et al.  Health Benefits of Oat Phytochemicals , 2013 .

[96]  C. Mulder,et al.  Vitamin and Mineral Deficiencies Are Highly Prevalent in Newly Diagnosed Celiac Disease Patients , 2013, Nutrients.

[97]  L. Day.  Proteins from land plants – Potential resources for human nutrition and food security , 2013 .

[98]  A. Aura,et al.  Changes in bran structure by bioprocessing with enzymes and yeast modifies the in vitro digestibility and fermentability of bran protein and dietary fibre complex , 2013 .

[99]  R. Ball,et al.  Lysine from cooked white rice consumed by healthy young men is highly metabolically available when assessed using the indicator amino acid oxidation technique. , 2013, The Journal of nutrition.

[100]  Wei Sun,et al.  The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. , 2012, Molecular cell.

[101]  J. Bruinsma,et al.  World agriculture towards 2030/2050: the 2012 revision , 2012 .

[102]  P. Gibson,et al.  Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals? , 2012, Therapeutic advances in gastroenterology.

[103]  D. Keast,et al.  Dietary modeling shows that substitution of whole-grain for refined-grain ingredients of foods commonly consumed by US children and teens can increase intake of whole grains. , 2011, Journal of the American Dietetic Association.

[104]  A. J. van der Goot,et al.  The potential of dry fractionation processes for sustainable plant protein production , 2011 .

[105]  C. Rizzello,et al.  Gluten-free Sourdough Wheat Baked Goods Appear Safe for Young Celiac Patients: A Pilot Study , 2010, Journal of pediatric gastroenterology and nutrition.

[106]  J. Murray,et al.  Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. , 2010, Gastroenterology.

[107]  J. Boye,et al.  Pulse proteins: Processing, characterization, functional properties and applications in food and feed , 2010 .

[108]  K. Poutanen,et al.  Sourdough and cereal fermentation in a nutritional perspective. , 2009, Food microbiology.

[109]  J. Delcour,et al.  Wheat gluten amino acid composition analysis by high-performance anion-exchange chromatography with integrated pulsed amperometric detection. , 2009, Journal of chromatography. A.

[110]  Ian J. Brown,et al.  Salt intakes around the world: implications for public health. , 2009, International journal of epidemiology.

[111]  J. Buchert,et al.  Effects of laccase and xylanase on the chemical and rheological properties of oat and wheat doughs. , 2008, Journal of agricultural and food chemistry.

[112]  Nitika,et al.  Physico-chemical characteristics, nutrient composition and consumer acceptability of wheat varieties grown under organic and inorganic farming conditions , 2008, International journal of food sciences and nutrition.

[113]  A. Brunger,et al.  Transglutaminase 2 Undergoes a Large Conformational Change upon Activation , 2007, PLoS biology.

[114]  Peter R. Shewry,et al.  Improving the protein content and composition of cereal grain , 2007 .

[115]  J. Schnürer,et al.  Rhizopus oligosporus and yeast co-cultivation during barley tempeh fermentation--nutritional impact and real-time PCR quantification of fungal growth dynamics. , 2007, Food microbiology.

[116]  Marie A G Alminger,et al.  Reduction of phytate content while preserving minerals during whole grain cereal tempe fermentation , 2006 .

[117]  B. Mckevith.  Nutritional aspects of cereals , 2004 .

[118]  Jorma Ilonen,et al.  Prevalence of Celiac disease among children in Finland. , 2003, The New England journal of medicine.

[119]  P. Shewry,et al.  Cereal seed storage proteins: structures, properties and role in grain utilization. , 2002, Journal of experimental botany.

[120]  B. Hamaker,et al.  A highly digestible sorghum mutant cultivar exhibits a unique folded structure of endosperm protein bodies. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[121]  G. García-Casado,et al.  Rye flour allergens associated with baker's asthma. Correlation between in vivo and in vitro activities and comparison with their wheat and barley homologues , 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[122]  H. Ten Have,et al.  Fao , 1950, Social Service Review.

[123]  E. Nordlund,et al.  Limited hydrolysis of rice endosperm protein for improved techno-functional properties. , 2019, Food chemistry.

[124]  A. Goto,et al.  Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality in a Japanese Cohort. , 2019, JAMA internal medicine.

[125]  Jian Zhao,et al.  In vitro digestion of rice bran proteins produces peptides with potent inhibitory effects on α-glucosidase and angiotensin I converting enzyme. , 2018, Journal of the science of food and agriculture.

[126]  P. Mattila,et al.  Flavonoids, anthocyanins, phenolamides, benzoxazinoids, lignans and alkylresorcinols in rye (Secale cereale) and some rye products , 2018 .

[127]  F. Respondek,et al.  Proteins From Wheat: Sustainable Production and New Developments in Nutrition-Based and Functional Applications , 2017 .

[128]  J.R.N. Taylor,et al.  Proteins From Sorghum and Millets , 2017 .

[129]  Khalid Rehman Hakeem,et al.  Sustainable Crop Production System , 2016 .

[130]  H. L. Kock,et al.  Sensory characteristics of wholegrain and bran-rich cereal foods: A review , 2016 .

[131]  A. Ross,et al.  Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies. , 2015, The American journal of clinical nutrition.

[132]  Hitoshi Takahashi,et al.  Food-Dependent Exercise-Induced Anaphylaxis-Importance of Omega-5 Gliadin and HMW-Glutenin as Causative Antigens for Wheat-Dependent Exercise-Induced Anaphylaxis. , 2009, Allergology international : official journal of the Japanese Society of Allergology.

[133]  Zhengxing Chen,et al.  Effect of heat, rutin and disulfide bond reduction on in vitro pepsin digestibility of Chinese tartary buckwheat protein fractions , 2007 .

[134]  J. Prakash,et al.  Effect of stabilization of rice bran on the extractability and recovery of proteins , 1994 .

[135]  K. Hachmeister,et al.  Tempeh: a mold-modified indigenous fermented food made from soybeans and/or cereal grains. , 1993, Critical reviews in microbiology.