Neuropsychiatric disturbances in mild cognitive impairment: A scientometric analysis

Behavioral and psychological symptoms of dementia (BPSD) have been extensively studied in dementia than its prodromal stage, known as mild cognitive impairment (MCI). A scientometric study on BPSD in MCI would be valuable in synthesizing the existing body of research and provide insights into the trends, networks, and influencers within this area. We searched for related literature in the Web of Science database and extracted complete text and citation records of each publication. The primary objective was to map the research evolution of BPSD in MCI and highlight dominant research themes. The secondary objective was to identify research network characteristics (authors, journals, countries, and institutions) and abundances. A total of 12,369 studies published between 1980 to 2022 were included in the analysis. We found 51 distinct clusters from the co-cited reference network that were highly credible with significant modularity (Q = 0.856) and silhouette scores (S = 0.932). Five major research domains were identified: symptoms, diagnosis, brain substrates, biochemical pathways, and interventions. Within recent years, the research focus in this area is on gut microbiota, e-health, COVID-19, cognition, and delirium. Collectively, findings from this scientometric analysis can help clarify the scope and direction of future research and clinical practices.

[1]  L. Sacco,et al.  Emotion recognition and processing in patients with mild cognitive impairment: A systematic review , 2022, Frontiers in Psychology.

[2]  P. Davis,et al.  Comorbidity‐driven multi‐modal subtype analysis in mild cognitive impairment of Alzheimer's disease , 2022, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[3]  T. Wongpakaran,et al.  Impact of behavioral and psychological symptoms of Alzheimer’s disease on caregiver outcomes , 2022, Scientific Reports.

[4]  K. Satoh,et al.  Factors Associated with Behavioral and Psychological Symptoms of Dementia during COVID-19 , 2022, International journal of environmental research and public health.

[5]  Jing-Xue Ma,et al.  Dysfunction of Emotion Regulation in Mild Cognitive Impairment Individuals Combined With Depressive Disorder: A Neural Mechanism Study , 2022, Frontiers in Aging Neuroscience.

[6]  P. Braga-Neto,et al.  COVID-19 associated cognitive impairment: A systematic review , 2022, Cortex.

[7]  Chaomei Chen,et al.  Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends , 2022, Neuroscience & Biobehavioral Reviews.

[8]  K. Uchida,et al.  Prevalence of Behavioral and Psychological Symptoms in Patients With Cognitive Decline Before and During the COVID-19 Pandemic , 2022, Frontiers in Psychiatry.

[9]  Kimberly A. Lewis,et al.  Cognitive Impairment in Non-critical, Mild-to-Moderate COVID-19 Survivors , 2022, Frontiers in Psychology.

[10]  O. Andreassen,et al.  Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment and Alzheimer’s disease with dementia , 2021, International Psychogeriatrics.

[11]  C. Schönfeldt-Lecuona,et al.  Efficacy and safety of pharmacotherapy for Alzheimer’s disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials , 2021, Alzheimer's Research & Therapy.

[12]  Xiaobei Zhou,et al.  A probabilistic model for co-occurrence analysis in bibliometrics , 2021, J. Biomed. Informatics.

[13]  Yaojing Chen,et al.  Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer’s disease: a systematic review of symptom-general and –specific lesion patterns , 2021, Molecular Neurodegeneration.

[14]  M. Zeegers,et al.  Citation bias and other determinants of citation in biomedical research: findings from six citation networks. , 2020, Journal of clinical epidemiology.

[15]  M. Vakhrushev.  Altmetrics, webometrics and informetrics as the complementary vectors in the modern bibliometrics , 2019, Scientific and Technical Libraries.

[16]  S. Niida,et al.  Malnutrition is Associated with Behavioral and Psychiatric Symptoms of Dementia in Older Women with Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease , 2019, Nutrients.

[17]  Shinichi Nakagawa,et al.  Research Weaving: Visualizing the Future of Research Synthesis. , 2018, Trends in ecology & evolution.

[18]  R. Ihl,et al.  Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761® , 2019, CNS neuroscience & therapeutics.

[19]  G. Andersson,et al.  Internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: an updated systematic review and meta-analysis , 2018, Cognitive behaviour therapy.

[20]  T. Paunio,et al.  European guideline for the diagnosis and treatment of insomnia , 2017, Journal of sleep research.

[21]  M. Crotty,et al.  An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia , 2017, International Psychogeriatrics.

[22]  Massimo Aria,et al.  bibliometrix: An R-tool for comprehensive science mapping analysis , 2017, J. Informetrics.

[23]  G. Alves,et al.  Neuropsychiatric Disturbances in Mild Cognitive Impairment (MCI): A Systematic Review of Population-Based Studies. , 2016, Current Alzheimer research.

[24]  Neal R. Haddaway,et al.  A methodology for systematic mapping in environmental sciences , 2016, Environmental Evidence.

[25]  Jian Wang,et al.  Bias Against Novelty in Science: A Cautionary Tale for Users of Bibliometric Indicators , 2015 .

[26]  A. Spector,et al.  Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis† , 2015, British Journal of Psychiatry.

[27]  M. Chakravarty,et al.  Lifetime History of Depression Predicts Increased Amyloid-β Accumulation in Patients with Mild Cognitive Impairment. , 2015, Journal of Alzheimer's Disease.

[28]  Ivan Zupic,et al.  Bibliometric Methods in Management and Organization , 2014 .

[29]  Ronald C. Petersen,et al.  Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics , 2013, PloS one.

[30]  A. Verkhratsky,et al.  The serotonergic system in ageing and Alzheimer's disease , 2012, Progress in Neurobiology.

[31]  Masatoshi Takeda,et al.  [Behavioral and psychological symptoms of dementia]. , 2011, Nihon rinsho. Japanese journal of clinical medicine.

[32]  Jianhua Hou,et al.  The structure and dynamics of cocitation clusters: A multiple-perspective cocitation analysis , 2010, J. Assoc. Inf. Sci. Technol..

[33]  Ludo Waltman,et al.  Software survey: VOSviewer, a computer program for bibliometric mapping , 2009, Scientometrics.

[34]  I. McKeith,et al.  Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population , 2009, British Journal of Psychiatry.

[35]  Y. Gustafson,et al.  Behavioral and psychological symptoms of dementia in relation to level of cognitive impairment , 2008, International Psychogeriatrics.

[36]  Sterling C. Johnson,et al.  Magnetic Resonance Imaging Characterization of Brain Structure and Function in Mild Cognitive Impairment: A Review , 2008, Journal of the American Geriatrics Society.

[37]  L. Egghe,et al.  Theory and practise of the g-index , 2006, Scientometrics.

[38]  Chaomei Chen,et al.  CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature , 2006, J. Assoc. Inf. Sci. Technol..

[39]  I. McKeith,et al.  Behavioural changes and psychological symptoms in dementia disorders , 2005, The Lancet Neurology.

[40]  Naomi Yatomi,et al.  Influence of Deteriorating Ability of Emotional Comprehension on Interpersonal Behavior in Alzheimer-Type Dementia , 2001, Brain and Cognition.

[41]  G. Frisoni,et al.  Behavioral Syndromes in Alzheimer’s Disease: Description and Correlates , 1999, Dementia and Geriatric Cognitive Disorders.

[42]  S. Finkel,et al.  Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment , 1997, International Psychogeriatrics.

[43]  P. Rousseeuw.  Silhouettes: a graphical aid to the interpretation and validation of cluster analysis , 1987 .

[44]  Henry G. Small,et al.  Co-citation in the scientific literature: A new measure of the relationship between two documents , 1973, J. Am. Soc. Inf. Sci..

[45]  Hoss Belyadi,et al.  Unsupervised machine learning: clustering algorithms , 2021, Machine Learning Guide for Oil and Gas Using Python.

[46]  Derek L. Hansen,et al.  Calculating and visualizing network metrics , 2020, Analyzing Social Media Networks with NodeXL.

[47]  K. Boyack,et al.  Co-citation analysis, bibliographic coupling, and direct citation: Which citation approach represents the research front most accurately? , 2010, J. Assoc. Inf. Sci. Technol..

[48]  Ming-Jang Chiu,et al.  Behavioral and psychologic symptoms in different types of dementia. , 2006, Journal of the Formosan Medical Association = Taiwan yi zhi.

[49]  S. Sy,et al.  Large Scale Interactive Analysis BEng . Computing Final Year Project , 2001 .