Heat dissipation mechanism of magnetite nanoparticles in magnetic fluid hyperthermia

Abstract The relative contributions of Neel and Brownian relaxations on magnetic heat dissipation were studied by investigating the physical, magnetic and heating characteristics of magnetite nanoparticle suspensions with average diameters of 12.5 and 15.7 nm. Heating characteristics depended on the dispersion states of particles. The specific absorption rates (SAR) dropped by 27% for the 12.5 nm particles to 16.8×10−9 W g−1 Oe−2 Hz−1 and by 67% for the 15.7 nm particles to 9.69×10−9 W g−1 Oe−2 Hz−1, when the particle rotation was suppressed by dispersing magnetite nanoparticles in hydro-gel.

[1]  B. Jeyadevan,et al.  Heating efficiency of magnetite particles exposed to AC magnetic field , 2007 .

[2]  P. Wust,et al.  Hyperthermia in combined treatment of cancer. , 2002, The Lancet Oncology.

[3]  Jean-Paul Fortin,et al.  Intracellular heating of living cells through Néel relaxation of magnetic nanoparticles , 2008, European Biophysics Journal.

[4]  R. E. Rosensweig,et al.  Heating magnetic fluid with alternating magnetic field , 2002 .

[5]  P. Wust,et al.  Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles , 1999 .

[6]  R. Gilchrist,et al.  Selective Inductive Heating of Lymph Nodes , 1957, Annals of surgery.

[7]  R. Muller,et al.  Preparation of magnetic nanoparticles with large specific loss power for heating applications , 2005 .

[8]  Ingrid Hilger,et al.  Heating potential of iron oxides for therapeutic purposes in interventional radiology. , 2002, Academic radiology.

[9]  H. Gu,et al.  Magnetite ferrofluid with high specific absorption rate for application in hyperthermia , 2007 .

[10]  Koichi Murakami,et al.  Temperature-sensitive amorphous magnetic flakes for intratissue hyperthermia , 1994 .

[11]  Makoto Ohta,et al.  Poly-vinyl alcohol hydrogel vascular models for in vitro aneurysm simulations: the key to low friction surfaces. , 2004, Technology and health care : official journal of the European Society for Engineering and Medicine.

[12]  Peter Wust,et al.  Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme , 2006, Journal of Neuro-Oncology.

[13]  P Wust,et al.  Clinical hyperthermia of prostate cancer using magnetic nanoparticles: Presentation of a new interstitial technique , 2005, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[14]  P. Moroz,et al.  Status of hyperthermia in the treatment of advanced liver cancer , 2001, Journal of Surgical Oncology.

[15]  J. Bacri,et al.  Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. , 2007, Journal of the American Chemical Society.