Idiopathic edema in a male.

A 15-year-old boy who suffered from leg edema of unknown origin is described. The exclusion of any other cause for the edema, the clinical features, and the results of the dynamic tests performed suggested the diagnosis of "idiopathic edema," a syndrome described previously in women only. Spironolactone therapy brought about the disappearance of the edema and enabled the patient to return to his normal activities. This case report suggests that "idiopathic edema" is a syndrome common to both sexes, and is therefore not related to estrogen disturbances.

[1]  N. Pozet,et al.  [Idiopathic cyclic edema: disorders in water elimination accentuated by orthostasis]. , 1977, La Nouvelle presse medicale.

[2]  T. Unger,et al.  Catecholamine excretion in "idiopathic" edema: decreased dopamine excretion, a pathogenic factor? , 1977, The Journal of clinical endocrinology and metabolism.

[3]  J Genest,et al.  Urinary and plasma cyclic adenosine 3',5'-monophosphate in patients with idiopathic edema. , 1975, The Journal of clinical endocrinology and metabolism.

[4]  A. Barbeau,et al.  Relationship between the adrenergic nervous system and renin during adaptation to upright posture: a possible role for 3,4-dihydroxyphenethylamine (dopamine). , 1972, Clinical science.

[5]  J. O. Davis,et al.  Effects of estrogens and progesterone on electrolyte balances in normal dogs. , 1970, The American journal of physiology.

[6]  J. Kopecká,et al.  Inappropriate response to upright posture: a precipitating factor in the pathogenesis of idiopathic edema. , 1970, Annals of internal medicine.

[7]  M. Horwith,et al.  Idiopathic edema. Studies demonstrating protein-leaking angiopathy. , 1970, The American journal of medicine.

[8]  G. W. Thorn.  Approach to the patient with "idiopathic edema" or "periodic swelling". , 1968, JAMA.

[9]  E. A. Sims,et al.  The relation of capillary angiopathy and diabetes mellitus to idiopathic edema. , 1965, Annals of internal medicine.

[10]  N. Assali,et al.  Effects of estrogens on renal hemodynamics and excretion of electrolytes in human subjects. , 1956, The Journal of clinical endocrinology and metabolism.

[11]  S. Zuckerman,et al.  Factors in sexual‐skin oedema , 1938, The Journal of physiology.

[12]  G. W. Thorn,et al.  THE EFFECT OF SEX HORMONES ON THE RENAL EXCRETION OF ELECTROLYTES , 1938, The Journal of experimental medicine.

[13]  M. Weinberger,et al.  The effect of posture and saline loading on plasma renin activity and aldosterone concentration in pregnant, non-pregnant and estrogen-treated women. , 1977, The Journal of clinical endocrinology and metabolism.

[14]  N. Pozet,et al.  Oedème cyclique idiopathique: trouble de l'élimination hydrique à majoration orthostatique , 1977 .

[15]  J. Williams,et al.  Studies of the mechanism of sodium retention in idiopathic edema. , 1973, Transactions of the Association of American Physicians.