Data-driven supervised learning of a viral protease specificity landscape from deep sequencing and molecular simulations
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[1] J. Cristina,et al. Hepatitis C virus genetic variability in patients undergoing antiviral therapy. , 2007, Virus research.
[2] Claus O. Wilke,et al. Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution , 2008, Cell.
[3] D. Fairlie,et al. Proteases universally recognize beta strands in their active sites. , 2005, Chemical reviews.
[4] E. Domingo,et al. RNA virus mutations and fitness for survival. , 1997, Annual review of microbiology.
[5] M. Eigen,et al. Viral quasispecies. , 1993, Scientific American.
[6] A. Chakraborty,et al. Deconstruction of the Ras switching cycle through saturation mutagenesis , 2017, eLife.
[7] H. Kräusslich,et al. Gag Mutations Strongly Contribute to HIV-1 Resistance to Protease Inhibitors in Highly Drug-Experienced Patients besides Compensating for Fitness Loss , 2009, PLoS pathogens.
[8] R. Ernst. Large Igneous Provinces , 2014, Encyclopedia of Geology.
[9] Elena R. Lozovsky,et al. Biophysical principles predict fitness landscapes of drug resistance , 2016, Proceedings of the National Academy of Sciences.
[10] Sagar D. Khare,et al. MFPred: Rapid and accurate prediction of protein-peptide recognition multispecificity using self-consistent mean field theory , 2017, PLoS Comput. Biol..
[11] M. Eigen. Viral quasi species. , 1993 .
[12] David R. Liu,et al. A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations , 2014, Nature Communications.
[13] Michael T. Laub,et al. Pervasive degeneracy and epistasis in a protein-protein interface , 2015, Science.
[14] David L. Young,et al. High-throughput Analysis of in vivo Protein Stability* , 2013, Molecular & Cellular Proteomics.
[15] Rafael Sanjuán,et al. The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[16] E. Bornberg-Bauer,et al. Modeling evolutionary landscapes: mutational stability, topology, and superfunnels in sequence space. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[17] Eugene I Shakhnovich,et al. Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations. , 2017, Current opinion in structural biology.
[18] S. Wright. Evolution in mendelian populations , 1931 .
[19] M. DePristo,et al. Missense meanderings in sequence space: a biophysical view of protein evolution , 2005, Nature Reviews Genetics.
[20] S. Fields,et al. Deep mutational scanning: a new style of protein science , 2014, Nature Methods.
[21] Michael Manhart,et al. Protein folding and binding can emerge as evolutionary spandrels through structural coupling , 2014, Proceedings of the National Academy of Sciences.
[22] Hong Cao,et al. The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors , 2012, PLoS pathogens.
[23] A. Berger,et al. On the size of the active site in proteases. I. Papain. , 1967, Biochemical and biophysical research communications.
[24] C. Rice,et al. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies , 2013, Nature Medicine.
[25] A. Chakraborty,et al. Identification of drug resistance mutations in HIV from constraints on natural evolution. , 2015, Physical review. E.
[26] Dmitry Chudakov,et al. Local fitness landscape of the green fluorescent protein , 2016, Nature.
[27] Christopher J. Oldfield,et al. Do viral proteins possess unique biophysical features? , 2009, Trends in biochemical sciences.
[28] M. Ostermeier,et al. Environmental changes bridge evolutionary valleys , 2016, Science Advances.
[29] Matthew R. McKay,et al. Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies , 2018, Proceedings of the National Academy of Sciences.
[30] Sergey Brin,et al. The Anatomy of a Large-Scale Hypertextual Web Search Engine , 1998, Comput. Networks.
[31] L. Benatuil,et al. An improved yeast transformation method for the generation of very large human antibody libraries. , 2010, Protein engineering, design & selection : PEDS.
[32] H. Chan,et al. Biophysics of protein evolution and evolutionary protein biophysics , 2014, Journal of The Royal Society Interface.
[33] A. Lauring,et al. The Mutational Robustness of Influenza A Virus , 2016, PLoS pathogens.
[34] C. Wilke,et al. Biophysical models of protein evolution: Understanding the patterns of evolutionary sequence divergence , 2016, bioRxiv.
[35] R. Sanjuán,et al. Highly heterogeneous mutation rates in the hepatitis C virus genome , 2016, Nature Microbiology.
[36] F. J. Poelwijk,et al. The spatial architecture of protein function and adaptation , 2012, Nature.
[37] Amy E Keating,et al. Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1 , 2017, eLife.
[38] Michael J. Harms,et al. High-order epistasis shapes evolutionary trajectories , 2017, PLoS Comput. Biol..
[39] R. Andino,et al. Viral quasispecies. , 2015, Virology.
[40] John Maynard Smith,et al. Natural Selection and the Concept of a Protein Space , 1970, Nature.
[41] Raul Andino,et al. Mutational and fitness landscapes of an RNA virus revealed through population sequencing , 2013, Nature.
[42] Dan S. Tawfik,et al. Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature , 2016, Protein science : a publication of the Protein Society.
[43] Sagar D Khare,et al. Large‐scale Structure‐based Prediction and Identification of Novel Protease Substrates using Computational Protein Design , 2016, Journal of molecular biology.
[44] Timothy A. Whitehead,et al. Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded , 2017, Nature Communications.
[45] J. Marcotrigiano,et al. Viral precursor polyproteins: keys of regulation from replication to maturation , 2013, Current Opinion in Virology.
[46] Jian-Rong Yang,et al. Protein misinteraction avoidance causes highly expressed proteins to evolve slowly , 2012, Proceedings of the National Academy of Sciences.
[47] Raul Andino,et al. The role of mutational robustness in RNA virus evolution , 2013, Nature Reviews Microbiology.
[48] Christoph Adami,et al. Stability and the evolvability of function in a model protein. , 2004, Biophysical journal.
[49] D. Bolon,et al. Experimental illumination of a fitness landscape , 2011, Proceedings of the National Academy of Sciences.
[50] M. Jacomy,et al. ForceAtlas2, a Continuous Graph Layout Algorithm for Handy Network Visualization Designed for the Gephi Software , 2014, PloS one.
[51] A. Strongin,et al. New Details of HCV NS3/4A Proteinase Functionality Revealed by a High-Throughput Cleavage Assay , 2012, PloS one.
[52] Katherine Spindler,et al. Rapid evolution of RNA genomes. , 1982, Science.
[53] H J Alter,et al. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. , 2000, Science.
[54] Ralf Bartenschlager,et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus , 2005, Nature.
[55] Justin R Klesmith,et al. Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning , 2017, Proceedings of the National Academy of Sciences.
[56] Adrian W. R. Serohijos,et al. Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics. , 2014, Current opinion in structural biology.
[57] D. Baker,et al. High Resolution Mapping of Protein Sequence–Function Relationships , 2010, Nature Methods.
[58] G. Georgiou,et al. Profiling Protease Specificity: Combining Yeast ER Sequestration Screening (YESS) with Next Generation Sequencing. , 2017, ACS chemical biology.
[59] George Georgiou,et al. Engineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial libraries , 2013, Proceedings of the National Academy of Sciences.
[60] Timothy A. Whitehead,et al. High-Resolution Sequence-Function Mapping of Full-Length Proteins , 2015, PloS one.
[61] Feng Ding,et al. Emergence of Protein Fold Families through Rational Design , 2006, PLoS Comput. Biol..
[62] M. Huynen,et al. Neutral evolution of mutational robustness. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[63] Amy E Keating,et al. SORTCERY-A High-Throughput Method to Affinity Rank Peptide Ligands. , 2014, Journal of molecular biology.
[64] J. Krug,et al. Empirical fitness landscapes and the predictability of evolution , 2014, Nature Reviews Genetics.