Chondrosarcoma of the Larynx and Possibility of Conservative Surgery

Chondrosarcoma, a sub mucosal hard, slow growing and local aggressive tumor, is the most frequent mesenchymal neoplasm of the larynx. Diagnosis is supported both by clinical appearance and radiological evaluation, even because a biopsy is not always easy to obtain, due to its hardness. Laryngeal chondrosarcomas are histologically differentiated as low-, intermediateand high-grade lesions and total laryngectomy was considered the common treatment, even if nowadays, conservative open neck or endoscopic surgery, especially for low-grade lesions, is reported in several studies published in the literature. We discuss seven cases of laryngeal chondrosarcoma treated at our institution with different types of conservative surgery. The aim of this article is to assess the role of conservative treatments regarding the management of laryngeal chondrosarcomas, based upon personal experience and reviewing the literature data.

[1]  P. Nicolai,et al.  Transoral CO2 laser treatment for Tis–T3 glottic cancer: The University of Brescia experience on 595 patients , 2009, Head & neck.

[2]  J. Rodrigo,et al.  Surgical treatment of head and neck chondrosarcomas , 2010 .

[3]  M. Bullock,et al.  Chondrosarcoma of the head and neck: report of 11 cases and literature review. , 2009, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale.

[4]  A. Ostuni,et al.  Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. , 2009, Archives of otolaryngology--head & neck surgery.

[5]  M. Poupart,et al.  Cartilaginous tumors of the larynx: Endoscopic laser management using YAG/KTP , 2009, Head & neck.

[6]  A. Sparano,et al.  Chondrosarcoma of the Arytenoid Cartilage: A Case Report and Review of the Literature , 2007, Ear, nose, & throat journal.

[7]  K. Hörmann,et al.  Chondrosarcoma of the larynx and review of the literature. , 2007, Anticancer research.

[8]  M. Bellomi,et al.  Ultrasound‐guided transcutaneous Tru‐Cut biopsy to diagnose laryngopharyngeal masses , 2007, Cancer.

[9]  P. Ambrosch The role of laser microsurgery in the treatment of laryngeal cancer , 2007, Current opinion in otolaryngology & head and neck surgery.

[10]  L. Thompson Chondrosarcoma of the Larynx , 2004, Ear, nose, & throat journal.

[11]  H. Dere,et al.  Endolaryngeal resection of laryngeal chondrosarcoma , 2003, European Archives of Oto-Rhino-Laryngology.

[12]  L. Thompson,et al.  Chondrosarcoma of the Larynx: A Clinicopathologic Study of 111 Cases With a Review of the Literature , 2002, The American journal of surgical pathology.

[13]  L. Gilain,et al.  Laryngeal chondrosarcoma: a report of five cases , 2002, European Archives of Oto-Rhino-Laryngology.

[14]  Y. Rappaport,et al.  Chondrosarcoma of the Larynx: A Therapeutic Challenge , 2001, Ear, nose, & throat journal.

[15]  R. Thomé,et al.  Long-term follow-up of cartilaginous tumors of the larynx. , 2001, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[16]  R. Lufkin,et al.  Chondroid tumors of the larynx: computed tomography findings. , 1999, American journal of otolaryngology.

[17]  G. Snow,et al.  Long-term results of organ preservation in chondrosarcoma of the cricoid , 1999, European Archives of Oto-Rhino-Laryngology.

[18]  K. Olsen,et al.  Cartilaginous Tumors of the Larynx: Clinicopathologic Review of 47 Cases , 1997, The Annals of otology, rhinology, and laryngology.

[19]  H. Berg,et al.  Chondrosarcoma of the cricoid: the role of larynx preservation. , 1993, New Jersey medicine : the journal of the Medical Society of New Jersey.

[20]  A. Ferlito,et al.  Chondrosarcoma of the larynx: review of the literature and report of three cases. , 1984, American journal of otolaryngology.

[21]  R. Cantrell,et al.  Conservative Surgical Treatment of Chondrosarcoma of the Larynx , 1980, The Annals of otology, rhinology, and laryngology.

[22]  M. Romsdahl,et al.  Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading , 1977, Cancer.

[23]  M. Link Chondroma and chondrosarcoma of the larynx. , 1949, The Annals of otology, rhinology, and laryngology.

[24]  H. Jaffe,et al.  Chondrosarcoma of Bone. , 1943, The American journal of pathology.