Influenza Virology: Current Topics

each segment of the influenza genome to the virus’s overall activity. They note that, although the synthesis of viral RNA is well understood, less is known about genome replication (despite recent advances). Whittaker and Digard survey target cell entry and intracellular virus transport and highlight recent developments and differences between influenzaviruses. Important ion channels (such as M2) and potential new target sites for antiviral drugs are detailed by Lamb and Pinto. In their overview of influenzavirus interactions and methods for determining specificity (including a mention of sialyloligosaccharides with a2‐3 and a2‐6 receptors) and host range, Matrosovich et al. explain the differences between avian and human susceptibilities to the newer avian influenzavirus strains. Legge and Braciale describe induction and regulation of adaptive immune responses in dendritic cells following influenzavirus infection. La Gruta and Doherty present a qualitative and quantitative characterization of CD8 + T cells in immunity to influenza.