Restriction fragment length polymorphisms in dairy and beef cattle at the growth hormone and prolactin loci.

Two bovine populations, a Holstein-Friesian dairy stock and a synthetic (Baladi X Hereford X Simmental X Charolais) beef stock, were screened for restriction fragment length polymorphisms (RFLPs) at the growth hormone and prolactin genes. Most RFLPs at the growth hormone gene are apparently the consequence of an insertion/deletion event which was localized to a region downstream of the structural gene. The restriction map for the genomic region including the growth hormone gene was extended. Two HindIII RFLPs at the growth hormone locus, as well as several RFLPs at the prolactin gene, seemed to be the consequence of a series of point mutations. The results are discussed in terms of the possibility that minor genomic variability underlies quantitative genetic variation.

[1]  J. Beckmann,et al.  Restriction fragment length polymorphism among Israeli Holstein-Friesian dairy bulls. , 1986, Animal genetics.

[2]  D. Robertson A possible technique for isolating genic DNA for quantitative traits in plants , 1985 .

[3]  D. Bauman,et al.  Responses of high-producing dairy cows to long-term treatment with pituitary somatotropin and recombinant somatotropin. , 1985, Journal of dairy science.

[4]  D. Moore,et al.  The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[5]  R. Pearson,et al.  Influence of selection for milk yield on endogenous hormones and metabolites in Holstein heifers and cows. , 1985, Journal of animal science.

[6]  S. Camper,et al.  Characterization of the bovine prolactin gene. , 1984, DNA.

[7]  J. Donelson,et al.  Nucleotide sequence of the bovine growth hormone chromosomal gene , 1983, Molecular and Cellular Endocrinology.

[8]  H. Cann,et al.  Polymorphic restriction endonuclease fragment segregates and correlates with the gene for HLA-B8. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[9]  N. Birnberg,et al.  Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[10]  S. Camper,et al.  Cloning and nucleotide sequencing of the bovine growth hormone gene. , 1982, Nucleic acids research.

[11]  W. Miller Bovine prolactin: corrected cDNA sequence and genetic polymorphisms. , 1982, DNA.

[12]  J. Martial,et al.  Hormonal regulation of growth hormone mRNA. , 1982, DNA.

[13]  J. Shine,et al.  Primary structure and evolution of rat growth hormone gene. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Bauman,et al.  Prolactin regulation of milk secretion and biochemical differentiation of mammary epithelial cells in periparturient cows. , 1981, Endocrinology.

[15]  E. Kawasaki,et al.  Thyroid or glucocorticoid hormone induces pre-growth-hormone mRNA and its probable nuclear precursor in rat pituitary cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[16]  E. Keshet,et al.  Cloning of bovine growth hormone gene and its expression in bacteria , 1981, Nucleic Acids Res..

[17]  R. White,et al.  A highly polymorphic locus in human DNA. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Martial,et al.  Molecular cloning of DNA complementary to bovine growth hormone mRNA. , 1980, The Journal of biological chemistry.

[19]  E. Thompson,et al.  Genomic organization of rat prolactin and growth hormone genes. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[20]  P. Seeburg,et al.  Regulation of growth hormone messenger RNA. , 1979, Monographs on endocrinology.

[21]  L. Phillips,et al.  The regulation of growth by endocrines. , 1975, Annual review of physiology.

[22]  R. Sauer,et al.  Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[23]  A. Rogol,et al.  Structural studies on bovine growth hormone. I. Isolation and characterization of cyanogen bromide fragments. , 1969, The Journal of biological chemistry.