Inflammatory Responses in Rheumatoid Arthritis NETs Are a Source of Citrullinated Autoantigens and Stimulate

altered NETosis in rheumatoid arthritis patients may contribute to the pathogenesis of disease. citrullinated proteins, and these NETs enhanced the inflammatory response in fibroblasts from inflamed joints. Thus, altered the makeup of the proteins secreted by neutrophils. NETs from rheumatoid arthritis patients contained patients with non-autoimmune osteoarthritis. Indeed, NETosis correlated with levels of ACPA, and ACPA actually authors observed increased NETosis in patients with rheumatoid arthritis compared with both healthy controls and Autoantibodies to citrullinated antigens (ACPAs) are thought to be pathogenic in rheumatoid arthritis. The . look at the role of NETosis in rheumatoid arthritis. et al autoimmune response. Now, Khandpur neutrophil response to bacteria, but the secretion of self-antigens in the context of inflammatory stimuli may boost externalized is through the excretion of neutrophil extracellular traps (NETosis). NETosis is thought to be involved in be normally intracellular proteins are exposed to the immune response. One hypothesis as to how these proteins may have been identified, although it remains unclear how these −− cellular targets of the immune response −− autoantigens protect. Yet, what exactly induces this loss of tolerance to self remains murky. For some autoimmune diseases, Autoimmune diseases are caused when the body's immune system attacks the very tissues it's supposed to Autoantigens Slip Through the NET

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