Unraveling Immune Privilege

J. W. Streilein discusses the concept of immune privilege, which protects from rejection tissues grafted to certain sites in the body. The differences between immune-privileged sites and immune-privileged tissues are illustrated by two recent papers implicating the cell surface protein FasL in immune privilege in the eye (Science, p. 1189 of this issue) and in the testis [D. Bellgrau et al., Nature 377, 630 (1995)].

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