Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry

[1]  M. Tosetti,et al.  MR imaging of the substantia nigra at 7 T enables diagnosis of Parkinson disease. , 2014, Radiology.

[2]  Arno Villringer,et al.  Open Science CBS Neuroimaging Repository: Sharing ultra-high-field MR images of the brain , 2016, NeuroImage.

[3]  Cyril Poupon,et al.  7 tesla magnetic resonance imaging: A closer look at substantia nigra anatomy in Parkinson's disease , 2014, Movement disorders : official journal of the Movement Disorder Society.

[4]  Nikolaus Weiskopf,et al.  In-vivo magnetic resonance imaging (MRI) of laminae in the human cortex , 2017, NeuroImage.

[5]  A. Roch,et al.  Anomalous nuclear magnetic relaxation of aqueous solutions of ferritin: An unprecedented first‐order mechanism , 2002, Magnetic resonance in medicine.

[6]  M. Herrero,et al.  Multiple mechanisms of neurodegeneration and progression , 2017, Progress in Neurobiology.

[7]  Josephine M. Groot,et al.  7 Tesla MRI Followed by Histological 3D Reconstructions in Whole-Brain Specimens , 2019, Frontiers in Neuroanatomy.

[8]  M. Barcikowska,et al.  Iron in parkinsonian and control substantia nigra—A mössbauer spectroscopy study , 1996, Movement disorders : official journal of the Movement Disorder Society.

[9]  Karla L. Miller,et al.  Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques , 2012, NeuroImage.

[10]  J M Taveras,et al.  Magnetic Resonance in Medicine , 1991, The Western journal of medicine.

[11]  C D Marsden,et al.  Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. , 1991, Brain : a journal of neurology.

[12]  Oliver Speck,et al.  Erratum: T1-weighted in vivo human whole brain MRI dataset with an ultrahigh isotropic resolution of 250 μm , 2017, Scientific Data.

[13]  Yves Agid,et al.  Parkinson's disease: pathophysiology , 1991, The Lancet.

[14]  S. Fahn,et al.  Study of movement disorders and brain iron by MR. , 1987, AJR. American journal of roentgenology.

[15]  E. Schäfer-Nolte Development of a diamond-based scanning probe spin sensor operating at low temperature in ultra high vacuum , 2014 .

[16]  Arno Klein,et al.  A reproducible evaluation of ANTs similarity metric performance in brain image registration , 2011, NeuroImage.

[17]  Ferdinand Schweser,et al.  Quantitative Susceptibility Mapping in Parkinson's Disease , 2016, PloS one.

[18]  V. Kiselev,et al.  Transverse NMR relaxation in magnetically heterogeneous media. , 2008, Journal of magnetic resonance.

[19]  Peter Riederer,et al.  Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains , 1989, Journal of neurochemistry.

[20]  Dmitry S. Novikov,et al.  Transverse NMR relaxation in biological tissues , 2018, NeuroImage.

[21]  Andrew G. Webb,et al.  Origin and reduction of motion and f0 artifacts in high resolution T2*-weighted magnetic resonance imaging: Application in Alzheimer's disease patients , 2010, NeuroImage.

[22]  R. Bowtell,et al.  Visualization of nigrosome 1 and its loss in PD , 2013, Neurology.

[23]  C. Marsden,et al.  Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease , 1989, Journal of neurochemistry.

[24]  Qing X Yang,et al.  The effect of iron in MRI and transverse relaxation of amyloid‐beta plaques in Alzheimer's disease , 2015, NMR in biomedicine.

[25]  Robert Turner,et al.  Myelin and iron concentration in the human brain: A quantitative study of MRI contrast , 2014, NeuroImage.

[26]  C. Ryan PIXE and the nuclear microprobe: Tools for quantitative imaging of complex natural materials , 2011 .

[27]  Dmitriy A Yablonskiy,et al.  Separation of cellular and BOLD contributions to T2* signal relaxation , 2016, Magnetic resonance in medicine.

[28]  A. Haase,et al.  FLASH imaging: rapid NMR imaging using low flip-angle pulses. 1986. , 1986, Journal of magnetic resonance.

[29]  Klaus Seppi,et al.  Visualization of nigrosome 1 and its loss in PD: Pathoanatomical correlation and in vivo 7T MRI , 2014, Neurology.

[30]  E. Haacke,et al.  Imaging iron stores in the brain using magnetic resonance imaging. , 2005, Magnetic resonance imaging.

[31]  F. Reinhard,et al.  A diamond-based scanning probe spin sensor operating at low temperature in ultra-high vacuum. , 2014, The Review of scientific instruments.

[32]  A. Roch,et al.  Relaxation induced by ferritin and ferritin‐like magnetic particles: The role of proton exchange , 2000, Magnetic resonance in medicine.

[33]  Oliver Speck,et al.  Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases , 2019, Brain : a journal of neurology.

[34]  Se Young Chun,et al.  Specific visualization of neuromelanin-iron complex and ferric iron in the human post-mortem substantia nigra using MR relaxometry at 7T , 2017, NeuroImage.

[35]  Nikolaus Weiskopf,et al.  Microstructural imaging of human neocortex in vivo , 2018, NeuroImage.

[36]  C. Zhong,et al.  Combined Visualization of Nigrosome-1 and Neuromelanin in the Substantia Nigra Using 3T MRI for the Differential Diagnosis of Essential Tremor and de novo Parkinson's Disease , 2019, Front. Neurol..

[37]  Eung Yeop Kim,et al.  Nigrosome 1 imaging: technical considerations and clinical applications. , 2019, The British journal of radiology.

[38]  Sergio Cerutti,et al.  Contrast mechanisms associated with neuromelanin‐MRI , 2017, Magnetic resonance in medicine.

[39]  Z. Cho,et al.  Seven‐tesla magnetic resonance images of the substantia nigra in Parkinson disease , 2012, Annals of neurology.

[40]  Luis Ibáñez,et al.  The Design of SimpleITK , 2013, Front. Neuroinform..

[41]  Yan Li,et al.  Imaging the Nigrosome 1 in the substantia nigra using susceptibility weighted imaging and quantitative susceptibility mapping: An application to Parkinson's disease , 2019, NeuroImage: Clinical.

[42]  Jeff H Duyn,et al.  The role of iron in brain ageing and neurodegenerative disorders , 2014, The Lancet Neurology.

[43]  Or Kakhlon,et al.  The labile iron pool: characterization, measurement, and participation in cellular processes(1). , 2002, Free radical biology & medicine.

[44]  J. Schenck,et al.  Health and Physiological Effects of Human Exposure to Whole‐Body Four‐Tesla Magnetic Fields during MRI , 1992, Annals of the New York Academy of Sciences.

[45]  A. Graybiel,et al.  The substantia nigra of the human brain. I. Nigrosomes and the nigral matrix, a compartmental organization based on calbindin D(28K) immunohistochemistry. , 1999, Brain : a journal of neurology.

[46]  J. Connor,et al.  Transferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions , 1995, Journal of neurochemistry.

[47]  A. Stefani,et al.  Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature. , 2010, Brain : a journal of neurology.

[48]  R. Bowtell,et al.  Fiber orientation-dependent white matter contrast in gradient echo MRI , 2012, Proceedings of the National Academy of Sciences.

[49]  Marcus E. Raichle,et al.  Genetically defined cellular correlates of the baseline brain MRI signal , 2018, Proceedings of the National Academy of Sciences.

[50]  Tobias Kober,et al.  Simultaneous Quantitative MRI Mapping of T1, T2* and Magnetic Susceptibility with Multi-Echo MP2RAGE , 2017, PloS one.

[51]  Houeto Jean-Luc [Parkinson's disease]. , 2022, La Revue du praticien.

[52]  H. Sebastian Seung,et al.  Trainable Weka Segmentation: a machine learning tool for microscopy pixel classification , 2017, Bioinform..

[53]  M. Fukunaga,et al.  Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast , 2010, Proceedings of the National Academy of Sciences.

[54]  Alberto Gatti,et al.  The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[55]  T. Reinert,et al.  Ion exchanger in the brain: Quantitative analysis of perineuronally fixed anionic binding sites suggests diffusion barriers with ion sorting properties , 2015, Scientific Reports.

[56]  Robert Turner,et al.  Toward in vivo histology: A comparison of quantitative susceptibility mapping (QSM) with magnitude-, phase-, and R2 ⁎-imaging at ultra-high magnetic field strength , 2013, NeuroImage.

[57]  Minh Phuong Nguyen,et al.  The Neuromelanin-related T2* Contrast in Postmortem Human Substantia Nigra with 7T MRI , 2016, Scientific Reports.

[58]  V. Kiselev,et al.  Transverse NMR relaxation as a probe of mesoscopic structure. , 2002, Physical review letters.

[59]  Yasuo Terayama,et al.  Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease , 2006, Neuroreport.

[60]  W. Poewe,et al.  Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease , 2017, Movement disorders : official journal of the Movement Disorder Society.

[61]  P. Calabresi,et al.  T2*-weighted MRI values correlate with motor and cognitive dysfunction in Parkinson's disease , 2019, Neurobiology of Aging.

[62]  Stanley Fahn,et al.  Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson’s disease , 2018, npj Parkinson's Disease.

[63]  T. Reinert,et al.  Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease , 2021, Acta Neuropathologica Communications.

[64]  Nikolaus Weiskopf,et al.  Quantitative multi-parameter mapping of R1, PD*, MT, and R2* at 3T: a multi-center validation , 2013, Front. Neurosci..

[65]  B. Hallgren,et al.  THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN , 1958, Journal of neurochemistry.

[66]  Fabian J. Theis,et al.  fastER: a user‐friendly tool for ultrafast and robust cell segmentation in large‐scale microscopy , 2017, Bioinform..

[67]  Tilman Butz,et al.  Determination of trace elements in the human substantia nigra , 2005 .

[68]  Christian Langkammer,et al.  Effects of formalin fixation and temperature on MR relaxation times in the human brain , 2016, NMR in biomedicine.

[69]  E. Haacke,et al.  Theory of NMR signal behavior in magnetically inhomogeneous tissues: The static dephasing regime , 1994, Magnetic resonance in medicine.

[70]  R A Brooks,et al.  Relaxometry and magnetometry of ferritin , 1998, Magnetic resonance in medicine.

[71]  Oliver Speck,et al.  Highest Resolution In Vivo Human Brain MRI Using Prospective Motion Correction , 2015, PloS one.

[72]  Anna Devor,et al.  Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe , 2015, The Journal of Neuroscience.

[73]  Jeff H. Duyn,et al.  Susceptibility contrast in high field MRI of human brain as a function of tissue iron content , 2009, NeuroImage.

[74]  Y. Agid,et al.  Does neuromelanin contribute to the vulnerability of catecholaminergic neurons in monkeys intoxicated with MPTP? , 1993, Neuroscience.

[75]  M. Décorps,et al.  Vessel size imaging , 2001, Magnetic resonance in medicine.

[76]  Y. Shibamoto,et al.  Visualization of Nigrosome 1 from the Viewpoint of Anatomic Structure , 2019, American Journal of Neuroradiology.

[77]  Dorothee P. Auer,et al.  The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T , 2014, PloS one.

[78]  T. Reinert,et al.  Quantitative trace element analysis with sub-micron lateral resolution , 2006 .

[79]  B. J. Kim,et al.  Comparison of the magnetic properties of natural ferritin with those of aggregated magnetic core of ferritin , 2004 .

[80]  Jeff H Duyn,et al.  Contributions to magnetic susceptibility of brain tissue , 2017, NMR in biomedicine.

[81]  W Craelius,et al.  Iron deposits surrounding multiple sclerosis plaques. , 1982, Archives of pathology & laboratory medicine.

[82]  Tadeusz Sarna,et al.  Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease , 2017, Progress in Neurobiology.

[83]  J. Connor,et al.  Iron, brain ageing and neurodegenerative disorders , 2004, Nature Reviews Neuroscience.

[84]  C Strand,et al.  9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease , 2016, NeuroImage: Clinical.

[85]  Kamil Ugurbil,et al.  An integrative model for neuronal activity-induced signal changes for gradient and spin echo functional imaging , 2009, NeuroImage.

[86]  R. Bowtell,et al.  Application of a Fourier‐based method for rapid calculation of field inhomogeneity due to spatial variation of magnetic susceptibility , 2005 .

[87]  D. Auer,et al.  Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI , 2018, NeuroImage: Clinical.

[88]  Ferdinand Schweser,et al.  Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study , 2012, NeuroImage.

[89]  S. Johanna Vannesjo,et al.  Retrospective correction of physiological field fluctuations in high‐field brain MRI using concurrent field monitoring , 2015, Magnetic resonance in medicine.

[90]  T. Reinert,et al.  High resolution quantitative element mapping of neuromelanin-containing neurons , 2007 .

[91]  Hansol Lee,et al.  MRI T2 and T2* relaxometry to visualize neuromelanin in the dorsal substantia nigra pars compacta , 2020, NeuroImage.

[92]  A. Graybiel,et al.  The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. , 1999, Brain : a journal of neurology.