Evaluation of a collagen-based biosynthetic material for the repair of abdominal wall defects.

A collagen tissue polymer composite manufactured in sheep and prepared in two different forms (wet and dry) was compared to polypropylene mesh and to a control group for effectiveness in the repair of an abdominal wall defect in a rabbit model. The wet and dry patches were shown to differ significantly in their pore size. The wet material was shown to retain its natural porosity and promoted neovascularization, tissue integration, cellular infiltration, and neomatrix formation compared to the dry collagen-polymer patch. This material was superior to the polypropylene mesh implant, which was associated with significant adhesions. The appearance of type VI collagen was the earliest sign of new cell infiltration and neomatrix formation within the implant. New deposition of type VI collagen was apparent throughout the thickness of the implant within 4 weeks, followed by type III collagen accumulation. Decreased porosity of the collagen component in the dry patches resulted in a totally nonintegrated implant. This induced a foreign-body capsule with minimal cellular tissue infiltration and no deposition of collagen types VI and III within the implant.

[1]  G. Edwards,et al.  Early performance appraisal of the Omniflow II Vascular Prosthesis as an indicator of long-term function. , 1995, Journal of long-term effects of medical implants.

[2]  J. Werkmeister,et al.  Evaluation of alternative glutaraldehyde stabilization strategies for collagenous biomaterials , 1994 .

[3]  R. Bleichrodt,et al.  Reherniation after repair of the abdominal wall with expanded polytetrafluoroethylene. , 1994, Journal of the American College of Surgeons.

[4]  I. Lichtenstein,et al.  Experimental evaluation of a new composite mesh with the selective property of incorporation to the abdominal wall without adhering to the intestines. , 1994, Journal of biomedical materials research.

[5]  J. Werkmeister,et al.  Evaluation of the Omniflow collagen-polymer vascular prosthesis. , 1994, Medical Progress Through Technology.

[6]  J. Werkmeister,et al.  Monoclonal antibodies to type VI collagen demonstrate new tissue augmentation of a collagen-based biomaterial implant. , 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[7]  J. Naim,et al.  Reduction of postoperative adhesions to Marlex mesh using experimental adhesion barriers in rats. , 1993, Journal of laparoendoscopic surgery.

[8]  G. Edwards,et al.  Structural analysis of a collagen--polyester composite vascular prosthesis. , 1993, Clinical Materials.

[9]  H. Sevestre,et al.  [Treatment of postoperative incisional hernias by a composite prosthesis (polyester-polyglactin 910). Clinical and experimental study]. , 1993, Annales de chirurgie.

[10]  R. Bleichrodt,et al.  Expanded polytetrafluoroethylene patch versus polypropylene mesh for the repair of contaminated defects of the abdominal wall. , 1993, Surgery, gynecology & obstetrics.

[11]  J. Werkmeister,et al.  Multiple antigenic determinants on type III collagen. , 1991, The Biochemical journal.

[12]  G. Edwards,et al.  Structural stability of long-term implants of a collagen-based vascular prosthesis. , 1991, Journal of long-term effects of medical implants.

[13]  J. Werkmeister,et al.  Development of monoclonal antibodies to collagens for assessing host-implant interactions. , 1989, Journal of biomedical materials research.

[14]  J. Werkmeister,et al.  Collagen organization in mandrel-grown vascular grafts. , 1989, Journal of biomedical materials research.

[15]  H. Ellis,et al.  Adhesion formation and peritoneal healing on prosthetic materials , 1988 .

[16]  F. Silver,et al.  Collagen-based wound dressings: control of the pore structure and morphology. , 1986, Journal of biomedical materials research.

[17]  D. Kaminski,et al.  Comparative evaluation of synthetic meshes used for abdominal wall replacement. , 1983, Surgery.

[18]  Z. Kaufman,et al.  Fecal fistula: A late complication of Marlex® mesh repair , 1981, Diseases of the colon and rectum.

[19]  T. Fabian,et al.  Management of Acute Full‐thickness Losses of the Abdominal Wall , 1981, Annals of surgery.

[20]  B. Christie,et al.  Glutaraldehyde-tanned ovine collagen conduits as vascular xenografts in dogs: a preliminary report. , 1980, Archives of surgery.

[21]  I. Yannas,et al.  Design of an artificial skin. I. Basic design principles. , 1980, Journal of biomedical materials research.

[22]  A. M. Granda,et al.  Marlex mesh in repair of a diaphragmatic defect later eroding into the distal esophagus and stomach. , 1979, The American surgeon.

[23]  G. Larson,et al.  Plastic mesh repair of incisional hernias. , 1978, American journal of surgery.

[24]  B. Rigby,et al.  Oxygen participation in the in vivo and in vitro aging of collagen fibres. , 1977, Biochemical and biophysical research communications.

[25]  Boyd Wc.  Use of Marlex mesh in acute loss of the abdominal wall due to infection. , 1977 .

[26]  Usher Fc.  The repair of incisional and inguinal hernias. , 1970 .