A Simulation Model for Intracranial Fluid Dynamics

Abstract Most parameters inside the human body are regulated with biological control systems in order to maintain an optimal environment for the body cells. This paper aims at the development of models which interpret these control loops in a technical manner so they may be used in a technical simulation environment. As an example, a model for intracranial fluid dynamics is presented. Starting from first order principles (like conservation of mass, …) and constitutive equations models for the liquor circulation system and the autoregulation of cerebral blood flow are derived and implemented in a simulation environment under Matlab/Simulink. The simulation may be used for educational purposes or the development of new treatment and diagnostic strategies.