Development of a miniature gamma-ray endoscopic probe for tumor localization in nuclear medicine

Two types of miniature gamma-ray endoscopic probes developed for insertion into a body cavity to detect invisibly small or deeply located tumors are described. One is a single detector system using a small BGO (Bi/sub 4/Ge/sub 3/O/sub 12/) crystal connected with a fiber optic light guide, and the other is a dual detector system using a pair of single detector probes of the same size combined with a random coincidence technique. The performance of these detectors was tested by using a point source and a hollow cylindrical water phantom that simulated a body cavity. Measured and calculated results indicated that a dual detector system can be used for realistic tumor localization in a body cavity, and a single detector system may be applied only for the detection of tumors in which radiopharmaceuticals that emit gamma rays of energy below about 200 keV are accumulated. >

[1]  E. Martin,et al.  Intraoperative radioimmunodetection of colorectal tumor with a hand-held radiation detector. , 1985, American journal of surgery.

[2]  H. B. Barber,et al.  Lung cancer detection using a miniature sodium iodide detector and cobalt-57 bleomycin. , 1984, Chest.

[3]  J G Hardy,et al.  Evaluation of a sterilizable radiation probe as an aid to the surgical treatment of osteoid-osteoma. Technical note. , 1983, The Journal of bone and joint surgery. American volume.

[4]  H. B. Barber,et al.  Small Radiation Detectors for Bronchoscopic Tumor Localization , 1980, IEEE Transactions on Nuclear Science.

[5]  E. Martin,et al.  A gamma-detecting probe for radioimmune detection of CEA-producing tumors , 1984, Diseases of the colon and rectum.

[6]  J. Lancaster,et al.  Technical anc clinical characteristics of a surgical biopsy probe. , 1981, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[7]  Harrison H. Barrett,et al.  Probes Containing Gamma Radiation Detectors For In Vivo Tumor Detection And Imaging , 1989, Photonics West - Lasers and Applications in Science and Engineering.

[8]  J. Hardy,et al.  Mediastinal parathyroid adenoma: A new method of localization , 1984, The British journal of surgery.

[9]  N P Lang,et al.  Precise intraoperative location of gastrointestinal bleeding with a hand-held counter. Work in progress. , 1986, Radiology.

[10]  H H Barrett,et al.  Dual-detector probe for surgical tumor staging. , 1988, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  K. L. Swinth,et al.  Biomedical probe using a fiber-optic coupled scintillator. , 1976, Medical physics.

[12]  H. B. Barber,et al.  Radiation detector probes for tumor localization using tumor-seeking radioactive tracers. , 1989, AJR. American journal of roentgenology.