Successfully Surgical Treatment of Lung Metastatic Hepatoblastoma: A Rare Case Report

Background Hepatoblastoma is a common liver malignancy in children and commonly presents with primary tumors. In hepatoblastoma, lung is the most common place to metastasis. Chemotherapy have led to many improvements in the local control of hepatoblastoma. A main goal of treatment for hepatoblastoma is to achieve complete tumor resection. Case Presentation The patient was a 2.5 years old boy with abdominal distention and abdominal pain. Abdominal and pelvic ultrasound and thoracic and abdominal CT was performed for the patient and the results of them showed a large and hyperecho mass in the liver and several nodular lesions in lung segments. After doing some other tests, the diagnosis for the patient was hepatoblastoma. After chemothetapy the primary tumor was removed by surgery. Follow-up by CT scan after second chemotherapy showed that the lesions in the liver were removed, but lung masses were still unchanged and after second surgery, lung masses were removed too. The outcome has been favorable with no recurrence as of 20 months after the operation. Conclusion In our case, the patient did not respond to chemotherapy and as main treatment, surgery was carried out, that shows its importance in the treatment of hepatoblastoma.

[1]  Yang Li,et al.  Multidisciplinary effort in treating children with hepatoblastoma in China. , 2016, Cancer letters.

[2]  G. Tiao,et al.  Relapsed hepatoblastoma confined to the lung is effectively treated with pulmonary metastasectomy. , 2016, Journal of pediatric surgery.

[3]  M. Wijnen,et al.  Surgical treatment of childhood hepatoblastoma in the Netherlands (1990–2013) , 2016, Pediatric Surgery International.

[4]  J. Karpelowsky,et al.  Outcomes of pulmonary metastases in hepatoblastoma--is the prognosis always poor? , 2013, Journal of pediatric surgery.

[5]  C. Iancu,et al.  Mixed hepatoblastoma in child. Case report. , 2010, Medical ultrasonography.

[6]  G. Perilongo,et al.  Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  H. Katzenstein,et al.  Surgical resection of pulmonary metastatic lesions in children with hepatoblastoma. , 2007, Journal of pediatric surgery.

[8]  M. Stringer,et al.  Outcome and complications after resection of hepatoblastoma. , 2004, Journal of pediatric surgery.

[9]  H. Mugishima,et al.  Analysis of treatment outcome for children with recurrent or metastatic hepatoblastoma , 2003, Pediatric Surgery International.

[10]  B. Moreland,et al.  Pulmonary metastasectomy for pediatric solid tumors , 2004, Pediatric Surgery International.

[11]  E. Hiyama,et al.  High‐dose chemotherapy in children with metastatic hepatoblastoma , 2002, Pediatrics international : official journal of the Japan Pediatric Society.

[12]  M. Şenocak,et al.  Pulmonary Metastases in Children: An Analysis of Surgical Spectrum , 2002, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

[13]  G. Perilongo,et al.  Surgical view of the treatment of patients with hepatoblastoma , 2002, Cancer.

[14]  G. Perilongo,et al.  Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: a successful approach--results of the first prospective study of the International Society of Pediatric Oncology. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  G. Perilongo,et al.  Hepatoblastoma presenting with lung metastases , 2000, Cancer.

[16]  J. Quinn,et al.  Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  G. Perilongo,et al.  Pretreatment prognostic factors for children with hepatoblastoma-- results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1. , 2000, European journal of cancer.

[18]  A. Olshan,et al.  Hormone and fertility drug use and the risk of neuroblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. , 1999, American journal of epidemiology.

[19]  D. V. von Schweinitz,et al.  Analysis of treatment efficiency of carboplatin and etoposide in combination with radical surgery in advanced and recurrent childhood hepatoblastoma: A report of the German Cooperative Pediatric Liver Tumor Study HB 89 and HB 94 , 1999, Klinische Padiatrie.

[20]  R. Andrassy,et al.  Aggressive excision of pulmonary metastases is warranted in the management of childhood hepatic tumors. , 1991, Journal of pediatric surgery.

[21]  M. Dasouki,et al.  Trisomy 18 and hepatic neoplasia. , 1987, American journal of medical genetics.

[22]  J. Orgaz [Hepatic tumors]. , 1952, Revista medica de Cordoba.