Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
暂无分享,去创建一个
S. Benzer | P. Kapahi | V. Sapin | B. Zid | Brian M. Zid | P. Kapahi | B. M. Zid | T. Harper | D. Koslover | V. Sapin | S. Benzer | T. Harper | D. Koslover | Tony Harper | Daniel J. Koslover
[1] Matthias Blüher,et al. Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue , 2003, Science.
[2] E. Hafen,et al. The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth. , 1996, The EMBO journal.
[3] E. Hafen,et al. Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein , 2001, Science.
[4] C. Kenyon,et al. Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan , 2003, Cell.
[5] Xinsheng Gao,et al. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. , 2001, Genes & development.
[6] J. Montagne,et al. A Nutrient Sensor Mechanism Controls Drosophila Growth , 2003, Cell.
[7] A. Force,et al. Factors contributing to the plasticity of the extended longevity phenotypes of Drosophila , 1996, Experimental Gerontology.
[8] T. Kirkwood,et al. Mechanisms and Evolution of Aging , 1996, Science.
[9] O. Hino,et al. Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling , 2002, Nature Cell Biology.
[10] M. Tatar,et al. A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function , 2001, Science.
[11] E. Hafen,et al. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. , 2003, Trends in cell biology.
[12] D. Riddle,et al. Interacting genes in nematode dauer larva formation , 1981, Nature.
[13] E. Hafen,et al. Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4 , 1999, Cell.
[14] Koutarou D. Kimura,et al. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. , 2000, Science.
[15] Tibor Vellai,et al. Genetics: Influence of TOR kinase on lifespan in C. elegans , 2003, Nature.
[16] M. Klass,et al. Non-ageing developmental variant of Caenorhabditis elegans , 1976, Nature.
[17] T. P. Neufeld,et al. Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila , 2002, Genesis.
[18] J. Heitman,et al. Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. , 1999, Molecular biology of the cell.
[19] B. Dickson,et al. The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation , 2001, Cell.
[20] Blanka Rogina,et al. Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction , 2002, Science.
[21] R Holliday,et al. Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation? , 1989, BioEssays : news and reviews in molecular, cellular and developmental biology.
[22] S. Austad,et al. Genetic analysis of ageing: role of oxidative damage and environmental stresses , 1996, Nature Genetics.
[23] D. Berrigan,et al. Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. , 2003, Annual review of medicine.
[24] Steven J. Marygold,et al. Growth Signaling: TSC Takes Its Place , 2002, Current Biology.
[25] G. Ooi,et al. The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system. , 2001, The Journal of endocrinology.
[26] G. Rubin,et al. gigas , a Drosophila Homolog of Tuberous Sclerosis Gene Product-2, Regulates the Cell Cycle , 1999, Cell.
[27] J. Thomas,et al. Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. , 1992, Genetics.
[28] P. Kapahi,et al. Evolution, stress, and longevity , 2000, Journal of anatomy.
[29] C. Kenyon,et al. A C. elegans mutant that lives twice as long as wild type , 1993, Nature.
[30] L. Guarente,et al. Genetic pathways that regulate ageing in model organisms , 2000, Nature.
[31] G. Thomas. The S6 kinase signaling pathway in the control of development and growth. , 2002, Biological research.
[32] C. Potter,et al. Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size , 2001, Cell.
[33] A. Bürkle. Mechanisms of ageing , 2001, Eye.
[34] M. Rose,et al. The effects of nutritional manipulation and laboratory selection on lifespan in Drosophila melanogaster. , 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.
[35] J. S. Britton,et al. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. , 2002, Developmental Cell.
[36] E. Hafen,et al. Dietary Restriction in Long-Lived Dwarf Flies , 2002, Science.
[37] S. Melov,et al. Extension of life-span with superoxide dismutase/catalase mimetics. , 2000, Science.
[38] E. Hafen,et al. Drosophila S6 kinase: a regulator of cell size. , 1999, Science.
[39] Hélène Barcelo,et al. Altering Drosophila S6 kinase activity is consistent with a role for S6 kinase in growth , 2002, Genesis.
[40] G. Thomas,et al. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. , 2002, Genes & development.
[41] Linda Partridge,et al. Mechanisms of ageing: public or private? , 2002, Nature reviews. Genetics.
[42] Piotr Mikolajczyk,et al. A+A+C , 1964 .
[43] M. Tatar,et al. The Endocrine Regulation of Aging by Insulin-like Signals , 2003, Science.
[44] R. Weindruch. Effect of caloric restriction on age-associated cancers , 1992, Experimental Gerontology.
[45] S. Benzer,et al. Spatio‐temporal analysis of gene expression during aging in Drosophila melanogaster , 2002, Aging cell.
[46] E. Hafen,et al. The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling , 2003, Journal of biology.
[47] Linda Partridge,et al. Mechanisms of aging: public or private? , 2002, Nature Reviews Genetics.