Detection of ultrasound-modulated diffuse photons using spectral-hole burning.

The lack of efficient detection techniques has so far prevented ultrasound-modulated optical tomography from achieving maturity. By applying a quantum spectral filter based on spectral-hole burning, one modulation sideband of the ultrasound-modulated diffuse photons can be efficiently selected while the DC and the other sidebands are blocked. This technique features a large etendue as well as the capability of processing numerous speckles in parallel. It is also immune to speckle decorrelation, potentially allowing real-time in vivo imaging. Both theory and experiments are presented.

[1]  T. Mossberg,et al.  Time-domain frequency-selective optical data storage. , 1982, Optics letters.

[2]  A. Boccara,et al.  Ultrasonic tagging of photon paths in scattering media: parallel speckle modulation processing. , 1999, Optics letters.

[3]  G. Duclos New York 1987 , 2000 .

[4]  Eric L. Miller,et al.  Imaging the body with diffuse optical tomography , 2001, IEEE Signal Process. Mag..

[5]  Murray Sargent,et al.  Elements of Quantum Optics , 1991 .

[6]  G Roosen,et al.  Photorefractive detection of tagged photons in ultrasound modulated optical tomography of thick biological tissues. , 2004, Optics express.

[7]  S L Jacques,et al.  Continuous-wave ultrasonic modulation of scattered laser light to image objects in turbid media. , 1995, Optics letters.

[8]  Charles A DiMarzio,et al.  Imaging in diffuse media with pulsed-ultrasound-modulated light and the photorefractive effect. , 2005, Applied optics.

[9]  A. Boccara,et al.  Pulsed acousto-optic imaging in dynamic scattering media with heterodyne parallel speckle detection. , 2005, Optics letters.

[10]  G Roosen,et al.  Theoretical description of the photorefractive detection of the ultrasound modulated photons in scattering media. , 2005, Optics express.

[11]  Daniel Dolfi,et al.  Demonstration of a radio-frequency spectrum analyzer based on spectral hole burning , 2001 .

[12]  Monson H. Hayes,et al.  Statistical Digital Signal Processing and Modeling , 1996 .

[13]  L V Wang,et al.  Mechanisms of ultrasonic modulation of multiply scattered coherent light: a Monte Carlo model. , 2001, Optics letters.

[14]  L V Wang,et al.  Frequency-swept ultrasound-modulated optical tomography of scattering media. , 1998, Optics letters.

[15]  J. Eberly,et al.  Optical resonance and two-level atoms , 1975 .

[16]  Youzhi Li,et al.  Pulsed ultrasound-modulated optical tomography using spectral-hole burning as a narrowband spectral filter. , 2008, Applied physics letters.

[17]  P C Hobbs,et al.  Ultrasensitive laser measurements without tears. , 1997, Applied optics.

[18]  B G Sfez,et al.  Pulsed ultrasound-modulated light tomography. , 2003, Optics letters.

[19]  G. Maret,et al.  Ultrasonic modulation of multiply scattered light , 1995 .

[20]  Glen William Brooksby,et al.  Comprehensive approach to breast cancer detection using light: photon localization by ultrasound modulation and tissue characterization by spectral discrimination , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[21]  F. Jöbsis Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. , 1977, Science.

[22]  Friso Schlottau,et al.  Broadband radio-frequency spectrum analysis in spectral-hole-burning media. , 2006, Applied optics.

[23]  Gopi Maguluri,et al.  Detection of ultrasound-modulated photons in diffuse media using the photorefractive effect. , 2004, Optics letters.

[24]  Lihong V. Wang Mechanisms of ultrasonic modulation of multiply scattered coherent light: an analytic model. , 2001 .

[25]  Azriel Z. Genack,et al.  Acousto-optic tomography with multiply scattered light , 1997 .

[26]  Mitsunaga,et al.  Generalized perturbation theory of coherent optical emission. , 1985, Physical review. A, General physics.

[27]  Diane Dalecki,et al.  Mechanical bioeffects of ultrasound. , 2004, Annual review of biomedical engineering.

[28]  In situ monitoring of the photorefractive response time in a self-adaptive wavefront holography setup developed for acousto-optic imaging. , 2007, Optics express.

[29]  K. Wagner,et al.  Ultrawideband coherent noise lidar range-Doppler imaging and signal processing by use of spatial-spectral holography in inhomogeneously broadened absorbers. , 2006, Applied optics.

[30]  Philip Hemmer,et al.  Photorefractive detection of tissue optical and mechanical properties by ultrasound modulated optical tomography. , 2007, Optics letters.

[31]  Lihong V. Wang,et al.  High-resolution ultrasound-modulated optical tomography in biological tissues. , 2004, Optics letters.