An Innovative Ergometer to Measure Neuromuscular Fatigue Immediately after Cycling

Purpose When assessing neuromuscular fatigue (NMF) from dynamic exercise using large muscle mass (e.g., cycling), most studies have delayed measurement for 1 to 3 min after task failure. This study aimed to determine the reliability of an innovative cycling ergometer permitting the start of fatigue measurement within 1 s after cycling. Methods Twelve subjects participated in two experimental sessions. Knee-extensor NMF was assessed by electrical nerve and transcranial magnetic stimulation with both a traditional chair setup (PRE- and POST-Chair, 2 min postexercise) and the new cycling ergometer (PRE, every 3 min during incremental exercise and POST-Bike, at task failure). Results The reduction in maximal voluntary contraction force POST-Bike (63% ± 12% PRE; P < 0.001) was not different between sessions and there was excellent reliability at PRE-Bike (intraclass correlation coefficient [ICC], 0.97; coefficients of variation [CV], 3.2%) and POST-Bike. Twitch (Tw) and high-frequency paired-pulse (Db100) forces decreased to 53% ± 14% and 62% ± 9% PRE, respectively (P < 0.001). Both were reliable at PRE-Bike (Tw: ICC, 0.97; CV, 5.2%; Db100: ICC, 0.90; CV, 7.3%) and POST-Bike (Tw: ICC, 0.88; CV, 11.9; Db100: ICC, 0.62; CV, 9.0%). Voluntary activation did not change during the cycling protocol (P > 0.05). Vastus lateralis and rectus femoris M-wave and motor-evoked potential areas showed fair to excellent reliability (ICC, 0.45–0.88). The reduction in maximal voluntary contraction and Db100 was greater on the cycling ergometer than the isometric chair. Conclusions The innovative cycling ergometer is a reliable tool to assess NMF during and immediately postexercise. This will allow fatigue etiology during dynamic exercise with large muscle mass to be revisited in various populations and environmental conditions.

[1]  Vincent Martin,et al.  Electrical stimulation for testing neuromuscular function: from sport to pathology , 2011, European Journal of Applied Physiology.

[2]  H. Westerblad,et al.  What limits exercise during high-intensity aerobic exercise? , 2010, European Journal of Applied Physiology.

[3]  M. Amann,et al.  Fatigue diminishes motoneuronal excitability during cycling exercise. , 2016, Journal of neurophysiology.

[4]  Samuele M. Marcora,et al.  Reliability of a Novel High Intensity One Leg Dynamic Exercise Protocol to Measure Muscle Endurance , 2016, PloS one.

[5]  A. Cresswell,et al.  Motor cortex excitability does not increase during sustained cycling exercise to volitional exhaustion. , 2012, Journal of applied physiology.

[6]  D. Cicchetti,et al.  Developing criteria for establishing interrater reliability of specific items: applications to assessment of adaptive behavior. , 1981, American journal of mental deficiency.

[7]  S C Gandevia,et al.  Reliability of measurements of muscle strength and voluntary activation using twitch interpolation , 1995, Muscle & nerve.

[8]  J. L. Taylor,et al.  Recovery of central and peripheral neuromuscular fatigue after exercise. , 2017, Journal of applied physiology.

[9]  L. Romer,et al.  Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans , 2007, The Journal of physiology.

[10]  T. Noakes,et al.  The development of peripheral fatigue and short‐term recovery during self‐paced high‐intensity exercise , 2013, The Journal of physiology.

[11]  S. Gandevia.  Spinal and supraspinal factors in human muscle fatigue. , 2001, Physiological reviews.

[12]  S C Gandevia,et al.  Supraspinal fatigue during intermittent maximal voluntary contractions of the human elbow flexors. , 2000, Journal of applied physiology.

[13]  W G Hopkins,et al.  Measures of Reliability in Sports Medicine and Science , 2000, Sports medicine.

[14]  T. Noakes,et al.  Central Regulation and Neuromuscular Fatigue during Exercise of Different Durations. , 2016, Medicine and science in sports and exercise.

[15]  B Stapelfeldt,et al.  Development and Evaluation of a New Bicycle Instrument for Measurements of Pedal Forces and Power Output in Cycling , 2006, International journal of sports medicine.

[16]  Charles L Rice,et al.  Fatigue and recovery of power and isometric torque following isotonic knee extensions. , 2005, Journal of applied physiology.

[17]  G. Millet,et al.  Reliability of the functional measures of the corticospinal pathways to dorsiflexor muscles during maximal voluntary contractions , 2016, Journal of the Neurological Sciences.

[18]  G. Sjøgaard,et al.  Dynamic knee extension as model for study of isolated exercising muscle in humans. , 1985, Journal of applied physiology.

[19]  Gabrielle Todd,et al.  Measurement and reproducibility of strength and voluntary activation of lower‐limb muscles , 2004, Muscle & nerve.

[20]  J. L. Taylor,et al.  Changes in motor cortical excitability during human muscle fatigue. , 1996, The Journal of physiology.

[21]  R. Casaburi,et al.  Instantaneous quantification of skeletal muscle activation, power production, and fatigue during cycle ergometry. , 2015, Journal of applied physiology.

[22]  M. Amann,et al.  Group III/IV locomotor muscle afferents alter motor cortical and corticospinal excitability and promote central fatigue during cycling exercise , 2017, Clinical Neurophysiology.

[23]  J. Siegler,et al.  The differential effect of metabolic alkalosis on maximum force and rate of force development during repeated, high-intensity cycling. , 2013, Journal of applied physiology.

[24]  T. Carroll,et al.  Cortical voluntary activation of the human knee extensors can be reliably estimated using transcranial magnetic stimulation , 2009, Muscle & nerve.

[25]  David S. Kennedy,et al.  Effects of fatigue on corticospinal excitability of the human knee extensors , 2016, Experimental physiology.

[26]  Dean C. Hay,et al.  Neuromuscular fatigue of the knee extensors during repeated maximal intensity intermittent‐sprints on a cycle ergometer , 2015, Muscle & nerve.

[27]  J. Collett,et al.  Reliability of single and paired‐pulse transcranial magnetic stimulation in the vastus lateralis muscle , 2015, Muscle & nerve.

[28]  M. Jubeau,et al.  Severe hypoxia affects exercise performance independently of afferent feedback and peripheral fatigue. , 2012, Journal of applied physiology.

[29]  J. McDaniel,et al.  Muscle mass and peripheral fatigue: a potential role for afferent feedback? , 2012, Acta physiologica.

[30]  P A Merton,et al.  Fatigue of long duration in human skeletal muscle after exercise. , 1977, The Journal of physiology.

[31]  Antonio J. Morales-Artacho,et al.  Effects of warm‐up on hamstring muscles stiffness: Cycling vs foam rolling , 2017, Scandinavian journal of medicine & science in sports.

[32]  A. St. Clair Gibson,et al.  Central and peripheral fatigue in male cyclists after 4-, 20-, and 40-km time trials. , 2015, Medicine and science in sports and exercise.

[33]  S. Goodall,et al.  Voluntary activation of human knee extensors measured using transcranial magnetic stimulation , 2009, Experimental physiology.

[34]  P. Arnal,et al.  Central fatigue assessed by transcranial magnetic stimulation in ultratrail running. , 2014, Medicine and science in sports and exercise.

[35]  D. Allen,et al.  Intracellular calcium concentration during low-frequency fatigue in isolated single fibers of mouse skeletal muscle. , 1993, Journal of applied physiology.

[36]  Samuele M. Marcora,et al.  Central alterations of neuromuscular function and feedback from group III-IV muscle afferents following exhaustive high-intensity one-leg dynamic exercise. , 2015, American journal of physiology. Regulatory, integrative and comparative physiology.

[37]  B. Wuyam,et al.  Neuromuscular fatigue and exercise capacity in fibromyalgia syndrome , 2013, Arthritis care & research.

[38]  Alain Martin,et al.  Assessment of the reliability of central and peripheral fatigue after sustained maximal voluntary contraction of the quadriceps muscle , 2007, Muscle & nerve.

[39]  P. Arnal,et al.  Does central fatigue explain reduced cycling after complete sleep deprivation? , 2013, Medicine and science in sports and exercise.

[40]  B. Wuyam,et al.  Quadriceps function assessment using an incremental test and magnetic neurostimulation: a reliability study. , 2013, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[41]  B. Wuyam,et al.  Comparison of electrical and magnetic stimulations to assess quadriceps muscle function. , 2009, Journal of applied physiology.

[42]  J T Viitasalo.  Effects of pretension on isometric force production. , 1982, International journal of sports medicine.

[43]  Håkan Westerblad,et al.  Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres , 2010 .

[44]  M. Jubeau,et al.  Changes in Voluntary Activation Assessed by Transcranial Magnetic Stimulation during Prolonged Cycling Exercise , 2014, PloS one.

[45]  K. R. Mills,et al.  Silent period to transcranial magnetic stimulation: construction and properties of stimulus–response curves in healthy volunteers , 2005, Experimental Brain Research.

[46]  Romuald Lepers,et al.  Neuromuscular fatigue during a long-duration cycling exercise. , 2002, Journal of applied physiology.

[47]  B. MacIntosh,et al.  What is fatigue? , 2002, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[48]  G. Millet,et al.  Resting and active motor thresholds versus stimulus–response curves to determine transcranial magnetic stimulation intensity in quadriceps femoris , 2014, Journal of NeuroEngineering and Rehabilitation.