In C 57 Bl / 6 mice FcγRIIB deficiency amplifies spontaneous autoimmunity caused by other loci

1 Department of Human Genetics, 2 Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands 3 Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial Collage, London, UK 4 Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland 5 Renal Immunopathology Laboratory, Fondazione D’Amico per la Ricerca sulle Malattie Renali, c/o San Carlo Borromeo Hospital, Milan, Italy 6 Department of Immunology, Erasmus MC, Rotterdam, the Netherlands 7 Department of Histopathology, Imperial Collage, London, UK

[1]  S. Akira,et al.  Evidence for Genes in Addition to Tlr7 in the Yaa Translocation Linked with Acceleration of Systemic Lupus Erythematosus1 , 2008, The Journal of Immunology.

[2]  W. B. van den Berg,et al.  Destructive Arthritis in the Absence of Both FcγRI and FcγRIII1 , 2008, The Journal of Immunology.

[3]  H. Kole,et al.  A Lupus-Suppressor BALB/c Locus Restricts IgG2 Autoantibodies without Altering Intrinsic B Cell-Tolerance Mechanisms1 , 2008, The Journal of Immunology.

[4]  T. Manser,et al.  Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production , 2007, Genes and Immunity.

[5]  S. Camper,et al.  Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line , 2007, Mammalian Genome.

[6]  Kutty Selva Nandakumar,et al.  Backcross and Partial Advanced Intercross Analysis of Nonobese Diabetic Gene-Mediated Effects on Collagen-Induced Arthritis Reveals an Interactive Effect by Two Major Loci1 , 2006, The Journal of Immunology.

[7]  B. Diamond,et al.  Selective dysregulation of the FcγIIB receptor on memory B cells in SLE , 2006, The Journal of Experimental Medicine.

[8]  Matthias Kretzler,et al.  Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice , 2006, Nature Medicine.

[9]  Quanzhen Li,et al.  A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[10]  C. Mohan,et al.  Regulation of B Cell Tolerance by the Lupus Susceptibility Gene Ly108 , 2006, Science.

[11]  A. Satterthwaite,et al.  Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication , 2006, Science.

[12]  M. Madaio,et al.  The Journal of Experimental Medicine CORRESPONDENCE , 2005 .

[13]  K. Tokunaga,et al.  FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling , 2005 .

[14]  Janet M. Allen,et al.  Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts , 2005, Nature Medicine.

[15]  A. Pertsemlidis,et al.  Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. , 2004, Immunity.

[16]  M. Walport,et al.  Open access, freely available online PLoS BIOLOGY Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice , 2022 .

[17]  Kutty Selva Nandakumar,et al.  Induction of arthritis by single monoclonal IgG anti‐collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcγRIIB , 2003, European journal of immunology.

[18]  A. Nakamura,et al.  FcγRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease , 2003, European journal of immunology.

[19]  Kenneth G. C. Smith,et al.  B cell inhibitory receptors and autoimmunity , 2003, Immunology.

[20]  P. Heeringa,et al.  Opposite Regulation of Type II and III Receptors for Immunoglobulin G in Mouse Glomerular Mesangial Cells and in the Induction of Anti-glomerular Basement Membrane (GBM) Nephritis* , 2002, The Journal of Biological Chemistry.

[21]  E. Wakeland,et al.  Genetic Modifiers of Systemic Lupus Erythematosus in FcγRIIB−/− Mice , 2002, The Journal of experimental medicine.

[22]  T. Behrens,et al.  Delineating the genetic basis of systemic lupus erythematosus. , 2001, Immunity.

[23]  P. Taylor,et al.  Accelerated Nephrotoxic Nephritis Is Exacerbated in C1q-Deficient Mice1 , 2001, The Journal of Immunology.

[24]  J. Ravetch,et al.  Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. , 2000, Immunity.

[25]  S. Hirose,et al.  Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility , 2000, Immunogenetics.

[26]  M. Ono,et al.  Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. , 2000, The Journal of experimental medicine.

[27]  Kenneth G. C. Smith,et al.  Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcγRII , 2000, Current Biology.

[28]  C. Benoist,et al.  Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. , 1999, Science.

[29]  P. Butler,et al.  Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity , 1999, Nature Medicine.

[30]  T. Yoshino,et al.  Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG , 1999, The Journal of experimental medicine.

[31]  K. Rajewsky,et al.  From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. , 1999, Immunity.

[32]  M. Ono,et al.  Modulation of Immune Complex–induced Inflammation In Vivo by the Coordinate Expression of Activation and Inhibitory Fc Receptors , 1999, The Journal of experimental medicine.

[33]  C. Goodnow,et al.  A critical role for complement in maintenance of self-tolerance. , 1998, Immunity.

[34]  J. Ravetch,et al.  Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis. , 1998, Kidney international.

[35]  T. Yamazaki,et al.  Resistance of Fc receptor- deficient mice to fatal glomerulonephritis. , 1998, The Journal of clinical investigation.

[36]  J. Ravetch,et al.  Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. , 1998, Science.

[37]  V. Kouskoff,et al.  Organ-Specific Disease Provoked by Systemic Autoimmunity , 1996, Cell.

[38]  F. Alt,et al.  Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[39]  R. Kimberly,et al.  Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. , 2007, Journal of immunology.

[40]  E. Paul,et al.  Follicular exclusion of autoreactive B cells requires FcgammaRIIb. , 2007, International immunology.

[41]  J. Ravetch,et al.  The inhibitory Fcγ receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells , 2005, Nature Immunology.

[42]  S. Kanba,et al.  Avoiding the effect of linked genes is crucial to elucidate the role of Apcs in autoimmunity , 2005, Nature Network Boston.

[43]  T. Takai Fc Receptors and Their Role in Immune Regulation and Autoimmunity , 2005, Journal of Clinical Immunology.

[44]  C. Kallenberg,et al.  Fcgamma receptors in the initiation and progression of systemic lupus erythematosus. , 2003, Immunology and cell biology.

[45]  M. Corr,et al.  The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. , 2002, Journal of immunology.

[46]  R. Schmidt,et al.  Mouse FcgammaRII is a negative regulator of FcgammaRIII in IgG immune complex-triggered inflammation but not in autoantibody-induced hemolysis. , 2000, European journal of immunology.

[47]  R. Schmidt,et al.  Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. , 1996, Immunity.

[48]  M. Ono,et al.  Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. , 1996, Nature.