Comparison of the electrophysiologically based optimization methods with different pacing parameters in patient undergoing resynchronization treatment

Many studies conducted on patients suffering from congestive heart failure have shown the efficacy of cardiac resynchronization therapy (CRT). The presented research investigates an off-line optimization algorithm based on different electrode positioning and timing delays. A computer model of the heart was used to simulate left bundle branch block (LBBB), myocardial infarction (MI) and reduction of intraventricular conduction velocity in order to customize the patient symptom. The optimization method evaluates the error between the healthy heart and pathology with/without pacing in terms of activation time and QRS length. Additionally, a torso model of the patient is extracted to compute the body surface potential map (BSPM) and to simulate the ECG with Wilson leads to validate the results obtained by the electrophysiological heart model optimization.

[1]  Gunnar Seemann,et al.  Modeling of force development in the human heart with a cellular automaton parameterized by numerical simulations , 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

[2]  Matthias Reumann,et al.  Computer assisted optimisation on non-pharmacological treatment of congestive heart failure and supraventricular arrhythmia , 2007 .

[3]  M. Cerqueira,et al.  Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association , 2002, The international journal of cardiovascular imaging.

[4]  D. Noble,et al.  A model for human ventricular tissue. , 2004, American journal of physiology. Heart and circulatory physiology.

[5]  Albert Meijer,et al.  Correlation of echo-Doppler optimization of atrioventricular delay in cardiac resynchronization therapy with invasive hemodynamics in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. , 2006, The American journal of cardiology.

[6]  D. Shah,et al.  Optimization of Device Programming for Cardiac Resynchronization Therapy , 2006, Pacing and clinical electrophysiology : PACE.

[7]  E. Foster,et al.  Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias. , 2003, Journal of the American College of Cardiology.

[8]  Won Yong Kim,et al.  Impact of Acute Biventricular Pacing on Left Ventricular Performance and Volumes in Patients with Severe Heart Failure , 2001, Cardiology.

[9]  Lisa Hartling,et al.  Systematic Review: Cardiac Resynchronization in Patients with Symptomatic Heart Failure , 2004, Annals of Internal Medicine.

[10]  O. Dossel,et al.  Computer Based Optimization of Biventricular Pacing According to the Left Ventricular 17 Myocardial Segments , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[11]  Olaf Dössel,et al.  Computer model for the optimization of AV and VV delay in cardiac resynchronization therapy , 2007, Medical & Biological Engineering & Computing.

[12]  M. Cerqueira,et al.  Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. , 2002, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[13]  B. Kristensen,et al.  Sequential Versus Simultaneous Biventricular Resynchronization for Severe Heart Failure: Evaluation by Tissue Doppler Imaging , 2002, Circulation.

[14]  C. Visser,et al.  Comparison of the haemodynamics of different pacing sites in patients undergoing resynchronisation treatment: need for individualisation of lead localisation , 2006, Heart.

[15]  A. Hughes,et al.  Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay , 2006, Heart.

[16]  Paolo Rizzon,et al.  Clinical Application of Echocardiographic Findings Cardiac Resynchronization Therapy Tailored by Echocardiographic Evaluation of Ventricular Asynchrony , 2016 .

[17]  L. Hsu,et al.  Treatment of heart failure--role of biventricular pacing for heart failure not responding well to drug therapy. , 2003, Singapore medical journal.