Immunomodulatory Activity of Naturally Occurring Monoterpenes Carvone, Limonene, and Perillic Acid

The immunomodulatory activity of some naturally occurring monoterpenes were studied in Balb/c mice. Administration of various monoterpenes such as carvone (100 μmoles/Kg body wt/dose/animal), limonene (100 μmoles/Kg body wt/dose/animal) and perillic acid (50 μmoles/Kg body wt/dose/animal) were found to increase the total white blood cells (WBC) count in Balb/c mice. The maximum total WBC count in carvone treated animals was observed on the 12th day (16560 cells/cmm) while in limonene (13783 cells/cmm) and perillic acid (14437 cells/cmm) treated animals the maximum count was observed on the 9th day after the drug treatment. Administration of terpenoids increased the total antibody production, antibody producing cells in spleen, bone marrow cellularity and α-esterase positive cells significantly compared to the normal animals indicating its potentiating effect on the immune system.

[1]  J. Potter,et al.  Vegetables, fruit, and cancer. I. Epidemiology , 1991, Cancer Causes & Control.

[2]  M. Jiménez-Estrada,et al.  Antifungal monoterpene production in elicited cell suspension cultures of Piqueria trinervia. , 2000, Phytochemistry.

[3]  L. Davis,et al.  Immunomodulatory activity of Withania somnifera. , 2000, Journal of ethnopharmacology.

[4]  L. Davis,et al.  Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. , 2000, Cancer letters.

[5]  G. Kuttan,et al.  Immunomodulatory and antitumour activities of Tinospora cordifolia , 1999 .

[6]  G. Kuttan,et al.  Immunomodulatory activity of curcumin. , 1999, Immunological investigations.

[7]  R. Kuttan,et al.  Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity. , 1998, Journal of experimental & clinical cancer research : CR.

[8]  L. Davis,et al.  Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. , 1998, Journal of ethnopharmacology.

[9]  D. Biondi,et al.  Relationship between volatile components of citrus fruit essential oils and antimicrobial action on Penicillium digitatum and penicillium italicum. , 1998, International journal of food microbiology.

[10]  M. Gould.  Cancer chemoprevention and therapy by monoterpenes. , 1997, Environmental health perspectives.

[11]  G. Kuttan,et al.  Use of Withania somnifera Dunal as an adjuvant during radiation therapy. , 1996, Indian journal of experimental biology.

[12]  C. Roques,et al.  Comparison of antimicrobial properties of monoterpenes and their carbonylated products. , 1996, Planta medica.

[13]  M. Ziauddin,et al.  Studies on the immunomodulatory effects of Ashwagandha. , 1996, Journal of ethnopharmacology.

[14]  A. Rogers.  Integrated environmental control , 1993, The Lancet.

[15]  D. McNamee.  Limonene trial in cancer , 1993, The Lancet.

[16]  R. Kuttan,et al.  Chemoprotective effect of curcumin against cyclophosphamide toxicity. , 1992 .

[17]  G. Kuttan,et al.  Immunomodulatory activity of a peptide isolated from Viscum album extract (NSC 635 089). , 1992, Immunological investigations.

[18]  G. Bárány,et al.  Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. , 1989, Cancer research.

[19]  S. Agarwal,et al.  Immunomodulatory Activity of Panax ginseng Extract , 1984, Planta medica.

[20]  M N Gould,et al.  Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. , 1984, Carcinogenesis.

[21]  P. Lagrange,et al.  INFLUENCE OF DOSE AND ROUTE OF ANTIGEN INJECTION ON THE IMMUNOLOGICAL INDUCTION OF T CELLS , 1974, The Journal of experimental medicine.

[22]  N. K. Jerne,et al.  Plaque Formation in Agar by Single Antibody-Producing Cells , 1963, Science.