Single subthalamic nucleus neurons project to both the globus pallidus and substantia nigra in rat

The organization of the major efferents of the rat subthalamic nucleus (STN) was investigated using a fluorescent retrograde double‐labeling technique. Red fluorcrescent Evans Blue was injected into the globus pallidus and blue fluorescent DAPI‐Primuline was injected into the substantia nigra. After retrograde axonal transport many double‐labeled neurons were seen throughout the STN. Occasional double‐labeled cells were seen in the lateral hypothalamus just medial to the STN and in a thin lateral strip of neurons extending laterally from the STN. Evidence for a mediolateral topography in both the STN‐pallidal and STN‐nigral pathways was obtained.

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