On the Use of Computational Fluid Dynamics (CFD) Modelling to Design Improved Dry Powder Inhalers

1 School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, Australia Laboratory for Turbulence Research in Aerospace and Combustion (LTRAC), Department of Mechanical and Aerospace Engineering, Monash University, Clayton Campus, Melbourne, Australia Respiratory Technology, Woolcock Institute of Medical Research and Discipline of Pharmacology, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia Corresponding author: vishal.chaugule@monash.edu

[1]  Worth Longest,et al.  Development of a New Inhaler for High-Efficiency Dispersion of Spray-Dried Powders Using Computational Fluid Dynamics (CFD) Modeling , 2019, The AAPS Journal.

[2]  Gary J. Brown,et al.  Application of hybrid RANS-LES models to the prediction of flow behaviour in an industrial crystalliser , 2020 .

[3]  F. Nicoud,et al.  Subgrid-Scale Stress Modelling Based on the Square of the Velocity Gradient Tensor , 1999 .

[4]  C. Kiparissides,et al.  eposition and fine particle production during dynamic flow n a dry powder inhaler : A CFD approach , 2013 .

[5]  Andrzej F. Nowakowski,et al.  Modified shear stress transport model with curvature correction for the prediction of swirling flow in a cyclone separator , 2016 .

[6]  F. Menter,et al.  Stress-Blended Eddy Simulation (SBES)—A New Paradigm in Hybrid RANS-LES Modeling , 2016 .

[7]  Costas Kiparissides,et al.  Flow and Particle Deposition in the Turbuhaler DPI - A CFD Simulation , 2013, BIODEVICES.

[8]  Florian R. Menter,et al.  Sensitization of the SST Turbulence Model to Rotation and Curvature by Applying the Spalart–Shur Correction Term , 2009 .

[9]  S. Kær,et al.  Comparison of Reynolds averaged Navier-Stokes based simulation and large-eddy simulation for one isothermal swirling flow , 2012 .

[10]  F. Menter Two-equation eddy-viscosity turbulence models for engineering applications , 1994 .

[11]  David F. Fletcher,et al.  Influence of Air Flow on the Performance of a Dry Powder Inhaler Using Computational and Experimental Analyses , 2005, Pharmaceutical Research.

[12]  Judy A Raper,et al.  Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. , 2006, Journal of pharmaceutical sciences.

[13]  Bruno C. Hancock,et al.  The coefficient of restitution of some pharmaceutical tablets/compacts. , 2010, International journal of pharmaceutics.

[14]  Aerodynamic Factors Responsible for the Deaggregation of Carrier-Free Drug Powders to Form Micrometer and Submicrometer Aerosols , 2013, Pharmaceutical Research.

[15]  Gerad Klaas Bolhuis,et al.  THE RELATIONSHIP BETWEEN BULK-DENSITY AND COMPACTIBILITY OF LACTOSE GRANULATIONS , 1994 .

[16]  William Wong,et al.  The use of computational approaches in inhaler development. , 2012, Advanced drug delivery reviews.

[17]  D. Fletcher,et al.  In-vitro and Particle Image Velocimetry Studies of Dry Powder Inhalers. , 2020, International journal of pharmaceutics.

[18]  Nazrul Islam,et al.  Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery--a review for multidisciplinary researchers. , 2012, Medical engineering & physics.

[19]  M. Sommerfeld,et al.  Potential and constraints for the application of CFD combined with Lagrangian particle tracking to dry powder inhalers , 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[20]  Martin J. Donovan,et al.  Dry powder inhaler device influence on carrier particle performance. , 2012, Journal of pharmaceutical sciences.

[21]  M. Sommerfeld,et al.  Numerical Analysis of Carrier Particle Motion in a Dry Powder Inhaler , 2016 .

[22]  T. Shih,et al.  A new k-ϵ eddy viscosity model for high reynolds number turbulent flows , 1995 .

[23]  Judy A Raper,et al.  Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length. , 2004, Journal of pharmaceutical sciences.