The p65 subunit of NF-kB binds to PGC-1a, linking inflammation and metabolic disturbances in cardiac cells

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The p65 subunit of NF-kB binds to PGC-1a, linking inflammation and metabolic disturbances in cardiac cells

[1]  Xianlin Han,et al.  The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. , 2008, American journal of physiology. Heart and circulatory physiology.

[2]  A. Garnier,et al.  Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. , 2008, Cardiovascular research.

[3]  D. Kelly,et al.  Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. , 1996, Circulation.

[4]  S. Ball,et al.  Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones. , 2007, Cardiovascular research.

[5]  D. Kelly,et al.  Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. , 2007, Circulation.

[6]  A. Hoffmann,et al.  A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. , 2005, Genes & development.

[7]  D. Graves,et al.  FOXO1 Functions as a Master Switch That Regulates Gene Expression Necessary for Tumor Necrosis Factor-induced Fibroblast Apoptosis* , 2005, Journal of Biological Chemistry.

[8]  T. Chan,et al.  TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model. , 2009, Cardiovascular research.

[9]  S. Yuasa,et al.  Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor gamma coactivator 1alpha. , 2007, The Journal of biological chemistry.

[10]  N. Andrews,et al.  A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. , 1991, Nucleic acids research.

[11]  Rama Natarajan,et al.  In Vivo Chromatin Remodeling Events Leading to Inflammatory Gene Transcription under Diabetic Conditions* , 2004, Journal of Biological Chemistry.

[12]  A. Koretsky,et al.  Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α , 1997 .

[13]  H. Nakano,et al.  Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Junfeng Zhang,et al.  Free fatty acids increase PGC-1alpha expression in isolated rat islets. , 2005, FEBS letters.

[15]  S. Mccune,et al.  Myocardial tumor necrosis factor-alpha secretion in hypertensive and heart failure-prone rats. , 1999, The American journal of physiology.

[16]  Jiandie D. Lin,et al.  Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. , 2004, Genes & development.

[17]  S. Reed,et al.  SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. , 2008, Genes & development.

[18]  M. Birnbaum,et al.  Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator , 2007, Nature.

[19]  David C. Young,et al.  Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. , 2008, Journal of molecular biology.

[20]  S. Soyal,et al.  PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes. , 2006, Diabetologia.

[21]  P. C. Chin,et al.  Akt is a downstream target of NF-kappa B. , 2002, The Journal of biological chemistry.

[22]  Simon C Watkins,et al.  Mitochondrial Abnormalities in Tumor Necrosis Factor-&agr;–Induced Heart Failure Are Associated With Impaired DNA Repair Activity , 2001, Circulation.

[23]  G. Bifulco,et al.  In Skeletal Muscle, Glucose Storage and Oxidation Are Differentially Impaired by the IR1152 Mutant Receptor* , 1997, The Journal of Biological Chemistry.

[24]  W. Farrar,et al.  Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. , 2007, Blood.

[25]  D. Kressler,et al.  Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[26]  C. Rücker-Martin,et al.  Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation. , 2003, Cardiovascular research.

[27]  P. Puigserver,et al.  Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. , 2000, Molecular cell.

[28]  A. Fukamizu,et al.  Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. , 2007, Cellular signalling.

[29]  Anna Planavila,et al.  Nuclear Factor-κB Activation Leads to Down-regulation of Fatty Acid Oxidation during Cardiac Hypertrophy* , 2005, Journal of Biological Chemistry.

[30]  A. Fukamizu,et al.  Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. , 2003, Diabetes.

[31]  M. Fu,et al.  TNFα-antagonist neither improve cardiac remodelling or cardiac function at early stage of heart failure in diabetic rats , 2008, Autoimmunity.

[32]  Robert A. Harris,et al.  Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. , 2008, American journal of physiology. Heart and circulatory physiology.

[33]  P. Gómez-Puertas,et al.  Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation. , 2006, Biochemistry.

[34]  M. Hirano,et al.  Novel cell lines derived from adult human ventricular cardiomyocytes. , 2005, Journal of molecular and cellular cardiology.

[35]  M. Quiñones,et al.  Cardiac Hypertrophy After Transplantation Is Associated With Persistent Expression of Tumor Necrosis Factor-&agr; , 2001, Circulation.

[36]  S. Nemoto,et al.  Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha). , 2002, The Journal of biological chemistry.

[37]  L. Kirshenbaum,et al.  Antagonism of E2F-1 regulated Bnip3 transcription by NF-κB is essential for basal cell survival , 2008, Proceedings of the National Academy of Sciences.

[38]  C. Glass,et al.  Transcriptional activation by NF-kappaB requires multiple coactivators. , 1999, Molecular and cellular biology.