论文信息 - Pharmacological Analysis of Locomotion and Heart Contraction During the Development of Helisoma (Mollusca: Gastropoda)

Pharmacological Analysis of Locomotion and Heart Contraction During the Development of Helisoma (Mollusca: Gastropoda)

We investigated involvement of different 5-HT receptors in regulation of ciliary rotation, gliding locomotion and heartbeat of Helisoma embryo at pre- and post-metamorphic stages. Pharmacological analysis suggested that activation of 5-HT_1 receptor enhance ciliary rotation but do not affect gliding locomotion. Activation of 5-HT_4 receptor depresses both types of locomotion. Before metamorphosis heart contraction is depressed by activation of 5-HT_4 and enhanced by activation of 5-HT_7 receptor. However, the heart became insensitive to all agonists by hatching. We hypothesized that alterations in affinity or expression of particular 5-HT receptors can underlie the well-coordinated character of serotonin-dependent larval behavior.

E. Voronezhskaya | M. Khabarova

[1] W. Gallin,et al. Identification, molecular structure and expression of two cloned serotonin receptors from the pond snail, Helisoma trivolvis , 2008, Journal of Experimental Biology.

[2] E. Voronezhskaya,et al. Role of chemical signalling in release of motor programs during embryogenesis of freshwater snails Lymnaea stagnalis and Helisoma trivolvis , 2007, Russian Journal of Developmental Biology.

[3] E. Voronezhskaya,et al. Apical sensory neurones mediate developmental retardation induced by conspecific environmental stimuli in freshwater pulmonate snails , 2004, Development.

[4] T. Diefenbach,et al. Pharmacological characterization of a serotonin receptor involved in an early embryonic behavior of Helisoma trivolvis. , 1994, Journal of neurobiology.