Haemodynamics and myocardial function after sotalol.

The cardiovascular effects of the beta-adrenergic blocking agent, sotalol, have been assessed in a group ofpatients with heart disease. There was a significant reduction in heart rate and cardiac output, but stroke volume was unchanged. Systemic arterial andpulmonary artery pressures were not significantly altered. Indices of mryocardial function (dp/dt max and V max) were also significantly reduced. is of myocardial depression associated with other beta-adrenergic blocking drugs, sotalol has both a negative chronotropic and a lesser negative inotropic action.

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