Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis

Objectives  Nonalcoholic steatohepatitis (NASH), a metabolic disorder of the liver, may gradually evolve into fibrosis or cirrhosis. Recent studies have suggested that geniposide can effectively inhibit experimental liver fibrosis. Therefore, the aim of this study was to determine whether geniposide can influence the early phase of fibrogenesis in an animal model of NASH.

[1]  J. Gimble,et al.  Effect of Peroxisome Proliferator-Activated Receptor Alpha Activators on Tumor Necrosis Factor Expression in Mice during Endotoxemia , 1999, Infection and Immunity.

[2]  B. Neuschwander‐Tetri,et al.  Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions , 1999, American Journal of Gastroenterology.

[3]  I. Leclercq,et al.  CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. , 2000, The Journal of clinical investigation.

[4]  G. Marchesini,et al.  Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. , 2001, Diabetes.

[5]  G. Farrell,et al.  Etiopathogenesis of Nonalcoholic Steatohepatitis , 2001, Seminars in liver disease.

[6]  M. Reitman,et al.  WY14,643, a Peroxisome Proliferator-activated Receptor α (PPARα) Agonist, Improves Hepatic and Muscle Steatosis and Reverses Insulin Resistance in Lipoatrophic A-ZIP/F-1 Mice* , 2002, The Journal of Biological Chemistry.

[7]  J. Corton,et al.  Delayed liver regeneration in peroxisome proliferator‐activated receptor‐α‐null mice , 2002 .

[8]  M. Reitman,et al.  WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. , 2002, The Journal of biological chemistry.

[9]  E. Brunt Alcoholic and nonalcoholic steatohepatitis. , 2002, Clinics in liver disease.

[10]  J. Corton,et al.  Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice. , 2002, Hepatology.

[11]  Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis , 2003, Hepatology.

[12]  I. Leclercq,et al.  Central role of PPARα‐dependent hepatic lipid turnover in dietary steatohepatitis in mice , 2003, Hepatology.

[13]  N. Chalasani,et al.  Metabolic and anthropometric evaluation of insulin resistance in nondiabetic patients with nonalcoholic steatohepatitis , 2003, American Journal of Gastroenterology.

[14]  H. Yoshimatsu,et al.  Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice. , 2004, Hepatology.

[15]  H. Yoshimatsu,et al.  Adiponectin protects LPS‐induced liver injury through modulation of TNF‐α in KK‐Ay obese mice , 2004 .

[16]  J. Féher,et al.  [Treatment of non-alcoholic steatohepatitis]. , 2004, Orvosi hetilap.

[17]  G. Gores,et al.  O0040 FREE FATTY ACIDS PROMOTE HEPATIC LIPOTOXICITY BY STIMULATING TNF‐ALPHA EXPRESSION VIA A LYSOSOMAL PATHWAY , 2004, Journal of Pediatric Gastroenterology and Nutrition.

[18]  G. Gores,et al.  Free fatty acids promote hepatic lipotoxicity by stimulating TNF‐α expression via a lysosomal pathway , 2004 .

[19]  Y. Song,et al.  Antiinflammatory effects of genipin, an active principle of gardenia. , 2004, European journal of pharmacology.

[20]  J. Kench,et al.  Beyond insulin resistance in NASH: TNF‐α or adiponectin? , 2004, Hepatology.

[21]  K. Fujimori,et al.  Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis. , 2004, Journal of hepatology.

[22]  C. Lim,et al.  Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides. , 2004, Planta medica.

[23]  G. Pacini,et al.  Hypoadiponectinemia Predicts the Severity of Hepatic Fibrosis and Pancreatic Beta-Cell Dysfunction in Nondiabetic Nonobese Patients with Nonalcoholic Steatohepatitis , 2005, The American Journal of Gastroenterology.

[24]  P. Kar,et al.  Non-alcoholic steatohepatitis. , 2005, The Journal of the Association of Physicians of India.

[25]  B. Lowell,et al.  Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. , 2006, Cell metabolism.

[26]  G. Svegliati-Baroni,et al.  A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. , 2006, The American journal of pathology.

[27]  Y. Huang,et al.  High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. , 2006, Life sciences.

[28]  G. Farrell,et al.  Nonalcoholic fatty liver disease: From steatosis to cirrhosis , 2006, Hepatology.

[29]  Michelle M Wiest,et al.  A lipidomic analysis of nonalcoholic fatty liver disease , 2007, Hepatology.

[30]  A. Baranova,et al.  Adipokines and cytokines in non‐alcoholic fatty liver disease , 2007, Alimentary pharmacology & therapeutics.

[31]  A. Sehirli,et al.  Effects of N-acetylcysteine on regeneration following partial hepatectomy in rats with nonalcoholic fatty liver disease , 2009, Surgery Today.

[32]  Wei Xu,et al.  Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin , 2009, Acta Pharmacologica Sinica.

[33]  L. Poston,et al.  Maternal high‐fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression , 2009, Hepatology.

[34]  S. Harrison,et al.  NASH and HCC. , 2009, Clinics in liver disease.

[35]  Taotao Ma,et al.  Potential protective effects of a traditional Chinese herb, Litsea coreana Levl., on liver fibrosis in rats , 2010, The Journal of pharmacy and pharmacology.

[36]  G. Musso,et al.  Non‐alcoholic fatty liver disease from pathogenesis to management: an update , 2009, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[37]  T. Saibara,et al.  Effects of Eriobotrya japonica seed extract on oxidative stress in rats with non‐alcoholic steatohepatitis , 2010, The Journal of pharmacy and pharmacology.