The role of in silico tools in supporting the application of the substitution principle.

The Role of In Silico Tools in Supporting the Application of the Substitution Principle Alessandra Roncaglioni 1, Emilio Benfenati 1, Alberto Mantovani 2, Ferdinando Fiorino 3, Elisa Perissutti 3 and Stefano Lorenzetti 2 Istituto di Ricerche Farmacologiche “Mario Negri” (IRFMN), Department of Environmental Health Sciences, Laboratory of Environmental Toxicology and Chemistry, Milan, Italy; Istituto Superiore di Sanità (ISS), Department of Food Safety and Veterinary Public Health, Rome, Italy; Università degli Studi di Napoli “Federico II”, Department of Pharmacy, Naples, Italy