Brief Definitive Report

Phorbol myristate acetate [12-O-tetradecanoyl-phorbol-13-acetate(PMA)] is one of several biologically active substances derived from croton oil, which potentiate the action of a carcinogen in inducing epidermoid tumors of mouse skin (cf. reference 1 for review). Interest in the role of immune response in epidermal carcinogenesis prompted us to investigate possible effects of PMA on lymphocytes. We observed that PMA is a potent mitegen for human peripheral blood lymphocytes (2), an observation confirmed by several laboratories (3-6). In this report, we present evidence that PMA approximates phytohemagglutinin (PHA) in its mitogenic potency, yet acts selectively on a T-lymphocyte subpepulation that has high affinity for sheep erythrocytes (SRBC) and is distinct from that responsive to PHA.

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