Adherence to Medication Regimens: Updating a Complex Medical Issue

Clinicians face nonadherence as the norm in everyday medical practice. The literature suggests a number of techniques that are likely to increase adherence when incorporated into regular clinical practices and routines. Central to these guidelines appears to be the doctor-patient relationship. For instance, the physician who uses understandable language, encourages open doctor-patient exchange, fosters participation by patients in their own medical care, and creates a friendly and efficient environment should increase the likelihood of adherence. Clinicians can also check adherence to medication regimens by requesting patients to bring in their pill bottles (or other prescription containers) for a discussion on how the medication appears to be working for them. This should elicit information from the patient about problems related to medication adherence. Since patient variables and social support affect adherence behaviors, eliciting information from patients about their understanding and beliefs regarding their particular illness and treatment, as well as enlisting the support of family and friends, may encourage adherence. Identifying what individual patients perceive as obstacles in following treatment regimens decreases their likelihood of nonadherence; these are difficulties that can be negotiated during the medical interview. Individualizing the treatment and minimizing its complexity may provide the solution that encourages adherent behavior. Frequent reeducation, reinforcement, and encouragement, as well as training in self-management and self-monitoring, will at the very least maximize the patient's comprehension of the illness and his or her motivation for adherence--an especially important requisite for living with a chronic condition. Some patients may even wish to openly solicit family and friends for help in the management and monitoring of their illness and treatment, and to structure their environment to support adherence. Education programs for the patient featuring handouts and pamphlets that provide information about the illness in written and illustrated form have been used successfully. Education programs such as patient-oriented package inserts to accompany the medications and brief written summaries of complex treatment plans may also be useful. The purpose of such patient education adjuncts to illness and treatment lie in the hope that they will enhance the likelihood of following treatment recommendations. Through their use, the reason for the treatment and its potential effectiveness will, it is hoped, be better understood (Ley 1988). Overall, significant advances have been made in adherence research. Measurement systems have become more finely tuned, and the definitions and criteria for adherent behaviors are more clear and precise.(ABSTRACT TRUNCATED AT 400 WORDS)

[1]  B. Psaty,et al.  The Relative Risk of Incident Coronary Heart Disease Associated with Recently Stopping the Use of ??-Blockers , 1991 .

[2]  S. Wartman,et al.  When competent patients make irrational choices. , 1990, The New England journal of medicine.

[3]  Edward P. Sarafino,et al.  Health Psychology: Biopsychosocial Interactions , 1990 .

[4]  N. Col,et al.  The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. , 1990, Archives of internal medicine.

[5]  B. Psaty,et al.  The relative risk of incident coronary heart disease associated with recently stopping the use of beta-blockers. , 1990, JAMA.

[6]  B. Melamed,et al.  Social Support and Chronic Medical Stress: An Interaction-Based Approach , 1990 .

[7]  A. D’augelli,et al.  The contribution of personality characteristics to the relationship between social support and perceived physical health. , 1990, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[8]  S. Thompson,et al.  Patient-oriented interventions to improve communication in a medical office visit. , 1990, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[9]  Shelley E. Taylor,et al.  Victims' perceptions of social support: what is helpful from whom? , 1990, Journal of personality and social psychology.

[10]  J. Bloom,et al.  The relationship of social support and health. , 1990, Social science & medicine.

[11]  L. R. Strandberg,et al.  Underutilization of Antihypertensive Drugs and Associated Hospitalization , 1989, Medical care.

[12]  M. Dimatteo,et al.  Methodological issues in adherence to cancer control regimens. , 1989, Preventive medicine.

[13]  B. Carter Antihypertensive therapy in the elderly. , 1989, Primary care.

[14]  S. Kaplan,et al.  Assessing the Effects of Physician-Patient Interactions on the Outcomes of Chronic Disease , 1989, Medical care.

[15]  Y. Binik,et al.  Consistency of adherence across regimen demands. , 1989, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[16]  P. Rudd,et al.  Pill count measures of compliance in a drug trial: variability and suitability. , 1988, American journal of hypertension.

[17]  Judith A. Hall,et al.  Meta-analysis of Correlates of Provider Behavior in Medical Encounters , 1988, Medical care.

[18]  Schwartz Ls A biopsychosocial approach to the management of the diabetic patient. , 1988 .

[19]  P. Ley,et al.  Communicating with Patients: Improving Communication, Satisfaction and Compliance , 1988 .

[20]  Irwin G. Sarason,et al.  Social Support, Personality, and Health , 1988 .

[21]  R. Meermann,et al.  Chronic illness behavior and noncompliance with treatment: pathways to an interactional approach. , 1988, Psychotherapy and psychosomatics.

[22]  L. S. Schwartz A biopsychosocial approach to the management of the diabetic patient. , 1988, Primary care.

[23]  B. Devellis,et al.  Effects of Modeling on Patient Communication, Satisfaction, and Knowledge , 1987, Medical care.

[24]  H. Roth Measurement of compliance , 1987 .

[25]  T. Rosenthal,et al.  Home relaxation practice in hypertension treatment: objective assessment and compliance induction. , 1986, Journal of consulting and clinical psychology.

[26]  H. Adelman,et al.  Children's Reluctance Regarding Treatment: Incompetence, Resistance, or an Appropriate Response?. , 1986 .

[27]  L. W. Buckalew,et al.  Patient compliance and medication perception. , 1986, Journal of clinical psychology.

[28]  D. Rees Health beliefs and compliance with alcoholism treatment. , 1985, Journal of studies on alcohol.

[29]  I. Rosenstock Understanding and Enhancing Patient Compliance with Diabetic Regimens , 1985, Diabetes Care.

[30]  Caron Hs Compliance: the case for objective measurement. , 1985, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[31]  S. Kaplan,et al.  Expanding patient involvement in care. Effects on patient outcomes. , 1985, Annals of internal medicine.

[32]  H. Leventhal,et al.  I can tell when my blood pressure is up, can't I?". , 1985 .

[33]  John E. Ware,et al.  Expanding Patient Involvement in Care , 1985 .

[34]  G. Northcraft,et al.  Patient compliance behavior: the effects of time on patients' values of treatment regimens. , 1985, Social science & medicine.

[35]  P Conrad,et al.  The meaning of medications: another look at compliance. , 1985, Social science & medicine.

[36]  K. Brownell,et al.  Weight loss competitions at the work site: impact on weight, morale and cost-effectiveness. , 1984, American journal of public health.

[37]  M. Becker,et al.  The Health Belief Model: A Decade Later , 1984, Health education quarterly.

[38]  J. Kirscht,et al.  Understanding and improving patient compliance. , 1984, Annals of internal medicine.

[39]  I Heszen-Klemens,et al.  Doctor-patient interaction, patients' health behavior and effects of treatment. , 1984, Social science & medicine.

[40]  J. Fielding,et al.  Health promotion programs sponsored by California employers. , 1983, American journal of public health.

[41]  W. Hauser,et al.  The logic of noncompliance: Management of epilepsy from the patient's point of view , 1983, Culture, medicine and psychiatry.

[42]  Simonsson Bg,et al.  Strategies to improve patient compliance with antihypertensive therapy. , 1983 .

[43]  B. Simons-Morton,et al.  Strategies to improve patient compliance with antihypertensive therapy. , 1983, Primary care.

[44]  L. Epstein,et al.  A behavioral medicine perspective on adherence to long-term medical regimens. , 1982, Journal of consulting and clinical psychology.

[45]  P. Dubbert,et al.  Exercise and health: The adherence problem. , 1982 .

[46]  B. Masek Compliance and Medicine , 1982 .

[47]  B. Hoffman,et al.  Drug compliance and the psychiatric patient. , 1980, Canadian family physician Medecin de famille canadien.

[48]  W. Agras,et al.  Compliance with Medical Instructions , 1980 .

[49]  Peter P. Morgan,et al.  Compliance in Health Care , 1979 .

[50]  W. Baile,et al.  Hypertension: psychosomatic and behavioral aspects. , 1979, Primary care.

[51]  R. Brian Haynes,et al.  Compliance in Health Care , 1979 .

[52]  W. Stiles,et al.  Verbal response mode profiles of patients and physicians in medical screening interviews. , 1979, Journal of medical education.

[53]  D. Sackett Methods for compliance research , 1979 .

[54]  G. Stone,et al.  Patient Compliance and the Role of the Expert , 1979 .

[55]  D. Roter Patient Participation in the Patient-Provider Interaction: The Effects of Patient Question Asking on the Quality of Interaction, Satisfaction and Compliance* , 1977, Health education monographs.

[56]  K. Bertakis The communication of information from physician to patient: a method for increasing patient retention and satisfaction. , 1977, The Journal of family practice.

[57]  V. K. Jain,et al.  A method for decreasing patients' medication errors , 1977, Psychological Medicine.

[58]  P. Bradshaw,et al.  Increasing patients' satisfaction with communications. , 1976, The British journal of social and clinical psychology.

[59]  P. Rn,et al.  Compliance: a problem in medical management. , 1976 .

[60]  R. D. Eney,et al.  Compliance of chronic asthmatics with oral administration of theophylline as measured by serum and salivary levels. , 1976, Pediatrics.

[61]  R. Podell,et al.  Compliance: a problem in medical management. , 1976, American family physician.

[62]  S. Kasl Issues in patient adherence to health care regimens. , 1975, Journal of human stress.

[63]  T. Sharpe,et al.  Patient compliance with prescription medication regimens. , 1975, Journal of the American Pharmaceutical Association.

[64]  I. Rosenstock Historical Origins of the Health Belief Model , 1974 .

[65]  G. Stimson Obeying doctor's orders: a view from the other side. , 1974, Social science & medicine.

[66]  G. Hogarty,et al.  Drug and sociotherapy in the aftercare of schizophrenic patients. II. Two-year relapse rates. , 1974, Archives of general psychiatry.

[67]  G. Hogarty,et al.  Drug and sociotherapy in the aftercare of schizophrenic patients. One-year relapse rates. , 1973, Archives of general psychiatry.

[68]  H Aberg,et al.  PATIENT COMPLIANCE , 1973, MMW, Munchener medizinische Wochenschrift.

[69]  M. Becker,et al.  Motivations as predictors of health behavior. , 1972, Health services reports.

[70]  P. Ley Primacy, Rated Importance, and the Recall of Medical Statements , 1972 .

[71]  Perplexity, confusion and suspicion: a study of selected forms of doctor-patient interactions. , 1971, Social science & medicine.

[72]  M S Davis,et al.  Variation in Patients' Compliance with Doctors' Orders: Medical Practice and Doctor-Patient Interaction , 1971, Psychiatry in medicine.

[73]  H. Roth,et al.  Objective assessment of cooperation with an ulcer diet: relation to antacid intake and to assigned physician , 1971, The American journal of the medical sciences.

[74]  B. Korsch,et al.  Gaps in doctor-patient communication. Patients' response to medical advice. , 1969, The New England journal of medicine.

[75]  A. Lilienfeld,et al.  The Inaccuracy in Using Interviews to Estimate Patient Reliability in Taking Medications at Home , 1969, Medical care.

[76]  B. Korsch,et al.  Gaps in doctor-patient communication. 1. Doctor-patient interaction and patient satisfaction. , 1968, Pediatrics.

[77]  G. Albee,et al.  Patients' Beliefs about Peptic Ulcer and Its Treatment , 1962 .

[78]  T. Szasz,et al.  A contribution to the philosophy of medicine; the basic models of the doctor-patient relationship. , 1956, A.M.A. archives of internal medicine.