Lipoprotein Immunogenetics in Primates. I. Two Serum β‐Lipoprotein Allotypes (Lmb1 and Lmb11) in Rhesus Monkeys and the LP‐B Immunological Relationship With Other Primates

Immunogenetic investigations on two serum β‐lipoprotein allotypes of rhesus monkeys (Macaca mulatta) are reported. The allotypes, designated Lmb1 and Lmb11, are associated with the main lipoprotein family, LP‐B or β‐lipoprotein, expressed on independent β‐molecules, and classify rhesus monkeys into three phenotypes: Lmb1, Lmb11, and Lmb1,11. Genetic and molecular studies indicate that the allotypes are encoded by two codominant autosomal allelic genes, Lmb1 and Lmb11. Anti‐Lmb1 cross‐reacts with the sera of two other macaque species, whereas anti‐Lmb11 with sera of all Old World monkeys. Heteroimmune sera, antihuman apo‐B and antirhesus LP‐B, showed high but diversified degrees of cross reactivity with other primates.

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