Quantitative determination of magnetic beads using a magnetoimpedance-based lab-on-a-chip platform

This research aims at establishing a lab-on-a-chip platform based on giant magnetoimpedance (GMI) effect for quantitative determination of magnetic beads (MB). A micro-integrated GMI sensor consists of Cr/Cu/NiFe/Cu/NiFe/Al2O3/Cr/Au films that were prepared by Micro-Electro-Mechanical-Systems technology. Au film was integrated into GMI sensor for potential biochemical binding function, and quantitative immobilization of MB was performed on Au film of the GMI sensor. The GMI responses were significantly enhanced at high frequencies after coating MB on the sensing elements. This research offers scientific reference for further study and exploitation on quantitative determination of biomolecules by using the micro-integrated GMI sensor.

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