Investigation of expression and activity levels of primary rat hepatocyte detoxication genes under various flow rates and cell densities in microfluidic biochips
暂无分享,去创建一个
Laurent Griscom | Eric Leclerc | Patrick Paullier | Audrey Legendre | Régis Baudoin | L. Griscom | E. Leclerc | R. Baudoin | A. Legendre | S. Jacques | P. Paullier | M. Fleury | Marie Naudot | Marie-José Fleury | Sébastien Jacques | Giulia Alberto | Marie Naudot | Giulia Alberto
[1] Helmut Segner,et al. MEIC Evaluation of Acute Systemic Toxicity , 1998 .
[2] Teck Chuan Lim,et al. A microfluidic 3D hepatocyte chip for drug toxicity testing. , 2009, Lab on a chip.
[3] C. Bonfils,et al. Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture , 1997, Hepatology.
[4] Teruo Fujii,et al. Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device. , 2011, Biomicrofluidics.
[5] F. Bois,et al. Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions , 2012, BMC Genomics.
[6] U. Kristen,et al. In vitro cytotoxicity testing for prediction of acute human toxicity , 1994, Cell Biology and Toxicology.
[7] S. Bhatia,et al. In vitro zonation and toxicity in a hepatocyte bioreactor. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.
[8] Laurent Griscom,et al. Development of a Renal Microchip for In Vitro Distal Tubule Models , 2007, Biotechnology progress.
[9] M. Bayliss,et al. Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.
[10] Cécile Legallais,et al. Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs. , 2012, Analytical chemistry.
[11] S. Mccune,et al. Effect of cell density on metabolism in isolated rat hepatocytes , 1985, Journal of cellular physiology.
[12] Laurent Griscom,et al. Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. , 2012, Toxicology and applied pharmacology.
[13] L. Griffith,et al. Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor. , 2002, Tissue engineering.
[14] E. Walum,et al. MEIC Evaluation of Acute Systemic Toxicity , 1998 .
[15] Robert Combes,et al. Toxicity testing: creating a revolution based on new technologies. , 2005, Trends in biotechnology.
[16] Teruo Fujii,et al. Cell Culture in 3-Dimensional Microfluidic Structure of PDMS (polydimethylsiloxane) , 2003 .
[17] Luke P. Lee,et al. An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. , 2007, Biotechnology and bioengineering.
[18] B J Blaauboer,et al. The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary. , 2003, Toxicology letters.
[19] Cécile Legallais,et al. Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips , 2013, Xenobiotica; the fate of foreign compounds in biological systems.
[20] R. Chenery,et al. Diazepam metabolism in cultured hepatocytes from rat, rabbit, dog, guinea pig, and man. , 1987, Drug metabolism and disposition: the biological fate of chemicals.
[21] Z. Nie,et al. Microfluidic 3D cell culture: potential application for tissue-based bioassays. , 2012, Bioanalysis.
[22] P. Seglen. Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. , 1973, Experimental cell research.
[23] T. Nakamura,et al. Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell--cell contact and cell membranes. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[24] Shufang Zhang,et al. A robust high-throughput sandwich cell-based drug screening platform. , 2011, Biomaterials.
[25] M. Pfaffl,et al. A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.
[26] Matthew H. M. Lim,et al. Perfused multiwell plate for 3D liver tissue engineering. , 2010, Lab on a chip.
[27] Karl H. Clodfelter,et al. Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis. , 2004, Molecular endocrinology.
[28] K. Shakesheff,et al. Liver tissue engineering: a role for co-culture systems in modifying hepatocyte function and viability. , 2001, Tissue engineering.
[29] A. Ahluwalia,et al. Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes , 2011, Biotechnology journal.
[30] M. Toner,et al. Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor. , 2001, Biotechnology and bioengineering.
[31] Laurent Griscom,et al. Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor , 2011 .
[32] E. Leclerc,et al. Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells. , 2012, Molecular bioSystems.
[33] D. Cross,et al. Kinetics of ranitidine metabolism in dog and rat isolated hepatocytes. , 1995, Xenobiotica; the fate of foreign compounds in biological systems.
[34] L. Samson,et al. A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. , 2005, Current drug metabolism.
[35] Jos H Beijnen,et al. An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. , 2003, Toxicology and applied pharmacology.
[36] Cécile Legallais,et al. Parallelized microfluidic biochips in multi well plate applied to liver tissue engineering , 2012 .
[37] M. Yarmush,et al. Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human. , 2009, Biochemical pharmacology.