Immunophenotypic diagnosis of primary cutaneous lymphomas: a review for the practicing dermatologist.

The application of CD markers to medicine has advanced our understanding of several dermatological diseases, most notably primary cutaneous lymphomas. CD markers are monoclonal antibodies that target cell surface molecules on leukocytes and antigens from other cells. T-cell processes are typically CD3+, CD20-, CD45+ while B-cell processes are typically CD3-, CD20+, and CD45+. Other CD markers are used to further delineate cutaneous lymphomas. Although an imperfect system, CD markers empower dermatologists to synthesize immunophenotyping with clinical findings and formulate an appropriate diagnosis.

[1]  J. Fritschy,et al.  Is my antibody‐staining specific? How to deal with pitfalls of immunohistochemistry , 2008, The European journal of neuroscience.

[2]  A. Renshaw.  Henry??s Clinical Diagnosis and Management by Laboratory Methods , 2007 .

[3]  H. Zola,et al.  Leukocyte and Stromal Cell Molecules: The CD Markers , 2007 .

[4]  Karel Drbal,et al.  CD molecules 2005: human cell differentiation molecules. , 2005, Blood.

[5]  C. Massone,et al.  Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients. , 2005, Blood.

[6]  H. Kerl,et al.  EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. , 1997, Blood.

[7]  R. Espinosa,et al.  Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[8]  John Calvin Reed,et al.  Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. , 1993, Blood.

[9]  P. Schein,et al.  Cutaneous T‐cell lymphoma , 1976, Cancer.

[10]  R. Mcpherson,et al.  Overview of the Immune System and Immunologic Disorders , 2011 .

[11]  G. Strutton.  41 – Cutaneous infiltrates – lymphomatous and leukemic , 2010 .

[12]  R. Christopherson,et al.  The applicability of a cluster of differentiation monoclonal antibody microarray to the diagnosis of human disease. , 2008, Methods in molecular biology.

[13]  G. Burg,et al.  Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. , 2002, Journal of the American Academy of Dermatology.

[14]  N. Macintyre,et al.  Unmasking antigens for immunohistochemistry. , 2001, British journal of biomedical science.

[15]  O. Braun-falco,et al.  Differentiation Between Pseudolymphomas and Malignant B Cell Lymphomas of the Skin , 1982 .

[16]  好彦 滝口,et al.  Cutaneous T cell lymphoma associated with recurrent panniculitis and reactive histiocytosis. , 1981 .