Applying Regression Analysis to Study the Interdependence of Thyroid, Adrenal Glands, Liver, and Body Weight in Hypothyroidism and Hyperthyroidism

The complexity and diversity of the structure and activity of the body cause the involvement of mathematical apparatus for its study. For the first time, be means of the regression analysis, it was investigated the possibility of using the interdependence of weight of thyroid gland, adrenal glands, liver, and body weight indicators as clinical features of hypothyroidism and hyperthyroidism. The study was conducted on white rats under model conditions of alimentary hypothyroidism and thyreoidinum-induced hyperthyroidism. Such a clinical marker of hypothyroidism has been found out to be a simultaneous increase in thyroid weight and a decrease in adrenal weight, which occur against the background of weight gain. A decrease in thyroid weight along with an increase in adrenals and liver weights is a clinical marker of hyperthyroidism. The studies have confirmed the fundamental view of body weight as an informative indicator of the general state of the organism, as well as our earlier assumptions about the affiliation of the thyroid gland, adrenal glands, and liver to a single functional module.