Alterations in serum biochemical parameters of patients with lung cancer exposed to radiotherapy

In this study, the alterations in serum biochemical parameters of patients with lung cancer exposed to radiotherapy was investigated. For this aim, the levels of serum gamma glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), bilurubin (BLB), copper (Cu), sodium (Na) and potassium (K) were evaluated before and after radiotherapy. Serum enzyme, protein, Na and K levels were determined using an autoanalyzer. Serum Cu analysis was made with Atomic Absorbtion Spectrophotometre (AAS). Although we found significant increases in levels of GGT, BLB, Cu and K in patients, levels of AST, ALT, ALB and Na in patients showed significant decreases. The levels of serum AST and ALT fairly decreased after radiotherapy. The level of GGT in patients was significant higher than that in the controls before radiotherapy. However, GGT level showed again a distinctly decrease after radiotherapy. There was an inverse relationship among serum BLB, Cu and ALB values. Besides, serum Na levels showed significantly decrease in patients at the end of radiotherapy treatment compared to the controls and before radiotherapy, and K levels increased significantly following radiotherapy. In conclusion, the selected serum parameters are very sensitive and useful biomarkers for the study of the effects of radiotherapy.

[1]  K. Çavuşoğlu,et al.  Radioprotective effect of lycopene on chromosomal aberrations (CAs) induced by gamma radiation in human lymphocytes. , 2009, Journal of environmental biology.

[2]  K. Çavuşoğlu,et al.  Chromosomal aberrations induced by radiotherapy in lymphocytes from patients with lung cancer. , 2009, Journal of environmental biology.

[3]  S. Hussain,et al.  Prognostic and diagnostic value of serum pseudocholinesterase, serum aspartate transaminase, and serum alinine transaminase in malignancies treated by radiotherapy. , 2008, Journal of cancer research and therapeutics.

[4]  Saraswathy Cp,et al.  Monitoring of cellular enzymes in the serum of electroplating workers at Coimbatore. , 2007 .

[5]  M A El-Missiry,et al.  Ameliorative effect of melatonin against gamma-irradiation-induced oxidative stress and tissue injury. , 2007, Ecotoxicology and environmental safety.

[6]  N. Uren,et al.  EFFECTS OF ARTIFICIAL ULTRAVIOLET C RADIATION ON SEVERAL BLOOD AND URINE PARAMETERS RELATED TO RENAL AND HEPATIC FUNCTIONS IN ALBINO MICE , 2007 .

[7]  C. Saraswathy,et al.  Monitoring of cellular enzymes in the serum of electroplating workers at Coimbatore. , 2007, Journal of environmental biology.

[8]  P. Boyle,et al.  Preventing the lung cancer epidemic. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

[9]  M. Gaber Effect of γ-irradiation on the molecular properties of bovine serum albumin , 2005 .

[10]  A. Ebadi,et al.  Effects of 50 HZ Magnetic Field on Some Factors of Immune System in the Male Guinea Pigs , 2005 .

[11]  M. Gaber Effect of gamma-irradiation on the molecular properties of bovine serum albumin. , 2005, Journal of bioscience and bioengineering.

[12]  I. Garba,et al.  Serum Alkaline Phosphatase Activity As A Potential Biomarker For The Intergrity Of The Hepatic Drainage System In Acute Falciparum Malaria Infection , 2004 .

[13]  N. Ekinci,et al.  An alternative method for the determination of element concentrations in schizophrenic, lung cancer and leukaemia patient bloods , 2004 .

[14]  K. Manda,et al.  Pre-administration of beta-carotene protects tissue glutathione and lipid peroxidation status following exposure to gamma radiation. , 2003, Journal of environmental biology.

[15]  W. Morgan,et al.  Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect. , 2003, Cancer research.

[16]  A. Natarajan,et al.  Chromosome aberrations: past, present and future. , 2002, Mutation research.

[17]  E. Shacter QUANTIFICATION AND SIGNIFICANCE OF PROTEIN OXIDATION IN BIOLOGICAL SAMPLES* , 2000, Drug metabolism reviews.

[18]  D. Piskorska,et al.  Effect of Electromagnetic Field on Serum Biochemical Parameters in Steelworkers , 1999 .

[19]  G. Minuk,et al.  Canadian Association of Gastroenterology Practice Guidelines: evaluation of abnormal liver enzyme tests. , 1998, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[20]  H. Apell,et al.  Effects of Free Radicals on Partial Reactions of the Na,K-ATPase , 1997, The Journal of Membrane Biology.

[21]  P. Rosenthal,et al.  Assessing liver function and hyperbilirubinemia in the newborn. National Academy of Clinical Biochemistry. , 1997, Clinical chemistry.

[22]  C. Brugnara,et al.  Effect of irradiation on red cell cation content and transport , 1992, Transfusion.

[23]  C. Waternaux,et al.  Low-level lead exposure and children's cognitive function in the preschool years. , 1991, Pediatrics.

[24]  R. Wennberg,et al.  Experimental Bilirubin Encephalopathy: Importance of Total Bilirubin, Protein Binding, and Blood-Brain Barrier , 1986, Pediatric Research.

[25]  E. Fiala,et al.  INCREASED γ-GLUTAMYL TRANSFERASE ACTIVITY IN HUMAN COLON CANCER , 1979, The Lancet.

[26]  E. Fiala,et al.  Increased gamma-glutamyl transferase activity in human colon cancer. , 1979, Lancet.

[27]  A. O. Pedersen,et al.  Photooxidation of human serum albumin and its complex with bilirubin. , 1977, European journal of biochemistry.