Fate of Dysfunctional Bladder after Pediatric Renal Transplantation

Introduction: Graft function on long term into patients with LUTD is still a myth, So, we aimed know the natural history of LUTD and graft function into patient with abnormal lower urinary tract. Patient and methods: The study was conducted by retrospective review of 129 files of pediatric live renal transplant patients; Patients in either group had clinical evaluation of lower urinary tract function and assessment of graft functions at least one year after RT. Results: On evaluation the magnitude of change of cystometric variables we found 57% improvement of incidence of urodynamic detrusor overactivity and 48% improvement in patient categorized as poor/decreased compliance. There was 90% increase in the number of patients with adequate capacity. Patients showed 55.5% decrease in the number of patient with high PVR. Conclusion: Live donor renal transplant into pediatric patients with LUTD due to organic or neurogenic lower urinary tract pathology showed high serum creatinine on long term follow up.

[1]  A. Hussein,et al.  Outcome of pediatric renal transplantation in urological versus non-urological causes of end stage renal disease: Does it matter? , 2017, Journal of pediatric urology.

[2]  S. Schneeberger,et al.  Trial design and endpoints in clinical transplant research , 2016, Transplant international : official journal of the European Society for Organ Transplantation.

[3]  M. ElSheemy,et al.  Outcomes of living donor renal transplantation in children with lower urinary tract dysfunction: a comparative retrospective study , 2016, BJU international.

[4]  R. Correa,et al.  Kidney transplant in pediatric patients with severe bladder pathology , 2015, Pediatric transplantation.

[5]  A. Duzova,et al.  Does lower urinary tract status affect renal transplantation outcomes in children? , 2015, Transplantation proceedings.

[6]  S. Marks,et al.  Long-term outcomes of children after solid organ transplantation , 2014, Clinics.

[7]  S. Song,et al.  Bladder capacity in kidney transplant patients with end-stage renal disease , 2014, International Urology and Nephrology.

[8]  A. Retik,et al.  Risk factors for urinary tract infection after renal transplantation and its impact on graft function in children and young adults. , 2010, The Journal of urology.

[9]  K. Nonomura,et al.  Pediatric kidney transplantation is safe and available for patients with urological anomalies as well as those with primary renal diseases , 2009, Pediatric transplantation.

[10]  M. Bakkaloğlu,et al.  Renal transplantation in children with lower urinary tract dysfunction of different origin: a single-center experience. , 2008, Transplantation proceedings.

[11]  T. van Achterberg,et al.  Lower urinary tract symptoms after renal transplantation in children. , 2006, Journal of Urology.

[12]  I. Zamora,et al.  Renal transplantation in children with severe bladder dysfunction. , 2005, The Journal of urology.

[13]  M. Ghoneim,et al.  Renal transplantation in children with abnormal lower urinary tract. , 2004, Transplantation proceedings.

[14]  O. Mehls,et al.  Pediatric renal transplantation and the dysfunctional bladder , 2004, Transplant international : official journal of the European Society for Organ Transplantation.

[15]  A. Jevnikar,et al.  Long-term results of pediatric renal transplantation into a dysfunctional lower urinary tract , 2003, Transplantation.

[16]  S. Massry,et al.  Therapy of Renal Diseases and Related Disorders , 1984, Springer US.