FIELD-PROGRAMMABLE MICROFLUIDIC TEST PLATFORM FOR POINT-OF-CARE DIAGNOSTICS

[1]  S. Garimella,et al.  Electrical actuation of electrically conducting and insulating droplets using ac and dc voltages , 2008 .

[2]  Jun Zeng,et al.  Principles of droplet electrohydrodynamics for lab-on-a-chip. , 2004, Lab on a chip.

[3]  Viktor Stein,et al.  Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets. , 2009, Analytical chemistry.

[4]  S. Fan,et al.  Digital microfluidic operations on micro-electrode array architecture , 2011, NEMS 2011.

[5]  A. P. Casimiro,et al.  CMOS compatible HV gate-shifted LDD-NMOS , 2001 .

[6]  Zhishan Hua,et al.  Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens. , 2010, Diagnostic microbiology and infectious disease.

[7]  J. Homola Surface plasmon resonance sensors for detection of chemical and biological species. , 2008, Chemical reviews.

[8]  A. Manz,et al.  Lab-on-a-chip: microfluidics in drug discovery , 2006, Nature Reviews Drug Discovery.

[9]  T. Higuchi,et al.  Chemical reactions in microdroplets by electrostatic manipulation of droplets in liquid media. , 2002, Lab on a chip.

[10]  Hang Lu,et al.  Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans , 2009, Current Opinion in Neurobiology.

[11]  H. Verheijen,et al.  REVERSIBLE ELECTROWETTING AND TRAPPING OF CHARGE : MODEL AND EXPERIMENTS , 1999, cond-mat/9908328.

[12]  K. Audus,et al.  Digital microfluidics. , 2012, Annual review of analytical chemistry.

[13]  Roland Zengerle,et al.  Microfluidic platforms for lab-on-a-chip applications. , 2007, Lab on a chip.

[14]  S. Fan,et al.  Cross-scale electric manipulations of cells and droplets by frequency-modulated dielectrophoresis and electrowetting. , 2008, Lab on a chip.

[15]  L. Benini,et al.  CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement , 2006, IEEE Journal of Solid-State Circuits.

[16]  Saibal Mukhopadhyay,et al.  Leakage current mechanisms and leakage reduction techniques in deep-submicrometer CMOS circuits , 2003, Proc. IEEE.

[17]  R. Guerrieri,et al.  Capacitive sensor array for localization of bioparticles in CMOS lab-on-a-chip , 2004, 2004 IEEE International Solid-State Circuits Conference (IEEE Cat. No.04CH37519).

[18]  Y. Mita,et al.  Test Structure for Characterizing Low Voltage Coplanar EWOD System , 2009, IEEE Transactions on Semiconductor Manufacturing.

[19]  John Ralston,et al.  Influence of the Electrical Double Layer in Electrowetting , 2003 .

[20]  Y. Fouillet,et al.  Dynamics of droplet transport induced by electrowetting actuation , 2008 .

[21]  R. Fair,et al.  Picoliter DNA sequencing chemistry on an electrowetting-based digital microfluidic platform. , 2011, Biotechnology journal.

[22]  Han J G E Gardeniers,et al.  A digital microfluidic system for the investigation of pre-steady-state enzyme kinetics using rapid quenching with MALDI-TOF mass spectrometry. , 2007, Analytical chemistry.

[23]  L. Jang,et al.  Effect of electrode geometry on performance of EWOD device driven by battery-based system , 2009, Biomedical microdevices.

[24]  Stephen M. Trimberger Field-Programmable Gate Array Technology , 2007 .

[25]  Joonwon Kim,et al.  Using EWOD (electrowetting-on-dielectric) actuation in a micro conveyor system , 2005 .

[26]  Booncharoen Wongkittisuksa,et al.  Label-free capacitive immunosensor for microcystin-LR using self-assembled thiourea monolayer incorporated with Ag nanoparticles on gold electrode. , 2008, Biosensors & bioelectronics.

[27]  Vijay Srinivasan,et al.  Development of a digital microfluidic platform for point of care testing. , 2008, Lab on a chip.

[28]  Teodor Veres,et al.  Integration and detection of biochemical assays in digital microfluidic LOC devices. , 2010, Lab on a chip.

[29]  Kamran Mohseni,et al.  Electrostatic force calculation for an EWOD-actuated droplet , 2007 .

[30]  A. Wheeler,et al.  Digital microfluidic method for protein extraction by precipitation. , 2009, Analytical chemistry.

[31]  Jack Zhou,et al.  Chemical and Biological Applications of Digital-Microfluidic Devices , 2007, IEEE Design & Test of Computers.

[32]  Petra Schwille,et al.  A New Embedded Process for Compartmentalized Cell‐Free Protein Expression and On‐line Detection in Microfluidic Devices , 2005, Chembiochem : a European journal of chemical biology.

[33]  S. Fan,et al.  General digital microfluidic platform manipulating dielectric and conductive droplets by dielectrophoresis and electrowetting. , 2009, Lab on a chip.

[34]  H. Dahms Electrocapillary Measurements at the Interface Insulator‐Electrolytic Solution , 1969 .

[35]  Daniel Teng,et al.  Three-dimensional digital microfluidics and applications , 2012, 2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS).

[36]  Sung Kwon Cho,et al.  Micro air bubble manipulation by electrowetting on dielectric (EWOD): transporting, splitting, merging and eliminating of bubbles. , 2007, Lab on a chip.

[37]  A. deMello,et al.  Droplet microfluidics: recent developments and future applications. , 2011, Chemical communications.

[38]  Lin Lu,et al.  Electrowetting-based multi-microfluidics array printing of high resolution tissue construct with embedded cells and growth factors , 2007 .

[39]  Hans Zappe,et al.  A MEMS-based variable micro-lens system , 2006 .

[40]  Andreas Manz,et al.  Latest developments in micro total analysis systems. , 2010, Analytical chemistry.

[41]  Sung Kwon Cho,et al.  Concentration and binary separation of micro particles for droplet-based digital microfluidics. , 2007, Lab on a chip.

[42]  Darwin R. Reyes,et al.  Micro total analysis systems. 2. Analytical standard operations and applications. , 2002, Analytical chemistry.

[43]  M. Yamada,et al.  Continuous particle separation in a microchannel having asymmetrically arranged multiple branches. , 2005, Lab on a chip.

[44]  Aaron R Wheeler,et al.  A world-to-chip interface for digital microfluidics. , 2009, Analytical chemistry.

[45]  David Z. Pan,et al.  A High-Performance Droplet Routing Algorithm for Digital Microfluidic Biochips , 2008, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems.

[46]  Chii-Wann Lin,et al.  Micro-viscometer based on electrowetting on dielectric , 2007 .

[47]  Andreas Manz,et al.  Scaling and the design of miniaturized chemical-analysis systems , 2006, Nature.

[48]  C. Kim,et al.  Enhancement of mixing by droplet-based microfluidics , 2002, Technical Digest. MEMS 2002 IEEE International Conference. Fifteenth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.02CH37266).

[49]  A. Wheeler,et al.  The Digital Revolution: A New Paradigm for Microfluidics , 2009 .

[50]  Y. Fouillet,et al.  Ionic liquid droplet as e-microreactor. , 2006, Analytical chemistry.

[51]  Elaine F Reed,et al.  Specific binding and magnetic concentration of CD8+ T-lymphocytes on electrowetting-on-dielectric platform. , 2010, Biomicrofluidics.

[52]  W. Verboom,et al.  Optical sensing systems for microfluidic devices: a review. , 2007, Analytica chimica acta.

[53]  V. Bahadur,et al.  An energy-based model for electrowetting-induced droplet actuation , 2006 .

[54]  F. Ricci,et al.  A review on novel developments and applications of immunosensors in food analysis. , 2007, Analytica chimica acta.

[55]  Joseph A Loo,et al.  Incubated protein reduction and digestion on an electrowetting-on-dielectric digital microfluidic chip for MALDI-MS. , 2010, Analytical chemistry.

[56]  S. Cho,et al.  Low voltage electrowetting-on-dielectric , 2002 .

[57]  O. Velev,et al.  On-chip manipulation of free droplets , 2003, Nature.

[58]  Krishnendu Chakrabarty,et al.  A Digital-Microfluidic Approach to Chip Cooling , 2008, IEEE Design & Test of Computers.

[59]  R. Fair,et al.  An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids. , 2004, Lab on a chip.

[60]  N. F. de Rooij,et al.  Microfluidics meets MEMS , 2003, Proc. IEEE.

[61]  T. Jones More about the electromechanics of electrowetting , 2009 .

[62]  O. Velev,et al.  Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors , 2004, Nature materials.

[63]  T. Jones,et al.  Frequency-dependent electromechanics of aqueous liquids: electrowetting and dielectrophoresis. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[64]  Luke P. Lee,et al.  Innovations in optical microfluidic technologies for point-of-care diagnostics. , 2008, Lab on a chip.

[65]  Stephen R. Quake,et al.  Microfluidic Digital PCR Enables Multigene Analysis of Individual Environmental Bacteria , 2006, Science.

[66]  Richard B. Fair,et al.  Digital microfluidics: is a true lab-on-a-chip possible? , 2007 .

[67]  A. Wheeler,et al.  A digital microfluidic approach to homogeneous enzyme assays. , 2008, Analytical chemistry.

[68]  T. Jones,et al.  Dielectrophoretic liquid actuation and nanodroplet formation , 2001 .

[69]  Da-Jeng Yao,et al.  DNA ligation of ultramicro volume using an EWOD microfluidic system with coplanar electrodes , 2008 .

[70]  Fei Su,et al.  Design Automation Challenges for Microfluidics-Based Biochips* , 2005 .

[71]  K. Mohseni,et al.  Calculation of DEP and EWOD Forces for Application in Digital Microfluidics , 2008 .

[72]  Á. Ríos,et al.  Miniaturization through lab-on-a-chip: utopia or reality for routine laboratories? A review. , 2012, Analytica chimica acta.

[73]  Andreas G. Boudouvis,et al.  Manifestation of the connection between dielectric breakdown strength and contact angle saturation in electrowetting , 2005 .

[74]  K. H. Kang,et al.  An electrohydrodynamic flow in ac electrowetting. , 2009, Biomicrofluidics.

[75]  J V Yakhmi,et al.  Time response and stability of porous silicon capacitive immunosensors. , 2007, Biosensors & bioelectronics.

[76]  Song Zhang,et al.  Integration of electrochemistry in micro-total analysis systems for biochemical assays: recent developments. , 2009, Talanta.

[77]  Fei Su,et al.  Digital Microfluidic Biochips - Synthesis, Testing, and Reconfiguration Techniques , 2006 .

[78]  Tsung-Wei Huang,et al.  A fast routability- and performance-driven droplet routing algorithm for digital microfluidic biochips , 2009, 2009 IEEE International Conference on Computer Design.

[79]  C. Kim,et al.  Electrowetting and electrowetting-on-dielectric for microscale liquid handling , 2002 .

[80]  Russell Tessier,et al.  FPGA Architecture: Survey and Challenges , 2008, Found. Trends Electron. Des. Autom..

[81]  Philippe Dubois,et al.  Actuation potentials and capillary forces in electrowetting based microsystems , 2007 .

[82]  C.A.T. Salama,et al.  Modeling and characterization of CMOS-compatible high-voltage device structures , 1987, IEEE Transactions on Electron Devices.

[83]  C. Kim,et al.  Characterization of electrowetting actuation on addressable single-side coplanar electrodes , 2006 .

[84]  R. Fair,et al.  Electrowetting-based actuation of liquid droplets for microfluidic applications , 2000 .

[85]  H. Morgan,et al.  Programmable large area digital microfluidic array with integrated droplet sensing for bioassays. , 2012, Lab on a chip.

[86]  R. Zengerle,et al.  Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. , 2010, Chemical Society reviews.

[87]  Fei Su,et al.  Microfluidics-Based Biochips: Technology Issues, Implementation Platforms, and Design-Automation Challenges , 2006, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems.

[88]  Wyatt C. Nelson,et al.  Droplet Actuation by Electrowetting-on-Dielectric (EWOD): A Review , 2012 .

[89]  Jia Zhou,et al.  EWOD using P(VDF-TrFE) , 2009, 2009 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems.

[90]  Michael T. Laub,et al.  Continuous Particle Separation Through Deterministic Lateral Displacement , 2004 .

[91]  A. Wheeler,et al.  Let's get digital: digitizing chemical biology with microfluidics. , 2010, Current opinion in chemical biology.

[92]  V. Srinivasan,et al.  Heterogeneous immunoassays using magnetic beads on a digital microfluidic platform. , 2008, Lab on a chip.

[93]  Chengcheng Liu,et al.  Microfluidic chip-based aptasensor for amplified electrochemical detection of human thrombin , 2010 .

[94]  T. Jones,et al.  Microfluidic actuation of insulating liquid droplets in a parallel-plate device , 2011 .

[95]  Zhongkai Chen,et al.  Droplet routing in high-level synthesis of configurable digital microfluidic biochips based on microelectrode dot array architecture , 2011 .

[96]  M. S. Lu,et al.  A CMOS capacitive dopamine sensor with Sub-nM detection resolution , 2009, 2009 IEEE Sensors.

[97]  Bruno Berge,et al.  Électrocapillarité et mouillage de films isolants par l'eau , 1993 .

[98]  S. Cho,et al.  Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits , 2003 .

[99]  X. D. Hoa,et al.  Towards integrated and sensitive surface plasmon resonance biosensors: a review of recent progress. , 2007, Biosensors & bioelectronics.

[100]  Jr-Lung Lin,et al.  Integrated polymerase chain reaction chips utilizing digital microfluidics , 2006, Biomedical microdevices.

[101]  Yves Fouillet,et al.  Modeling microdrop motion between covered and open regions of EWOD microsystems , 2006 .

[102]  Da-Jeng Yao,et al.  Core—Shell Droplets for Parallel DNA Ligation of an Ultra-Micro Volume Using an EWOD Microfluidic System , 2010 .

[103]  T. G. Mitchell,et al.  Multiplexed real-time polymerase chain reaction on a digital microfluidic platform. , 2010, Analytical chemistry.

[104]  Vincent Linder,et al.  Microfluidics at the crossroad with point-of-care diagnostics. , 2007, The Analyst.

[105]  C. Kim,et al.  An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS. , 2006, Lab on a chip.

[106]  Fei Su,et al.  Droplet Routing in the Synthesis of Digital Microfluidic Biochips , 2006, Proceedings of the Design Automation & Test in Europe Conference.

[107]  C.H. Mastrangelo,et al.  Enhanced electro-osmotic pumping with liquid bridge and field effect flow rectification , 2004, 17th IEEE International Conference on Micro Electro Mechanical Systems. Maastricht MEMS 2004 Technical Digest.

[108]  R. Fair,et al.  A droplet-based lab-on-a-chip for colorimetric detection of nitroaromatic explosives , 2005, 18th IEEE International Conference on Micro Electro Mechanical Systems, 2005. MEMS 2005..

[109]  Adam T. Melvin,et al.  Micro total analysis systems: fundamental advances and applications in the laboratory, clinic, and field. , 2013, Analytical chemistry.

[110]  Bo Mattiasson,et al.  Continuous measurements of a binding reaction using a capacitive biosensor. , 2005, Biosensors & bioelectronics.

[111]  J. Stevenson,et al.  Room-Temperature Fabrication of Anodic Tantalum Pentoxide for Low-Voltage Electrowetting on Dielectric (EWOD) , 2008, Journal of Microelectromechanical Systems.

[112]  S. Cho,et al.  Towards digital microfluidic circuits: creating, transporting, cutting and merging liquid droplets by electrowetting-based actuation , 2002, Technical Digest. MEMS 2002 IEEE International Conference. Fifteenth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.02CH37266).

[113]  Booncharoen Wongkittisuksa,et al.  Capacitive biosensor for quantification of trace amounts of DNA. , 2009, Biosensors & bioelectronics.

[114]  Z. Xuefeng,et al.  Demonstration of Four Fundamental Operations of Liquid Droplets for Digital Microfluidic Systems Based on an Electrowetting-on-Dielectric Actuator , 2006 .

[115]  Eric P. Y. Chiou,et al.  EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis. , 2009, Lab on a chip.

[116]  R. Fair,et al.  Electrowetting-based actuation of droplets for integrated microfluidics. , 2002, Lab on a chip.

[117]  Michael George Pollack,et al.  ELECTROWETTING-BASED MICROACTUATION OF DROPLETS FOR DIGITAL MICROFLUIDICS , 2001 .

[118]  B. Hoefflinger,et al.  A parametric short-channel MOS transistor model for subthreshold and strong inversion current , 1984, IEEE Transactions on Electron Devices.

[119]  Mohamed Abdelgawad,et al.  All-terrain droplet actuation. , 2008, Lab on a chip.

[120]  S. Quake,et al.  Microfluidic Large-Scale Integration , 2002, Science.

[121]  M. Tabrizian,et al.  Biochip functionalization using electrowetting-on-dielectric digital microfluidics for surface plasmon resonance imaging detection of DNA hybridization. , 2009, Biosensors & bioelectronics.

[122]  A. deMello,et al.  Opportunities for microfluidic technologies in synthetic biology , 2009, Journal of The Royal Society Interface.

[123]  R. Fair,et al.  Low Voltage Electrowetting-on-Dielectric Platform using Multi-Layer Insulators. , 2010, Sensors and actuators. B, Chemical.

[124]  S. Hwang,et al.  Microchip‐based multiplex electro‐immunosensing system for the detection of cancer biomarkers , 2008, Electrophoresis.

[125]  P. Abshire,et al.  On-Chip Capacitance Sensing for Cell Monitoring Applications , 2007, IEEE Sensors Journal.

[126]  A. Wheeler,et al.  Digital microfluidics for cell-based assays. , 2008, Lab on a chip.

[127]  S. Sherman,et al.  Single-chip surface micromachined integrated gyroscope with 50°/h Allan deviation , 2002, IEEE J. Solid State Circuits.

[128]  Kristen L. Helton,et al.  Microfluidic Overview of Global Health Issues Microfluidic Diagnostic Technologies for Global Public Health , 2006 .

[129]  A. Manz,et al.  Miniaturized total chemical analysis systems: A novel concept for chemical sensing , 1990 .

[130]  Thomas B. Jones,et al.  On the Relationship of Dielectrophoresis and Electrowetting , 2002 .

[131]  R. Garrell,et al.  Electromechanical model for actuating liquids in a two-plate droplet microfluidic device. , 2009, Lab on a chip.

[132]  Samuel K Sia,et al.  Commercialization of microfluidic point-of-care diagnostic devices. , 2012, Lab on a chip.

[133]  H. B. Halsall,et al.  Microfluidic immunosensor systems. , 2005, Biosensors & bioelectronics.

[134]  C. Kim,et al.  Digital microfluidics with in-line sample purification for proteomics analyses with MALDI-MS. , 2005, Analytical chemistry.

[135]  Jean Berthier,et al.  Microdrops and digital microfluidics , 2008 .

[136]  R. Fair,et al.  A scaling model for electrowetting-on-dielectric microfluidic actuators , 2009 .

[137]  M.S.-C. Lu,et al.  CMOS Capacitive Sensors With Sub- $\mu$m Microelectrodes for Biosensing Applications , 2010, IEEE Sensors Journal.

[138]  M. Tabrizian,et al.  Nanostructured digital microfluidics for enhanced surface plasmon resonance imaging. , 2011, Biosensors & bioelectronics.

[139]  Monpichar Srisa-Art,et al.  Microdroplets: a sea of applications? , 2008, Lab on a chip.

[140]  Qi Zhang,et al.  Optical and electrochemical detection techniques for cell-based microfluidic systems , 2006, Analytical and bioanalytical chemistry.

[141]  Y. Liu,et al.  CMOS-based Magnetic Cell Manipulation System , 2007 .

[142]  C. Kim,et al.  Frequency-Based Relationship of Electrowetting and Dielectrophoretic Liquid Microactuation , 2003 .

[143]  A. Theberge,et al.  Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. , 2010, Angewandte Chemie.

[144]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[145]  R. Fair,et al.  Droplet-based microfluidic lab-on-a-chip for glucose detection , 2004 .

[146]  A. Wheeler,et al.  A digital microfluidic approach to proteomic sample processing. , 2009, Analytical Chemistry.

[147]  Thomas B. Jones,et al.  An electromechanical interpretation of electrowetting , 2005 .

[148]  Karl-Friedrich Böhringer Towards Optimal Strategies for Moving Droplets in Digital Microfluidic Systems , 2004, ICRA.

[149]  J. Baret,et al.  Electrowetting: from basics to applications , 2005 .